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  1. 3861
    “…Correct recognition of cyclin proteins could provide key clues for studying their functions. However, their sequences share low similarity, which results in poor prediction for sequence similarity-based methods. …”
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    Identification of cyclin protein using gradient boost decision tree algorithm
  2. 3862
    “…Totally, a prognostic model based on scRNA-seq and ITH was successfully constructed and validated in large cohorts, providing novel clues for ITH study of BCa.…”
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    Development and validation of an intra-tumor heterogeneity-related signature to predict prognosis of bladder cancer: a study based on single-cell RNA-seq
  3. 3863
    por Zhang, Datong, Gong, He, Meng, Fancui
    Publicado 2021
    “…An analysis of the protein–inhibitor interactions based on published co-crystal structures provides useful clues for the rational design of safe and effective small-molecule BTK inhibitors.…”
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    Recent Advances in BTK Inhibitors for the Treatment of Inflammatory and Autoimmune Diseases
  4. 3864
    “…At present, there are no available therapeutic remedies able to reduce Tau aggregation, nor are there any structural clues or guidelines for the rational identification of compounds preventing the accumulation of protein aggregates. …”
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    Chemoinformatics Analyses of Tau Ligands Reveal Key Molecular Requirements for the Identification of Potential Drug Candidates against Tauopathies
  5. 3865
    “…Therefore, this study highlights the unique features of Tscm different from those of other memory subsets and provides clues to understand the physiological and pathological functions of Tscm.…”
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    Characteristics of T-cell receptor repertoire of stem cell-like memory CD4+ T cells
  6. 3866
    “…The discovery of the previously overlooked COX-AIFM1(2) complex and clues provided by the structural model hint at potential roles of AIFM1 in oxidative phosphorylation biogenesis and in programmed cell death.…”
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    Molecular characterization of a complex of apoptosis-inducing factor 1 with cytochrome c oxidase of the mitochondrial respiratory chain
  7. 3867
    “…These results demonstrate the importance of temperature in determining the repeatability of evolutionary trajectories for the eukaryotic microbe Tetrahymena thermophila and may provide clues to how temperature affects evolution more generally.…”
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    Temperature affects the repeatability of evolution in the microbial eukaryote Tetrahymena thermophila
  8. 3868
    “…These results may provide potential clues for the intramolecular mechanisms of EGCG’s effect on A549 cells. …”
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    LC–MS Based Metabolomics Study of the Effects of EGCG on A549 Cells
  9. 3869
    “…These findings will provide valuable clues to guide therapeutic clinical applications.…”
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    Comparative Analysis of the Antioxidative and Hepatoprotective Activities of Dimethyl Diphenyl Bicarboxylate in Four Animal Models of Hepatic Injury
  10. 3870
    “…While commonly used tests in routine clinical practice provide clues to activation of different arms of immune response in patients with cirrhosis, specialized tests may help characterize this further. …”
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    Recognizing Dysfunctional Innate and Adaptive Immune Responses Contributing to Liver Damage in Patients With Cirrhosis
  11. 3871
    “…Based on this mathematical analysis, experimental clues are proposed for the control of capacitation levels. …”
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    Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation
  12. 3872
    “…Further research on these lncRNAs will provide new clues that could potentially improve the early diagnosis, prognostic prediction, and personalized treatments of patients with pancreatic cancer.…”
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    LncRNAs: Novel Biomarkers for Pancreatic Cancer
  13. 3873
    “…We review mechanisms of Ca(2+) membrane transporters and intracellular Ca(2+) sensors with evolutionary imprinting and structural clues. These may provide molecular and bioinformatics insights for the functional analysis of some non-model species in the evolutionarily important green plant lineages. …”
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    Molecular Evolution of Calcium Signaling and Transport in Plant Adaptation to Abiotic Stress
  14. 3874
    “…The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. …”
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    Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma
  15. 3875
    por LeDoux, Joseph E.
    Publicado 2022
    “…It also has practical implications, offering clues as to why efforts to treat problems related to fear and anxiety are not more effective, and what might make them better. …”
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    As soon as there was life, there was danger: the deep history of survival behaviours and the shallower history of consciousness
  16. 3876
    “…Furthermore, close evaluation of neonatal physiological parameters in the first 24 h of life might provide early clues concerning the severity of lung hypoplasia and the risk of adverse outcomes. …”
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    Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia
  17. 3877
    “…To gain a better understanding of the functions of the genes and proteins of the artificial bacteria, protein–protein interactions that may provide clues for the protein functions are included in an interactive manner. …”
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    Syn Wiki: Functional annotation of the first artificial organism Mycoplasma mycoides JCVI‐syn3A
  18. 3878
    por Melnyk, Stepan, Hakkak, Reza
    Publicado 2022
    “…Animal models can provide some clues about the etiology, development, prevention, and treatment of obesity. …”
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    Metabolic Status of Lean and Obese Zucker Rats Based on Untargeted and Targeted Metabolomics Analysis of Serum
  19. 3879
    “…The aim is to use more valuable clues for correct classes by reducing the impact of negative global features and extending the attention of salient local parts. …”
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    Synergy Factorized Bilinear Network with a Dual Suppression Strategy for Brain Tumor Classification in MRI
  20. 3880
    “…Initially, her symptoms served as clues to the diagnosis; however, the diagnosis was finally made and supported by joint aspiration. …”
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    The Development of Multiple Periprosthetic Joint Infections in Conjunction With Ibrutinib Therapy
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