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  1. 4121
    por Sael, Lee, Kihara , Daisuke
    Publicado 2012
    “…BACKGROUND: Many of solved tertiary structures of unknown functions do not have global sequence and structural similarities to proteins of known function. Often functional clues of unknown proteins can be obtained by predicting small ligand molecules that bind to the proteins. …”
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    Constructing patch-based ligand-binding pocket database for predicting function of proteins
  2. 4122
    “…Heart auscultation provides clues to diagnose many cardiac abnormalities. Unfortunately, detection of relevant symptoms and diagnosis based on heart sound through a stethoscope is difficult. …”
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    Acoustic cardiac signals analysis: a Kalman filter–based approach
  3. 4123
    “…We deliberately chose a historical, comparative and cross-disciplinary approach, striving to reveal clues that may help predict the ultimate value of each animal model in spite of incomplete data.…”
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    Animal models of listeriosis: a comparative review of the current state of the art and lessons learned
  4. 4124
    “…PsRobot integrates the expression data of smRNAs in major plant smRNA biogenesis gene mutants and smRNA-associated protein complexes to give clues to the smRNA generation and functional processes. …”
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    PsRobot: a web-based plant small RNA meta-analysis toolbox
  5. 4125
    “…Unraveling intricacies of more complex proteomic interactions that involve additional microbes, i.e., PGPRs and symbiotic fungi, which strengthen plant defenses will generate valuable information on how pathosystems actually function in nature, and thereby provide clues to solving disease problems that engender major losses in crops every year.…”
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    Plants versus Fungi and Oomycetes: Pathogenesis, Defense and Counter-Defense in the Proteomics Era
  6. 4126
    “…Overall, our data provide biological clues in favor of a crucial and complementary embryonic role of the prion protein family in Eutherians and emphasizes the need to further evaluate its implication in normal and pathological human placenta biology.…”
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    Prion Protein and Shadoo Are Involved in Overlapping Embryonic Pathways and Trophoblastic Development
  7. 4127
    “…The monitorization of the acute response of the reactions has given clues for understanding these reactions and has promising results for the future of the immunological evaluation of HDR.…”
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    Immunologic Evaluation of Drug Allergy
  8. 4128
    “…This finding provides the clues for developing therapeutic strategies to promote sensory recovery and substitution.…”
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    The Functional Upregulation of Piriform Cortex Is Associated with Cross-Modal Plasticity in Loss of Whisker Tactile Inputs
  9. 4129
    “…Our findings may provide some clues to the pathophysiology of corneal keratocyte depletion in patients with Acanthamoeba keratitis.…”
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    Cytopathic effect of Acanthamoeba on human corneal fibroblasts
  10. 4130
    “…Since structure is typically associated with function, the structures of complex bird songs provide important clues to the evolution of animal communication systems. …”
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    Structural Design Principles of Complex Bird Songs: A Network-Based Approach
  11. 4131
    “…The ESTs reported here provide new clues to understand the disease-resistance mechanism in Chinese wild grapevine species and may enable us to investigate E. necator-responsive genes involved in PM resistance in grapevine germplasm.…”
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    Characterization of Erysiphe necator-Responsive Genes in Chinese Wild Vitis quinquangularis
  12. 4132
    “…Moreover, an algorithm, PrePPI, that combines structural information with other functional clues is comparable in accuracy to high-throughput experiments, yielding over 30,000 high confidence interactions for yeast and over 300,000 for human. …”
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    Structure-based prediction of protein-protein interactions on a genome-wide scale
  13. 4133
    “…Consideration of sub-phenotypes of wheezing may reveal important clues to aetiological risk factors. METHODS: Longitudinal phenotypes capturing population heterogeneity in wheezing reports from birth to 7 years were derived using latent class analysis in the Avon Longitudinal Study of Parents and Children (ALSPAC). …”
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    Associations of Different Phenotypes of Wheezing Illness in Early Childhood with Environmental Variables Implicated in the Aetiology of Asthma
  14. 4134
    por Asai, Tomohisa, Kanayama, Noriaki
    Publicado 2012
    “…Our results reflect that (1) our brain interprets successive stimuli on the skin as motion in terms of time and space (unimodal causality) and that (2) the concurrent signals from other modalities provide clues for creating unified representations of this external motion (multi-modal causality) as to the extent that “spatiotemporal” synchronicity among modalities is provided.…”
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    “Cutaneous Rabbit” Hops Toward a Light: Unimodal and Cross-Modal Causality on the Skin
  15. 4135
    “…To gain insights into the architecture of the protein and obtain clues about its function, we have tested their substrate specificity and solved the structure of VSP1. …”
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    The Crystal Structure of Arabidopsis VSP1 Reveals the Plant Class C-Like Phosphatase Structure of the DDDD Superfamily of Phosphohydrolases
  16. 4136
    “…Cues of female attractiveness are thus likely to reflect both fitness and reproductive potential, as well as compatibility with particular male phenotypes. In humans, absolute clues of fertility and indices of favorable developmental stability are generally associated with increased women’s attractiveness. …”
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    Men’s Preference for Women’s Facial Features: Testing Homogamy and the Paternity Uncertainty Hypothesis
  17. 4137
    “…There are neurophysiological clues that the various cutaneous senses may not share the same primary representation. …”
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    Subject-level differences in reported locations of cutaneous tactile and nociceptive stimuli
  18. 4138
    “…This study analyzed the survival of pulmonary MEC patients and attempted to find clues for optimal treatment. METHODS: A total of 21 patients with pulmonary MEC from November 2004 to January 2011 were included in the investigation. …”
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    Primary pulmonary mucoepidermoid carcinoma: an analysis of 21 cases
  19. 4139
    “…We tested the utility of a cross-species genetic interaction profiling approach to obtain clues to the molecular function of unannotated pathogenicity factors in the human pathogen Cryptococcus neoformans. …”
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    Approaching the Functional Annotation of Fungal Virulence Factors Using Cross-Species Genetic Interaction Profiling
  20. 4140
    por Marian, Valentin, Anolik, Jennifer H
    Publicado 2012
    “…Studies of murine genetic manipulations and human risk variants have provided important clues to the cellular and molecular pathogenesis of SLE, operating at multiple of these steps. …”
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    Treatment targets in systemic lupus erythematosus: biology and clinical perspective
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