“…Moreover, LRV exacerbates disease in C57BL/6 mice but not in Casp11(−/−), Nlrp3(−/−), and 129 mice, a mouse strain that is naturally mutant for caspase-11. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Ns could increase the antioxidant activity in liver of mice and was able to regulate the apoptotic genes, Bcl2 and Casp3. We showed that NS has antioxidant, anti-apoptotic, and anti-inflammatory properties when it was used to treat the livers of mice infected with P. chabaudi.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…As described herein, this study used benchmark applications to evaluate the model constructions of human two-pore channel 2 (one target protein in CASP13 with its structure determined using cryo-EM data) and the overall structure of Enterococcus hirae V-ATPase complex.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, challenges of NDs induced less platelet pyroptosis and displayed less thrombocytopenia in P-selectin (Selp(-/-) ), Nlrp3 (Nlrp3(-/-) ) and caspase-1 (Casp1(-/-) ) mutants, as compared to the wild type mice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on the results of a stepwise Cox regression analysis, we built a four-gene predictive model including NLRP3, CASP3, IL18, and GSDMB. The model showed excellent predictive performance in internal and external validation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Computational methods for protein structure prediction have made significant strides forward, as evidenced by the last development of the neural network AlphaFold, which outperformed the CASP14 competitors by consistently predicting the structure of target proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our analyses replicate previously known associations in the melanocortin 1 receptor (MC1R) and tyrosinase (TYR) loci, while identifying novel potentially causal variants at the MTAP/CDKN2A and CASP8 loci. These results improve our understanding of the architecture of melanoma risk and outcome.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We showed that inhibition of circ-CREBBP can reduce the expression of MCL1, CREB1 and CREBBP and increase the expression of BAX and CASP3, thus promoting sperm apoptosis. Our results suggest that circ-CREBBP may be a promising biomarker and therapeutic target for male reproductive diseases.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, deletion of the Casp4 gene, which encodes caspase-11, impaired the activation of S1P and SREBP1 as well as altered the expression of genes regulated by SREBP1 in macrophages. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: This study revealed that the recurrent deletion of MAP3K7/CASP8AP2 is associated with SIL-TAL1 fusions and a mature immunophenotype, but not with response to treatment and risk of relapse. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among them, 6 genes including BCL2, BCL2L11, BAD, CASP7, CASP9, and CYCS expression reduced in tumor tissue compared to normal according to meta-analysis studies and RNA-seq TCGA data. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The TRPM2 and TRPV4-induced the excessive generations of ROS result in the increase of apoptosis and cell death via the activations of caspase -3 (Casp-3) and caspase -9 (Casp-9) in the neuronal cells, although their oxidant actions decrease the glutathione (GSH) and glutathione peroxidase (GSHPx) levels. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…YY1, hsa-mir-429, and hsa-mir-34a-5p play an important role in the expression of CASP1. Monocytes are high-caspase-1-expressing sentinel cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Upon Y(2)O(3)-NPs treatment, a significant increase in the early and late phases of apoptosis was revealed in MDA-MB-231 cells. qPCR results showed that Y(2)O(3)-NPs significantly upregulated the pro-apoptotic genes CASP3 and CASP8 as well as ferroptosis-related gene heme oxygenase-1 (HO-1), whereas the anti-apoptotic gene BCL2 was significantly downregulated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mice bearing M/D-driven tumors were allocated to RT, P or their combination in the optional presence of the CASP8 dimerizer AP20187, and monitored for tumor growth, progression-free survival and overall survival. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To investigate the activation of the inflammasome, we confirmed the mRNA and protein expression levels of the NLR family pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 (CASP-1). Moreover, we confirmed that caspase mediates the mature form of interleukin-18, and the cleaved form of Gasdermin D (GSDMD) was increased. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study, we analyzed the shared processes of pyroptosis in Ulcerative colitis (UC) and Crohn's disease (CD), as well as explored the correlation between the burden of pyroptosis and the results of anti-TNF treatment based on bioinformatics analyses. We identified CAPS1, CASP5, GSDMD, AIM2, and NLRP3 as the hub genes, with AIM2 being the most effective indicator for predicting the response to anti-TNF therapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We employed the MMAT guidelines for mixed, qualitative, and quantitative studies, and the PRISMA, CASP, and JBI guidelines to value the reviews. Results: A total of 55 studies met the inclusion criteria. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines and using CASP and PEDro tools for methodological quality assessment, we selected studies that included hip strengthening exercises as part of LBP treatment and measured pain and/or disability parameters. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This article systematically reviews the application of virtual technology for the prosthetic rehabilitation of upper limb amputees. (2) Methods: We followed PRISMA review guidance, STROBE, and CASP to evaluate the included articles. Finally, 17 articles were screened from 22,609 articles. (3) Results: This study reviews the possible benefits of using virtual technology from four aspects: usability, flexibility, psychological affinity, and long-term affordability. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso