Mostrando 301 - 320 Resultados de 609 Para Buscar '"Chicos"', tiempo de consulta: 0.14s Limitar resultados
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    “…Two long-lived fly models with systemic IIS reductions (daGAL4/UAS-InR(DN) (ubiquitous expression of a dominant negative insulin receptor) and d2GAL/UAS-rpr (ablation of insulin-like peptide producing cells)) showed an amelioration of negative geotaxis senescence similar to that previously reported for the long-lived IIS mutant chico. In contrast, exploratory walking in daGAL4/UAS-InR(DN) and d2GAL/UAS-rpr flies declined with age similarly to controls. …”
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    “…These include ablating, or reducing the excitability of the insulin-producing cells (IPCs) that express dILPs-2,3,5 employing the dilp2,3,5(-/-) triple mutant, desensitizing insulin signaling using a chico mutation, or inhibiting dILP2 and 5 in the hemolymph by over-expressing Imaginal Morphogenesis Protein-Late 2 (Imp-L2). …”
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    “…However, a recent study in Drosophila has shown that Lnk is an important regulator of the insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway during growth, functioning in parallel to the insulin receptor substrate, Chico. As this pathway also has an evolutionary conserved role in the determination of organism lifespan, we investigated whether Lnk is required for normal lifespan in Drosophila. …”
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    “…Moreover, we find that the insulin receptor substrate chico is crucial to the survival of ZIKV-infected flies. …”
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