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  1. 2441
    por Abelein, Axel, Johansson, Jan
    Publicado 2023
    “…The inhibition of Aβ oligomer generation in vitro seemingly correlates with the effects of treatment, giving indirect clues about the molecular mechanisms present in vivo. …”
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    Amyloid inhibition by molecular chaperones in vitro can be translated to Alzheimer's pathology in vivo
  2. 2442
    por Ranieri, Fiorenzo, Loscalzo, Yura
    Publicado 2023
    “…Besides illustrating the therapeutic process through clinical vignettes taken from the sessions, this paper also provides clues on how early social withdrawal can contribute to the construction of internal personality organizations that lead to social withdrawal up to self-reclusion (or Hikikomori).…”
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    Social Withdrawal in Preschool Age: A Clinical Case in Intensive Psychoanalytic Psychotherapy
  3. 2443
    “…Collectively, we not only revealed the phenomenon that the efflux pump is mainly responsible for tigecycline resistance, but also highlighted the mechanism at the genomic level, which will help in understanding the resistance mechanism in detail and provide clues for the treatment of clinical multiple drug-resistant A. baumannii.…”
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    The Mechanism of Tigecycline Resistance in Acinetobacter baumannii Revealed by Proteomic and Genomic Analysis
  4. 2444
    por Koo, Dae Lim
    Publicado 2023
    “…Recent studies have suggested that early recognition of specific sleep disturbances may provide clues for diagnosing autoimmune encephalitis. Furthermore, early diagnosis and treatment of sleep disturbances can promote recovery and improve long-term outcomes in patients with autoimmune encephalitis. …”
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    Sleep disturbances in autoimmune encephalitis
  5. 2445
    “…Their electronic, vibrational, and rotational dynamics provide valuable clues about the superfluid at the nanoscale. Here we report on the experimental study of the laser-induced rotation of helium dimers inside the superfluid (4)He bath at variable temperature. …”
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    Dynamics of molecular rotors in bulk superfluid helium
  6. 2446
    “…Snakes are an ancient reptile group, and their genomes can provide important clues for understanding the evolutionary history of reptiles. …”
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    The genome assembly and annotation of the many-banded krait, Bungarus multicinctus
  7. 2447
    “…Hence, we investigated the link between RA signaling and hindbrain segmentation in the sea lamprey Petromyzon marinus, an important jawless vertebrate model providing clues to decipher ancestral vertebrate features. …”
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    Sea lamprey enlightens the origin of the coupling of retinoic acid signaling to vertebrate hindbrain segmentation
  8. 2448
    por Gao, Yuan, Tian, Tian
    Publicado 2023
    “…Despite the limited findings between gut microbes and mTOR, elucidating their relationship may provide new clues for the prevention and treatment of various diseases.…”
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    mTOR Signaling Pathway and Gut Microbiota in Various Disorders: Mechanisms and Potential Drugs in Pharmacotherapy
  9. 2449
    “…Apoptosis induction and suppression of phospho-STAT3 levels were determined, the latter corroborated by docking of active curcuminoids into STAT3. Hence, promising new clues for the development of efficient and superior curcuminoids as valuable treatment options for one of the most lethal cancer diseases were discovered in this study.…”
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    Fluorinated and N-Acryloyl-Modified 3,5-Di[(E)-benzylidene]piperidin-4-one Curcuminoids for the Treatment of Pancreatic Carcinoma
  10. 2450
    “…Thus, the main goal of this review is to revisit the neuroprotective potential of some of the most predominant medicinal plants (and one fungus) used in traditional Chinese medicine (TCM), focusing on their proven mechanisms of action and their chemical compositions, to give clues on how they can be useful against neurodegeneration progression.…”
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    The neuroprotective effect of traditional Chinese medicinal plants—A critical review
  11. 2451
    “…The present findings also provide promising clues regarding how participants consider and process their visual world in healthy aging.…”
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    Link between fluid/crystallized intelligence and global/local visual abilities across adulthood
  12. 2452
    “…This review aimed to investigate the impact of various alterations in the tumor microenvironment on the antitumor and protumor effects of Th17 cells to provide valuable clues for the exploration of additional tumor immunotherapy strategies.…”
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    Factors impacting the benefits and pathogenicity of Th17 cells in the tumor microenvironment
  13. 2453
    “…Histologically, HSVN mimics other entities, though certain morphologic and immunohistochemical findings provide clues for diagnosis. However, HSVN still provides diagnostic challenges, especially on core biopsies with limited material for morphologic and molecular evaluation. …”
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    Hepatic small vessel neoplasm: not totally benign, not yet malignant
  14. 2454
    “…Recent studies gave some clues that PBUTs may also promote senescence in kidney tubular cells. …”
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    Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis
  15. 2455
    “…Thus, our results uncover an essential role of Nrdp1 in spermiogenesis and male fertility by promoting autophagy, providing important clues to cope with the related male reproductive diseases.…”
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    Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis
  16. 2456
    “…The above research results indicate that PmMYB6 is involved in the metabolic flux distribution of different branches of the phenylpropane metabolic pathway, and the results may provide clues for the regulation of metabolic fluxes between flavonoids and the lignin biosynthesis pathways of P. massoniana, as well as provide a basis for the molecular breeding of P. massoniana.…”
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    Cloning of PmMYB6 in Pinus massoniana and an Analysis of Its Function
  17. 2457
    “…The presented information provides important clues indicating directions for future research into the design of novel strategies for the effective control of infectious diseases caused by bacterial pathogens and parasitic nematodes.…”
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    Functional role of the TGF-β signaling in the Drosophila immune response
  18. 2458
    “…However, the spatial location of gene expression or of the cell in a complex tissue provides key clues to comprehend how the neighboring genes or cells cross talk, transduce signals and work together as a team to complete the job. …”
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    Spatial transcriptomics: Technologies, applications and experimental considerations
  19. 2459
    “…This review will provide a comprehensive understanding of tough conductive hydrogels and will offer clues to researchers who have interests in pursuing flexible sensors.…”
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    Advances in the Preparation of Tough Conductive Hydrogels for Flexible Sensors
  20. 2460
    por Lv, Mengfei, Zhang, Zhaolong, Cui, Yu
    Publicado 2023
    “…Insight of these processes can shed light on the regulation of T cell immunity on brain homeostasis and diseases and provide new clues for therapeutic approaches targeting brain injury and neurodegeneration.…”
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    Unconventional T cells in brain homeostasis, injury and neurodegeneration
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