“…Our results show that the expression of NLRP1, ASC, and CASP-6 is present in a significantly greater number of hippocampal formation neurons in AD brains compared to controls, suggesting that the NLRP1 inflammasome is more active in the AD brain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The therapeutic effect of ursolic acid on OP may be achieved by regulating TP53, JUN, IL6, VEGFA, CASP3, and MAPK8 genes, respectively. It exhibits possible biological function in the treatment of OP mainly involve positive regulation of apoptotic process, response to drug, incytoplasm, cytosol, protein binding, identical protein binding. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…TP53, TP63, IL1B, IL18, IRF2, CASP5, CHMP4C, CHMP7, CASP1, and GSDME were detected with somatic mutations, among which, a majority displayed CNVs at high frequencies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Analysis of cell death markers indicated PANoptosis, comprised of apoptosis (increased CASP3, CASP8, BAD and reduced BCL2), necroptosis (increased RIPK1, RIPK3, and MLKL), and pyroptosis (increased GSDMD and ASC or PYCARD) in the DSP-deficient myocytes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This web server is based on the method tested in CASP9 (9th Critical Assessment of techniques for protein Structure Prediction) as ‘Seok-server’, which was assessed to be among top performing template-based modeling servers. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We benchmark RosettaLigand docking into comparative models for nine proteins built during CASP8 that contain ligands. We supplement the study with 21 additional protein/ligand complexes to cover a wider space of chemotypes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RNase J is a conserved ribonuclease that belongs to the β-CASP family of nucleases. It possesses both endo- and exo-ribonuclease activities, which play a key role in pre-rRNA maturation and mRNA decay. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, this server predicts tertiary structure of a sequence by feeding its predicted contacts and secondary structure to the CNS suite. Tested on the CASP and CAMEO targets, this server shows significant advantages over existing ones of similar category in both contact and tertiary structure prediction.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These polyphenols were docked to several targets, including APP, BACE, PSEN, IDE, CASP, calpain and TNF-α, suggesting potential in vivo activities. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We identify specific single nucleotide polymorphisms in CASP3 as candidate human resistance alleles that protect macrophages from S. aureus-derived dAdo, raising the possibility that the allelic repertoire of caspase-3 may contribute to the outcome of S. aureus infections in humans.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In murine abdominal sepsis by colon ascendens stent peritonitis (CASP), a strong increase in serum IgM and IgG antibodies was observed, which reached maximum values 14 days following sepsis induction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In terms of mechanism, the risk-score signature was positively associated with the expression of inflammatory molecules such as S100A11 and CASP4 in glioma. Overall, this study provided evidence for the activity of RNA Ψ modification in glioma malignancy and local immunity.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This report especially shows how the Critical Assessment of Protein Structure Prediction (CASP14) challenge was used to amplify student research efforts. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We use a confirmatory factor approach to investigate the internal of structure of the General Health Questionnaire (GHQ), Centre for Epidemiological Studies Depression scale (CES-D), Satisfaction with Life scale (SWLS) and CASP, a measure of quality of life in old age. In a second step, we examine the higher order structure of well-being using these measures. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Tissue was immunohistochemically stained for cell death markers of active caspase-3 (Casp-3) and TUNEL, and for the α7 and β2 nAChR subunits. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A total of 117 common targets between DEGs of IPF and drug targets were identified and included in the PPI network, in which AKT1, MAPK3, HSP90AA1, VEGFA, CASP3, JUN, HIF1A, CCND1, PTGS2, and MDM2 were predicted as key targets. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The expression levels of the factors involved in cell apoptosis (TNFα and its receptors, FAS, FASL, CASP3, CASP8, β-glycan, and DRAK2) were significantly higher in the granulosa cells of the atretic follicles compared to the healthy follicles. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Transfection with siRNA targeting NLRP3, cleaved caspase-1 (Casp-1) or ASC significantly reduced T. gondii-induced IL-1β production, whereas T. gondii proliferation was markedly increased. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also observed a concurrent physical dissociation between BIRC5 and ATG12–ATG5 (but not CASP3/caspase-3) and upregulation of autophagy in MDA-MB-231 and A549 cells under serum-deprived conditions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso