“…Depending on the used lutein, H(2)O(2), or co-treatment of ARPE-19 cells, statistically significant differences in the expression of TXNIP, CXCL8, BAX, and CASP1 genes were confirmed by the RT-qPCR (p < 0.05). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The methodological quality was assessed through the Critical Appraisal Skills Programme (CASP) assessing only the studies performed on humans. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Meanwhile, apoptosis-related proteins MAP2K1, TUBA1C, RELA, and CASP6 were up-regulated. And the differentially expressed proteins were involved in regulating metabolic pathways. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…IPA analysis also showed top molecules up-regulated were BBC3, BIRC3, BIRC8, BNIP1, CASP7, CASP9, CD5, CDKN1A, CEBPG and COL4A3, top molecules down-regulated were ZNF443, UTP11L, TP73, TNFSF10, TNFRSF1B, TNFRSF25, TIAF1, STK17A, SST and SPP1, upstream regulator were NR3C1, TP53, dexamethasone , TNF and Akt. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Qualities of non-experimental and experimental research articles were assessed through the Critical Appraisal Skills Programme (CASP) checklist and Cochrane risk of bias criteria for Effective Practice and Organization of Care reviewsrespectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Study quality was assessed using the Critical Appraisal Skills Program (CASP) checklist specifically for randomized controlled trials. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The selected imaging studies were analyzed using a modified version of the critical Appraisal Skills Programme (CASP). Eleven studies encompassing 321 patients were selected. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Hub genes were validated in an external dataset, GSE30528, and cell models. RESULTS: MMP2, CASP3, and HIF-1α were identified as biomarkers, which were upregulated in the DN group and positively correlated with the infiltration of macrophages and M1 macrophages. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The performance of the method was also evaluated on proteins used in the ‘6th community-wide experiment on the critical assessment of techniques for protein structure prediction (CASP6)’. Based on the algorithm described, a web server, BhairPred (), has been developed, which can be used to predict β-hairpins in a protein using the SVM approach.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Hypermethylated promoter regions in normal breast epithelium, benign, and premalignant lesions within the same tumor biopsy implicate RASSF1, APC, GSTP1, TIMP3, CDKN2B, CDKN2A, ESR1, CDH13, RARB, CASP8, and TP73 as early events. DNA hypermethylation underlies the pathogenesis of step-wise transformation along a monoclonal continuum from normal to preneoplasia to invasive breast cancer.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Considering the results, the HADH2 gene on chromosome X, APBA1 gene on chromosome 9, AGER gene on chromosome 6, GSK3B gene on chromosome 3, CDKHR1 gene on chromosome 17, APPBP1 gene on chromosome 16, APBA2 gene on chromosome 15, GAL gene on chromosome 11, and APLP2 gene on chromosome 11 have the highest physiogenomics score (9.26) while the CASP3 gene on chromosome 4 and the SNCA gene on chromosome 4 have the lowest physiogenomics score (7.44). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Studies included in the final analysis underwent data extraction, critical appraisal using CASP and STROBE checklists, and thematic analysis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further distinguishing features of this ‘CIMP-Atypical’ subtype include an antiviral gene expression profile associated with pro-inflammatory M1 macrophages and CD8+ T cell infiltration, CASP8 mutations, and a well-differentiated state corresponding to normal SOX2 copy number and SOX2OT hypermethylation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…HC PBM and a corresponding decrease in SFM of two predicted mir-155-target mRNAs, apoptosis mediators CASP10 and APAF1. Using miR mimics, we demonstrate that mir-155 over-expression in healthy CD14+ cells conferred resistance to spontaneous apoptosis, but not Fas-induced death in these cells, and resulted in increased production of cytokines and chemokines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study, qRT-PCR, immunohistochemistry, immunofluorescence confocal microscopy were used to (1) assess the mRNA expression of NLRP3, IL-1β, CASP1 and ASC in paired biopsies from UC and CD patient, and (2) the colonic localization and spatial relationship of NLRP3 and IL-1β in active and quiescent disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The stronger cytotoxicity of GnRH-I and GnRH-III conjugates containing (4)Lys(Bu) was associated with a stronger inhibitory effect on the expression of growth-factor signaling elements in comparison with their (4)Ser counterparts, in which the upregulation of TP53 and caspases (e.g., CASP9) seemed to play a more important role. We were able to provide further evidence that targeting the GnRH receptor could serve as a successful therapeutic approach in colon cancer, and GnRH-III-[(4)Lys(Bu),(8)Lys(Dau=Aoa)] proved to be the best candidate for this purpose.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In cells treated with MG, liraglutide enhanced cell viability, reduced ROS levels and cell death (AnnexinV/PI); and trended to reduce anti-apoptotic signals (BAX, BCL2, CASP3). Pin1 silencing mimics neuronal metabolic impairment of patients with impaired glucose metabolism and neurodegeneration. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In network analysis, the hub targets of cinobufotalin injection against lung cancer were identified as VEGFA, EGFR, CCND1, CASP3, and AKT1. A network diagram of “drug-compounds-target-pathway” was constructed through network pharmacology to elucidate the pharmacological mechanism of the antilung cancer effect of cinobufotalin injection, which is conducive to guiding clinical medication.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Metabolic activity, cellular survival, caspase 3/7 activity (casp3/7), cell morphology, VEGF levels, and autophagy process were assessed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso