“…Cilia structure and function are regulated by ciliogenesis-associated kinase 1 (CILK1). Ciliopathies caused by CILK1 mutations show longer cilia and abnormal Hedgehog signaling. …”
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“…Herein, we investigated whether mice harboring either a heterozygous null Cilk1 (Cilk1(+/−)) mutation or a heterozygous loss-of-function Cilk1 mutation (Cilk1(R272Q/+)) have epilepsy. …”
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“…However, the effects of the JME-related mutations in CILK1 on kinase activity and CILK1 function are unknown. …”
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“…BROMI/TBC1D32 interacts with CCRK/CDK20, which phosphorylates and activates the intestinal cell kinase (ICK)/CILK1 kinase, to regulate the change in direction of the IFT machinery at the ciliary tip. …”
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“…The key software methods used are OpenMP, Intel Threading Building Blocks (TBB), Intel Cilk Plus, and the auto-vectorization capability of the Intel compiler (Composer XE). …”
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“…Furthermore, an inner ear-specific deletion of Cilk1 elicits low-frequency hearing loss attributable to cellular changes in apical cochlear identity that is dedicated to low-frequency sound detection. …”
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“…New and improved vectorization and auto-parallelization optimization features for Intel® Architecture-based processors, including the Intel® processor code-named Sandy Bridge and the Intel® AVX architecture, will be highlighted. Intel® Cilk Plus and a new array notation, technologies for implementing parallelism in applications, will be presented as well. …”
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“…This approach allows to abstract out the basic types such as scalar/vector but also to formalize generic computation kernels using transparently library or device specific constructs based on Vc, CUDA, Cilk+ or Intel intrinsics. While the main goal of this approach is portable performance, as a bonus, it comes with the insulation of the core application and algorithms from the technology layer. …”
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“…In various organisms, mutations in the orthologs of CCRK and those of the kinase ICK/CILK1, which is phosphorylated by CCRK, are known to result in cilia elongation. …”
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“…Furthermore, we demonstrate Isc10 can inhibit the autophosphorylation of the mammalian intestinal cell kinase ICK1 (also known as CILK1), suggesting a conserved mechanism of action. …”
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“…Furthermore, in IFT52-KO cells expressing an SRPS variant of IFT52, ciliary tip localization of ICK/CILK1 and KIF17, both of which are likely to be transported to the tip via binding to the IFT-B complex, was significantly impaired. …”
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“…In the present study, we identified the Sdccag8 C-terminal region (Sdccag8-C) as a module that interacts with the ciliopathy proteins, Ick/Cilk1 and Mak, which were shown to be essential for the regulation of ciliary protein trafficking and cilia length in mammals in our previous studies. …”
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“…Agenda 15:30 - Welcome (Frederic Hemmer) 15:35 - Rules and logistics (Alberto Di Meglio) 15:45 - Presentations (Session 1) 15:45 - Regressive network system testing (Adam Krajewski) 15:51 - The ViSION Health Monitor (Andrei Radu Patrascoiu) 15:57 - Improved metrics collection and visualization for the CERN cloud storage test framework (Carolina Lindqvist) 16:03 - Vectorization with Haswell and Cilk+ (Juan José Fumero Alfonso) 16:09 - Oracle AutoTask enhancement for multi-database environment (Tadeusz Dul) 16:15 - Evaluation of standard IT tools for industrial controls at CERN (Vlad Vintila) 16:21 - MatrixNet: Using a new multivariate technique in high energy physics (Viktoria Doneva) 16:27 - Electronic Ticket and Check-in System for Indico Conferences (Bernard Kolobara) Break 16:45 - Presentations (Session 2) 16:45 - Development of personal collections in CERN Document Server (CDS) (Archit Sharma) 16:51 - Integration of Cloud Storage Web Services with Invenio Digital Library (Kraljevic Zeliko) 16:57 - Advanced Visualisation Tools for CERN Institutional Data (Alberto Rodriguez Peon) 17:03 - CERN Storage Systems for Large-Scale Wireless Sensor Networks (Andrea Azzarà) 17:09 - Integration of network monitoring data in FTS3 (Rocio Rama Ballesteros) 17:15 - The Implementation of OpenStack Cinder and Integration with NetApp and Ceph (Gary Mcgilvary) 17:21 - Implementation and test of OpenStack Heat (Davide Michelino) 17:27 - Improvement of the IT-PES-PS Section Services Statistics Page (Alberto Montes Lopez) 17:33 - CERN Webfest and Citizen Science Challenges (Jiannan Zhang) 17:39 - Performance Improvements for the ATLAS Detector Simulation Framework (Yasin Almalioglu) 17:45 - Cocktail and online voting (evaluation panel separate meeting) 18:15 - Announcement of best presentation winners …”
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“…We identified seven new MALT1 substrates by the co-transfection screen: TANK, TAB3, CASP10, ZC3H12D, ZC3H12B, CILK1 and ILDR2. Using catalytically inactive cIAP2-MALT1 (Cys464Ala), a MALT1 inhibitor, MLT-748, and noncleavable P1-Arg to Ala mutant versions of each substrate in dual transfections, we validated the seven new substrates in vitro. …”
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