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83“…The Cinchona genus is important for humanity due to its ethnobotanical properties, and in particular its ability to prevent and treat malaria. …”
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84“…In this work, we report an unusually concise immobilization of Cinchona organocatalysts using thiol–ene chemistry, in which catalyst immobilization and bead polymerization is combined in a single step. …”
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86por Bosak, Anita, Ramić, Alma, Šmidlehner, Tamara, Hrenar, Tomica, Primožič, Ines, Kovarik, Zrinka“…This paper describes the synthesis and anticholinesterase potency of Cinchona-based alkaloids; ten quaternary derivatives of cinchonines and their corresponding pseudo-enantiomeric cinchonidines. …”
Publicado 2018
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87Quantitative determination of major alkaloids in Cinchona bark by Supercritical Fluid Chromatography“…Chinoline alkaloids found in Cinchona bark still play an important role in medicine, for example as anti-malarial and antiarrhythmic drugs. …”
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89“…An efficient approach to the synthesis of chiral selenoureas consisting of Cinchona alkaloid scaffolds was described. The new selenoureas were assessed as bifunctional organocatalysts in the asymmetric Michael addition reactions under mild conditions. …”
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90“…To efficiently address this challenge, we exploited the ability of catalysts based on a cinchona alkaloid scaffold to realize enantioselective organic transformations. …”
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91por Michele Lipucci Di Paola, M.L.P., Cristina Zuccato, C.Z., Lucia Carmela Cosenza, L.C.C., Matteo Zurlo, M.Z., Monica Borgatti, M.B., Ilaria Lampronti, I.L., Chris Sotirelis, C.T.S., Marco Prosdocimi, M.P., Roberto Gambari, R.G., Alessia Finotti, A.F.Enlace del recurso
Publicado 2023
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92por Warhurst, David C, Craig, John C, Adagu, Ipemida S, Meyer, David J, Lee, Sylvia Y“…BACKGROUND: The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo. …”
Publicado 2003
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94por Hansen, Steen Honoré, Holmfred, Else, Cornett, Claus, Maldonado, Carla, Rønsted, Nina“…The influence of the particle size of the obtained powders on the recovery of analytes in extracts of Cinchona bark was investigated using HPLC.…”
Publicado 2015
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95“…Michael addition reactions of triketopiperazine (TKP) derivatives to enones, mediated by a cinchona alkaloid-derived catalyst, deliver products in high yield and enantiomeric ratio (er). …”
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96por Katalinić, Maja, Zandona, Antonio, Ramić, Alma, Zorbaz, Tamara, Primožič, Ines, Kovarik, Zrinka“…Three Cinchona oximes (C1, C2, and C3), derivatives of the 9-oxocinchonidine, were synthesized and investigated in reactivation of various OP-inhibited AChE and BChE. …”
Publicado 2017
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97por Musikant, Daniel, Leverrier, Aurélie, Bernal, Diana, Ferri, Gabriel, Palermo, Jorge A., Edreira, Martin M.“…With this aim, a series of 16 hybrids of Cinchona alkaloids and bile acids were prepared by functionalization at position C-2 of the quinoline nucleus by a radical attack of a norcholane substituent via a Barton–Zard decarboxylation reaction. …”
Publicado 2019
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98por Nagy, Sándor, Fehér, Zsuzsanna, Dargó, Gergő, Barabás, Júlia, Garádi, Zsófia, Mátravölgyi, Béla, Kisszékelyi, Péter, Dargó, Gyula, Huszthy, Péter, Höltzl, Tibor, Balogh, György Tibor, Kupai, József“…Numerous cinchona organocatalysts with different substituents at their quinuclidine unit have been described and tested, but the effect of those saturation has not been examined before. …”
Publicado 2019
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99“…The substance class of the well-known Cinchona alkaloids is widened by 6′-Amino-cinchonine and 6′-Amino-cinchonidine, novel compounds which incorporate a primary amino function in the quinolinic ring system. …”
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100“…We evaluated selected cinchona alkaloids (cinchonidine and quinidine) for their potential of erythroid differentiation and augmentation of fetal hemoglobin production. …”
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