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401por Hendrickx, David, Varela Martínez, Carmen, Contzen, Matthias, Wagner-Wiening, Christiane, Janke, Karl-Heinz, Hernando Jiménez, Pablo, Massing, Susanne, Pichler, Jeanette, Tichaczek-Dischinger, Petra, Burckhardt, Florian, Stark, Klaus, Katz, Katharina, Jurke, Annette, Thole, Sebastian, Carbó, Rosa, del Pobil Ferré, Mariam Pascual, Nieto, Milagros, Zamora, María Jesús, Sisó, Ana, Pallares García, Pilar, Valdezate, Sylvia, Schaade, Lars, Worbs, Sylvia, Dorner, Brigitte Gertrud, Frank, Christina, Dorner, Martin Bernhard“…Of interest, and very unlike to other foodborne disease outbreaks which usually involves a single strain or virus variant, different Clostridium botulinum strains and toxin variants could be identified even from a single patient's sample. …”
Publicado 2023
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402por Edwards, Katie A., Randall, Eileen A., Wolfe, Patricia C., Angert, Esther R., Kraft, Clifford E.“…We found the thiaminase I enzyme from Clostridium botulinum efficiently degrades thiamine in the presence of pyridoxine (vitamin B6) as a co-substrate but has relatively limited activity in the presence of nicotinic acid (vitamin B3). …”
Publicado 2023
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403por Kim, Hyeon-Su, Kim, Si-Hyeon, Song, Hye-Soon, Kwon, Yong-Kuk, Park, Choi-Kyu, Kim, Hye-Ryoung“…PCR/RT-PCR assays revealed that broilers were negative for avian Clostridium botulinum, Newcastle disease virus, and avian encephalomyelitis virus. …”
Publicado 2023
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404“…The same is true for (32)P-ADP-ribosylation of Rho proteins which is catalysed by Clostridium botulinum exoenzyme C3. Also the amount of Rho-GDI and ERK2 as well as the level of overall (32)P-GTP binding acvitity was tumour-specific elevated, yet to a lower extent than Rho proteins. …”
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405“…BACKGROUND: Botulinum neurotoxin (BoNT), the causative agent of botulism, a serious neuroparylatic disease, is produced by the anaerobic bacterium Clostridium botulinum and consists of a family of seven serotypes (A-H). …”
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406por Terilli, Rebecca R, Moura, Hercules, Woolfitt, Adrian R, Rees, Jon, Schieltz, David M, Barr, John R“…BACKGROUND: Clostridium botulinum is the taxonomic designation for at least six diverse species that produce botulinum neurotoxins (BoNTs). …”
Publicado 2011
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407por Auer, Maria, Schweigreiter, Rüdiger, Hausott, Barbara, Thongrong, Sitthisak, Höltje, Markus, Just, Ingo, Bandtlow, Christine, Klimaschewski, Lars“…C3(bot) transferase, an exoenzyme produced by Clostridium botulinum, inactivates RhoA by ADP-ribosylation. …”
Publicado 2012
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408por Sriwai, Wimolpak, Mahavadi, Sunila, Al-Shboul, Othman, Grider, John R., Murthy, Karnam S.“…PAR2-AP-induced degradation of IkBa and activation of NF-kB were abolished by the blockade of RhoA activity by Clostridium botulinum C3 exoenzyme suggesting RhoA-dependent activation of NF-kB. …”
Publicado 2013
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409por Shirey, T. Brian, Dykes, Janet K., Lúquez, Carolina, Maslanka, Susan E., Raphael, Brian H.“…Lactobacillus spp. abundance was notably reduced in 12 of the 14 samples. Clostridium botulinum and Clostridium baratii were identified in low relative abundances in confirmed and non-confirmed samples based on their 16S rRNA gene profiles, although their toxigenicity remained undetermined. …”
Publicado 2015
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410por Williamson, Charles H. D., Sahl, Jason W., Smith, Theresa J., Xie, Gary, Foley, Brian T., Smith, Leonard A., Fernández, Rafael A., Lindström, Miia, Korkeala, Hannu, Keim, Paul, Foster, Jeffrey, Hill, Karen“…BACKGROUND: Clostridium botulinum is a diverse group of bacteria characterized by the production of botulinum neurotoxin. …”
Publicado 2016
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411por Fan, Yongfeng, Barash, Jason R., Lou, Jianlong, Conrad, Fraser, Marks, James D., Arnon, Stephen S.“…Background. Only Clostridium botulinum strain IBCA10-7060 produces the recently described novel botulinum neurotoxin type H (BoNT/H). …”
Publicado 2016
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412por Majowicz, Shannon E, Panagiotoglou, Dimitra, Taylor, Marsha, Gohari, Mahmood R, Kaplan, Gilaad G, Chaurasia, Ashok, Leatherdale, Scott T, Cook, Richard J, Patrick, David M, Ethelberg, Steen, Galanis, Eleni“…Exposure is defined as a provincially reported illness caused by Clostridium botulinum, Campylobacter, Cryptosporidium, Cyclospora, Giardia, hepatitis A virus, Listeria, non-typhoidal Salmonella spp, Salmonella Typhi, Salmonella Paratyphi, Shiga toxin-producing Escherichia coli, Shigella, Vibrio parahaemolyticus or Yersinia (excluding pestis). …”
Publicado 2020
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413por Mehta, Priyanka, Sahni, Shweta, Siddiqui, Samreen, Mishra, Neha, Sharma, Pooja, Sharma, Sachin, Tyagi, Akansha, Chattopadhyay, Partha, Vivekanand, A, Devi, Priti, Khan, Azka, Waghdhare, Swati, Budhiraja, Sandeep, Uppili, Bharathram, Maurya, Ranjeet, Nangia, Vivek, Shamim, Uzma, Hazarika, Pranjal P., Wadhwa, Saruchi, Tyagi, Nishu, Dewan, Arun, Tarai, Bansidhar, Das, Poonam, Faruq, Mohammed, Agrawal, Anurag, Jha, Sujeet, Pandey, Rajesh“…Among the co-pathogens present in our sample cohort, anaerobic bacteria accounted for a preponderance of bacterial diversity with possible role in respiratory distress. Clostridium botulinum, Bacillus cereus and Halomonas sp. are anaerobes found abundantly across the samples. …”
Publicado 2021
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414por Périer, Cindy, Martin, Vincent, Cornet, Sylvie, Favre‐Guilmard, Christine, Rocher, Marie‐Noelle, Bindler, Julien, Wagner, Stéphanie, Andriambeloson, Emile, Rudkin, Brian, Marty, Rudy, Vignaud, Alban, Beard, Matthew, Lezmi, Stephane, Kalinichev, Mikhail“…Clinically used botulinum neurotoxins (BoNTs) are natural products of Clostridium botulinum. A novel, recombinant BoNT type A1 (rBoNT/A1; IPN10260) has been synthesized using the native amino acid sequence expressed in Escherichia coli and has previously been characterized in vitro and ex vivo. …”
Publicado 2021
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415por Lorenc, Z Paul, Adelglass, Jeffrey M, Avelar, Rui L, Baumann, Leslie, Beer, Kenneth R, Cohen, Joel L, Cox, Sue Ellen, Dayan, Steven H, Dover, Jeffrey S, Downie, Jeanine B, Draelos, Zoe Diana, Goldman, Mitchel P, Gross, John E, Joseph, John H, Kaufman-Janette, Joely, Moy, Ronald L, Nestor, Mark, Schlessinger, Joel, Smith, Stacy R, Weiss, Robert A“…BACKGROUND: PrabotulinumtoxinA is a 900-kDa botulinum toxin type A produced by Clostridium botulinum. OBJECTIVES: The authors sought to investigate the safety of prabotulinumtoxinA for treatment of glabellar lines. …”
Publicado 2021
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416por Runtuwene, Lucky R., Sathirapongsasuti, Nuankanya, Srisawat, Raweewan, Komalamisra, Narumon, Tuda, Josef S. B., Mongan, Arthur E., Aboge, Gabriel O., Shabardina, Victoria, Makalowski, Wojciech, Nesti, Dela Ria, Artama, Wayan T., Nguyen-Thi, Lan Anh, Wan, Kiew-Lian, Na, Byoung-Kuk, Hall, William, Pain, Arnab, Eshita, Yuki, Maeda, Ryuichiro, Yamagishi, Junya, Suzuki, Yutaka“…Although the reads were also mapped to Clostridium botulinum, those were found to be artifacts derived from the cow genome. …”
Publicado 2022
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417“…BACKGROUND: Botulism, an often fatal neuroparalytic disease, is caused by botulinum neurotoxins (BoNT) which consist of a family of seven serotypes (A-H) produced by the anaerobic bacterium Clostridium botulinum. BoNT, considered the most potent biological toxin known, is a 150 kDa protein consisting of a 100 kDa heavy-chain (Hc) and a 50 kDa light-chain (Lc). …”
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418por Williamson, Charles H. D., Vazquez, Adam J., Hill, Karen, Smith, Theresa J., Nottingham, Roxanne, Stone, Nathan E., Sobek, Colin J., Cocking, Jill H., Fernández, Rafael A., Caballero, Patricia A., Leiser, Owen P., Keim, Paul, Sahl, Jason W.“…While multiple species of clostridia produce BoNTs, the majority of human botulism cases have been attributed to Clostridium botulinum groups I and II. Recent comparative genomic studies have demonstrated the genomic diversity within these BoNT-producing species. …”
Publicado 2017
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419por Sarita, R., Ponmariappan, Sarkaraisamy, Sharma, Arti, Kamboj, Dev Vrat, Jain, A. K.“…BACKGROUND & OBJECTIVES: Botulism, a potentially fatal paralytic illness, is caused by the botulinum neurotoxins (BoNTs) secreted by Clostridium botulinum. It is an obligate anaerobic, Gram-positive, spore-forming bacterium. …”
Publicado 2018
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420por Rosen, Hilary, Kimura, Akiko, Mukhopadhyay, Rituparna, Nash, June, Boetzer, Jason, Poe, Alyssa, Tecle, Selam, McAuley, Katherine, Kasirye, Olivia, Garza, Alvaro, Crandall, John, Shahkarami, Mahtab, Chaturvedi, Vishnu, Kiang, David, Vidanes, Jeff, McCoy, Kelly, Derby, Tammy, Barcellos, Mark, Jain, Seema, Vugia, D“…Patient specimens and suspect food items were tested for the presence of botulinum toxin and toxin-producing Clostridium botulinum; C. botulinum isolates underwent whole genome sequencing (WGS) at the CDPH laboratory. …”
Publicado 2018
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