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  1. 4061
    por Abrahamsen, Mitchell S.
    Publicado 2001
    “…In addition, the continued development and implementation of new software tools that can scan raw sequences for signs of genes and then identify clues as to potential functions, has provided the final realization of the potential rewards of genome sequencing. …”
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    Cryptosporidium Parvum Genome Project
  2. 4062
    “…Clinical features of gastroesophageal reflux disease-associated cough typical for adult patients and a specific questionnaire for evaluating gastroesophageal reflux disease validated in adults may also be useful diagnostic clues in adolescents.…”
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    Gastroesophageal reflux-associated chronic cough in an adolescent and the diagnostic implications: a case report
  3. 4063
    por Kim, Jaebum, He, Xin, Sinha, Saurabh
    Publicado 2009
    “…Finally, we report weak purifying selection on short deletions, providing important clues about overall spatial constraints on CRMs. …”
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    Evolution of Regulatory Sequences in 12 Drosophila Species
  4. 4064
    por Iwasaki, Wataru, Takagi, Toshihisa
    Publicado 2009
    “…The evolutionary history of biological pathways is of general interest, especially in this post-genomic era, because it may provide clues for understanding how complex systems encoded on genomes have been organized. …”
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    Rapid Pathway Evolution Facilitated by Horizontal Gene Transfers across Prokaryotic Lineages
  5. 4065
    “…The mechanisms of their association with CAD are unknown; relationships to other cardiovascular phenotypes may give mechanistic clues. Carotid artery intima-media thickness (CIMT) is a subclinical marker of atherosclerosis associated with stroke. …”
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    Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes
  6. 4066
    por Neuwald, Andrew F
    Publicado 2009
    “…How these families have evolutionarily diverged from each other at the sequence level provides clues to underlying mechanisms associated with their functional specialization. …”
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    The glycine brace: a component of Rab, Rho, and Ran GTPases associated with hinge regions of guanine- and phosphate-binding loops
  7. 4067
    “…We propose that the kinetics of the initial repair steps at MDS is a major parameter that direct towards the conversion of MDS into DSB. Data provides clues to the biological consequences of MDS in eukaryotic cells.…”
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    The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells
  8. 4068
    “…CONCLUSION: Our data provide novel insights into the architecture of gene expression in the allopolyploid nucleus, raise questions regarding the responsible underlying mechanisms of genome dominance, and provide clues into the enigma of the evolutionary prevalence of allopolyploids.…”
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    Genomic expression dominance in allopolyploids
  9. 4069
    “…We have explored the feasibility of obtaining clues to functions of such proteins by means of comparative analysis with cupins of known structure and function. …”
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    Structure-Based Phylogeny as a Diagnostic for Functional Characterization of Proteins with a Cupin Fold
  10. 4070
    “…The purpose of this study was to understand and to obtain clues to the possible function of the autocrine ERK activation during the calcium-induced differentiation of NHEK. …”
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    Autocrine Extracellular Signal-regulated Kinase Activation in Normal Human Keratinocytes is not Interrupted by Calcium Triggering and is Involved in the Control of Cell Cycle at the Early Stage of Calcium-induced Differentiation
  11. 4071
    “…OBJECTIVE: Regenerating organs in diverse biological systems have provided clues to processes that can be harnessed to repair damaged tissue. …”
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    Regeneration of the Pancreas in Adult Zebrafish
  12. 4072
    “…We also show that a mathematical measure based on the Fisher information matrix gives clues on the information quality of different data types to better represent the underlying metabolic network topology. …”
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    Metabolic network discovery through reverse engineering of metabolome data
  13. 4073
    “…This investigation provides new clues on both methodological and biological issues. …”
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    Using reads to annotate the genome: influence of length, background distribution, and sequence errors on prediction capacity
  14. 4074
    “…SIGNIFICANCE: These results provide important clues for soybean stress tolerance through manipulation of PHD-type transcription regulator.…”
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    Soybean GmPHD-Type Transcription Regulators Improve Stress Tolerance in Transgenic Arabidopsis Plants
  15. 4075
    “…CONCLUSION: Our result provides clues to the mechanistic aspects of miRNA strand selection in humans and other mammals. …”
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    Sequence features associated with microRNA strand selection in humans and flies
  16. 4076
    por Zamdborg, Leonid, Ma, Ping
    Publicado 2009
    “…By selecting TFBMs that are significantly associated with gene expression, we can identify active TFBMs under specific experimental conditions and thus provide clues for the construction of regulatory networks. …”
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    Discovery of protein–DNA interactions by penalized multivariate regression
  17. 4077
    “…General and systemic examinations provide valuable clues. Neurological examinations investigating sensory, motor and autonomic signs help to define the topography and nature of neuropathy. …”
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    Diagnostic approach to peripheral neuropathy
  18. 4078
    “…RESULTS: We analyzed the expression pattern of previously uncharacterized members of the astacin family to try and obtain clues to potential functions. Prominent sites of expression for many members of this family are the hypodermis, the alimentary system and several specialized cells including sensory sheath and sockets cells, which are located at openings in the body wall. …”
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    Characterization of the astacin family of metalloproteases in C. elegans
  19. 4079
    por Docherty, Sharon, Bagust, Jeff
    Publicado 2010
    “…CONCLUSIONS: The computerized rod and frame system may be improved by replacement of the line with two dots. This reduces clues provided to the subject by the appearance of the rod on the screen.…”
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    From line to dots: an improved computerised rod and frame system for testing subjective visual vertical and horizontal
  20. 4080
    “…These results demonstrate the complexity of the transcriptional profile of keratinocytes, providing important clues on which to base further investigations of the molecular events underlying keratinocyte differentiation.…”
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    Expression Profiling of Calcium Induced Genes in Cultured Human Keratinocytes
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