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  1. 2181
    “…The CoMFA coefficient contour plots of the three models and comparisons among these plots provide clues regarding the main chemical features responsible for the biological activity variations and also result in predictions which correlate very well with the observed biological activity. …”
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    Comparative 3D QSAR study on β(1)-, β(2)-, and β(3)-adrenoceptor agonists
  2. 2182
    por Dumitriu, A, Popescu, BO
    Publicado 2010
    “…In contrast to other type of conditions, neurological disorders could provide specific clues in understanding the placebo effect, since the pathogenic mechanisms of different diseases might interfere with neuronal circuitry involved in the perception of disease symptoms. …”
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    Placebo Effects in Neurological Diseases
  3. 2183
    “…In the present article, we describe two patients with late detected coarctation to illustrate the clinical consequences, diagnostic clues for earlier detection and current therapeutic options to achieve optimal treatment. …”
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    Therapy refractory hypertension in adults: aortic coarctation has to be ruled out
  4. 2184
    “…Although light microscopic features of muscle are not pathognomonic in most cases of myasthenia gravis (MG), careful examination of neuromuscular junction by electron microscopy (EM) can reveal important clues for this disease. We report here a case of MG confirmed by EM study to emphasize that tissue diagnosis is still the best adjuvant to confirm the diagnosis. …”
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    A case of myasthenia gravis proven by ultrastructural study.
  5. 2185
    “…We assessed in vivo acute and sublethal toxicity by scoring for alteration of morphological traits, population growth rates, and influence on the regenerative capabilities providing new investigation clues for nanotoxicology purposes.…”
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    A New In Vivo Model System to Assess the Toxicity of Semiconductor Nanocrystals
  6. 2186
    por Tessera, Marc
    Publicado 2011
    “…However, such an approach must give clues to explain the emergence of distinct lineages to allow Darwinian natural selection. …”
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    Online Artículo Texto
    Origin of Evolution versus Origin of Life: A Shift of Paradigm
  7. 2187
    “…Dietary intervention studies provide clues to the likely risks of oncogenesis. High-protein diets lead to increases in N-nitroso compounds in fecal water and greater DNA damage as measured by the Comet assay, for example. …”
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    Recent Perspectives on the Relations between Fecal Mutagenicity, Genotoxicity, and Diet
  8. 2188
    “…By providing an overview of the mechanisms at play and the possible therapeutic avenues that have emerged, we hope to stimulate researchers to provide novel clues into the conundrum in SSc patients.…”
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    A System Out of Breath: How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis
  9. 2189
    por Yu, Qi, Li, Gong-Hua, Huang, Jing-Fei
    Publicado 2012
    “…Functional annotation showed that the immune-related and cancer-related proteins were always together and present in the same modules, which offer some clues for immune therapy for cancer. Our study around overlapping modules suggests a new perspective on the analysis of PPI network and improves our understanding of disease.…”
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    MOfinder: A Novel Algorithm for Detecting Overlapping Modules from Protein-Protein Interaction Network
  10. 2190
    “…These studies provide important clues as to the structural basis of immunological mimicry of carbohydrates.…”
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    Antibody Recognition of Cancer-Related Gangliosides and Their Mimics Investigated Using in silico Site Mapping
  11. 2191
    “…Furthermore we provide clues on the drugs mechanism of action.…”
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    Differential Trypanocidal Activity of Novel Macrolide Antibiotics; Correlation to Genetic Lineage
  12. 2192
    “…This technique may provide important clues into aetiological mechanism in patients with conditions predisposing to reflux into the airways.…”
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    Chronic Cough in Musculoskeletal disorders: Using high resolution oesophageal manometry in search of an Aetiology
  13. 2193
    por Machado-Vieira, Rodrigo
    Publicado 2012
    “…Many new tools and technologies have been developed but further efforts are required to provide clues on how these scientific advances in psychiatry may be translated into more effective therapeutic approaches. …”
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    Tracking the impact of translational research in psychiatry: state of the art and perspectives
  14. 2194
    “…Likewise, we detail chemical phosphoproteomic tools, including pros and cons with examples where these methods have been applied. In addition, basic clues of electrospray ionization and collision induced dissociation fragmentation are detailed in a simple manner for successful phosphoproteomic clinical studies.…”
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    Functional phosphoproteomic mass spectrometry-based approaches
  15. 2195
    “…CONCLUSIONS: This case suggests that multiple lipomas, insulinoma and gastrinoma may provide clues for a diagnosis of MEN1.…”
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    Multiple endocrine neoplasia type 1- presenting multiple lipomas and hypoglycemia onset
  16. 2196
    “…The fossil record leaves few clues that would allow us to recapitulate the path that evolution took to build a complex behavior, and the large population sizes and long time scales required prevent us from re-evolving such behaviors in a laboratory setting. …”
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    A Case Study of the De Novo Evolution of a Complex Odometric Behavior in Digital Organisms
  17. 2197
    “…Unveiling host factors and immune responses responsible for the elite status will likely provide clues for the design of therapeutic vaccines and functional cures. …”
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    Cell-Mediated Immunity in Elite Controllers Naturally Controlling HIV Viral Load
  18. 2198
    “…Understanding how psychosocial, genetic, immunological and neurotransmitter systems interact can reveal pathogenic clues and help target new preventive and symptomatic therapies.…”
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    Neuroinflammation and psychiatric illness
  19. 2199
    “…Network and pathway analyses gave us clues that NPM1, GATA2, and CEBPA were major driver genes. …”
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    Bioinformatics Interpretation of Exome Sequencing: Blood Cancer
  20. 2200
    “…In each case, a complete blood count provided clues for the diagnosis. A review of the literature is also included. …”
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    Unusual causes of papilledema: Two illustrative cases
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