Airway Epithelial Inflammation In Vitro Augments the Rescue of Mutant CFTR by Current CFTR Modulator Therapies

por Gentzsch, Martina, Cholon, Deborah M., Quinney, Nancy L., Martino, Mary E. B., Minges, John T., Boyles, Susan E., Guhr Lee, Tara N., Esther, Charles R., Ribeiro, Carla M. P.
Publicado 2021

DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy

por He, Lihua, Kennedy, Andrew S., Houck, Scott, Aleksandrov, Andrei, Quinney, Nancy L., Cyr-Scully, Alexandra, Cholon, Deborah M., Gentzsch, Martina, Randell, Scott H., Ren, Hong Yu, Cyr, Douglas M.
Publicado 2021

A Novel Co-Culture Model Reveals Enhanced CFTR Rescue in Primary Cystic Fibrosis Airway Epithelial Cultures with Persistent Pseudomonas aeruginosa Infection

por Cholon, Deborah M., Greenwald, Matthew A., Higgs, Matthew G., Quinney, Nancy L., Boyles, Susan E., Meinig, Suzanne L., Minges, John T., Chaubal, Ashlesha, Tarran, Robert, Ribeiro, Carla M. P., Wolfgang, Matthew C., Gentzsch, Martina
Publicado 2023

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

por Armirotti, Andrea, Tomati, Valeria, Matthes, Elizabeth, Veit, Guido, Cholon, Deborah M., Phuan, Puay-Wah, Braccia, Clarissa, Guidone, Daniela, Gentzsch, Martina, Lukacs, Gergely L., Verkman, Alan S., Galietta, Luis J. V., Hanrahan, John W., Pedemonte, Nicoletta
Publicado 2019

A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase

por Ruan, Jingjing, Liang, Dongdong, Yan, Wenjing, Zhong, Yongwang, Talley, Daniel C., Rai, Ganesha, Tao, Dingyin, LeClair, Christopher A., Simeonov, Anton, Zhang, Yinghua, Chen, Feihu, Quinney, Nancy L., Boyles, Susan E., Cholon, Deborah M., Gentzsch, Martina, Henderson, Mark J., Xue, Fengtian, Fang, Shengyun
Publicado 2022

Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough

por Lee, Rhianna E., Lewis, Catherine A., He, Lihua, Bulik-Sullivan, Emily C., Gallant, Samuel C., Mascenik, Teresa M., Dang, Hong, Cholon, Deborah M., Gentzsch, Martina, Morton, Lisa C., Minges, John T., Theile, Jonathan W., Castle, Neil A., Knowles, Michael R., Kimple, Adam J., Randell, Scott H.
Publicado 2022