“…SUMMARY: This paper focuses on the latest progress in the research of inherited RTA and systematically reviews the pathogenic genes, protein functions, clinical manifestations, internal relationship between genotypes and clinical phenotypes, diagnostic clues, differential diagnosis, and treatment strategies associated with inherited RTA. …”
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“…The biophysical properties of the mutated channel have been explored and analyzed through in vitro approaches, providing important clues to the general function/dysfunction of the wild-type and mutated channels. …”
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“…Their history of medication, self-medication, access to hypoglycaemic drugs, alcohol use and comorbidity may provide aetiological clues. The investigation involves obtaining blood samples during symptoms for laboratory glucose measurement or provoking fasting or postprandial hypoglycaemia as directed by symptoms. …”
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“…In this review, we describe the current IEI associated with atopy, using a comprehensive literature search and updates from the IUIS highlighting clinical clues for underlying IEI such as very early onset of atopic disease or treatment resistance to enable early and accurate genetic diagnosis. …”
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“…However, the main and still open challenge is to find clues for discovering clear linkages between aldehyde-induced modifications of specific proteins and the development of various diseases.…”
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“…Overall, our data suggest that in GBM, TIGIT acts as a regulator of a complex network, and provide new clues about its use as an immunotherapeutic target.…”
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“…This review discusses recent findings which provide clues to how neurons may control excitatory and inhibitory synapse formation, with focus on the involvement of the neuroligin family and PSD-95 in this process.…”
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“…Inspecting the significance of morphological discrepancies between the wild type and the mutants is expected to provide clues to uncover genes that are relevant to the biological processes producing a particular morphology. …”
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“…CONCLUSION: Differences between phenotypic and TUD analysis may provide clues to virus ancestry not previously inferred. …”
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“…The structures yield significant clues to the functionality of Lrp/AsnC-type regulators with respect to ligand binding and oligomerization states as well as to their role in specific and global DNA regulation.…”
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“…Mutations in the p53 tumor-suppressor gene are common in diverse types of cancer and could perhaps provide clues to the etiology of some cancers and to the effect of various environmental and occupational carcinogens in cancer development. …”
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“…In order that we may find some clues to develop an etiological hypothesis for each site of cancer, we obtained the correlation coefficient between the scores of the extracted factors and the variables on food and environmental agent, and performed stepwise regression methods as well. …”
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“…Since their discovery in the late 19th century, MBs have been thought to play a cellular morphogenetic role, but no cytological clues to the mechanism of MB biogenesis have been reported. …”
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“…The phenomenon of spontaneous regression and remission from cancer has been observed by many physicians and was described in hundreds of publications. However, suggestive clues on cause or trigger are sparse and not substantiated by much experimental evidence. …”
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“…These data are stored in online variation databases and provide important clues to the cause of diseases and potential side effects or resistance to drugs. …”
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“…Beyond their impact in the clinical setting (i.e. improving diagnosis and treatment), these markers are also likely to provide clues on the molecular mechanisms underlining the diseases. …”
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“…Many infectious and parasitic diseases, especially those newly emerging or reemerging, present a difficult diagnostic challenge because of their obscurity and low incidence. Important clues that could lead to an initial diagnosis are often overlooked, misinterpreted, not linked to a disease, or disregarded. …”
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“…While a causal link between agrichemicals and birth defects cannot be proven from this study an association might provide clues to common factors shared by both variables.…”
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“…This case may provide important clues for revising the definition of HFS, and allow the formation of effective preventive strategies for this side effect of chemotherapy.…”
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“…Through mining of the resulting compendium, we discovered that: (1) protein synthesis inhibitors can de-couple coordination of nuclear and mitochondrial transcription; (2) a subset of HMG-CoA reductase inhibitors, in combination with nonselective beta-adrenergic receptor antagonists, can cause mitochondrial toxicity, providing clues into statin-associated myopathy; and (3) structurally diverse microtubule inhibitors stimulate OXPHOS transcription while suppressing reactive oxygen species, via a PGC-1α/ERRα-dependent mechanism, and thus may have utility in treating age-associated degenerative disorders. …”
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