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  1. 4201
    “…Our method can be generally used for protein expression and developmental studies at the embryonic level, but can also provide clues to understand the aging process and age-related diseases in particular.…”
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    An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging
  2. 4202
    “…Expression of 135 genes distinguishes PiZZ iPSC-hepatic cells, providing potential clues to liver disease pathogenesis. The disease-specific cells display intracellular accumulation of mutant AAT protein, resulting in increased autophagic flux. …”
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    Emergence of a Stage-Dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-Deficient iPS Cells
  3. 4203
    por Walker, Ruth H.
    Publicado 2015
    “…The age of onset, inheritance patterns, and ethnic background differ in each condition, providing diagnostic clues. Other investigations, including routine blood testing and neuroimaging can be informative. …”
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    Untangling the Thorns: Advances in the Neuroacanthocytosis Syndromes
  4. 4204
    por Cheng, Yiming, Perocchi, Fabiana
    Publicado 2015
    “…Candidate hits can be easily and flexibly prioritized by complementary clues on subcellular localization, known protein–protein interactions, membrane spanning regions and protein domains. …”
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    ProtPhylo: identification of protein–phenotype and protein–protein functional associations via phylogenetic profiling
  5. 4205
    “…The fundamental mechanism underlying this periodically protruding phenotype, involving folding and unfolding of the cortex‐membrane couple, is likely to hold important clues for diverse phenomena including cell division and amoeboid‐type migration. © 2015 The Authors. …”
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    Spatiotemporal relationships between the cell shape and the actomyosin cortex of periodically protruding cells
  6. 4206
    “…Obstacles include the lack of a unifying biological theory related to aging, inclusion of costly research measures, and its inability to provide specific clues to the etiology of frailty according to the frailty index definition. …”
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    Frailty: a tale of two concepts
  7. 4207
    “…The study thus provides essential mechanistic insight, and suggests clues for the effective management and treatment of CIT-related diseases.…”
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    Citreoviridin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis in Human Liver HepG2 Cells
  8. 4208
    “…Proteins associated with sperm maturation and fertilization were identified, including ATPase, clathrin, peroxiredoxins and enolase, which may provide clues to the molecular mechanisms enabling males to reproduce multiple times.…”
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    Proteomic Changes Associated with Successive Reproductive Periods in Male Polychaetous Neanthes arenaceodentata
  9. 4209
    “…However, the CBF data collected interictally has failed to show any distinguishing features or clues as to the underlying pathophysiology of the disease. …”
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    Primary Somatosensory Cortices Contain Altered Patterns of Regional Cerebral Blood Flow in the Interictal Phase of Migraine
  10. 4210
    por Dai, Yu-Lu, Huang, Su-Ling, Leng, Ying
    Publicado 2015
    “…Our results provided new and informative clues for better understanding of the role of AMPK in β-cell apoptosis.…”
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    AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms
  11. 4211
    “…Understanding the mechanism of the brain’s convoluted patterns can provide useful clues into normal and pathological brain function. …”
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    Cortical Folding Pattern and its Consistency Induced by Biological Growth
  12. 4212
    “…It also provided possible clues for the molecular mechanism of benzene-induced oxidative stress.…”
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    Overexpression of G6PD and HSP90 Beta in Mice with Benzene Exposure Revealed by Serum Peptidome Analysis
  13. 4213
    “…Studying this parasite’s reproductive strategies and population structure can also contribute key information to the understanding of the epidemiology of associated diseases; it can also provide clues for elaborating control programs and predicting the probability of success for control campaigns (such as vaccines and drug therapies), along with emergence or re-emergence risks. …”
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    Population Genetics and Reproductive Strategies of African Trypanosomes: Revisiting Available Published Data
  14. 4214
    “…These results provided a solid base for future functional genome study of the PHD-finger family in maize and afforded important clues for characterizing and cloning potentially important candidates in response to abiotic stresses.…”
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    Systematic Analysis of the Maize PHD-Finger Gene Family Reveals a Subfamily Involved in Abiotic Stress Response
  15. 4215
    “…Control of HIV replication is a rare immunological event, providing clues to understand the viral control mechanism. …”
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    Broadening of Virus-Specific CD8(+) T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers
  16. 4216
    “…Future studies on the role of miRNAs in OA will provide important clues leading to a better understanding of the mechanism(s) of OA and, more particularly, to the development of therapeutic targets for OA.…”
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    MicroRNAs' Involvement in Osteoarthritis and the Prospects for Treatments
  17. 4217
    “…CONCLUSION: The amino acid profile of peptones may provide clues to identify the most effective feeding strategies for recombinant CHO cells.…”
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    Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles
  18. 4218
    “…The cytological and biochemical findings of CSF can provide valuable clues in the diagnosis of bacterial meningitis.…”
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    Frequency of Streptococcus pneumoniae infection in patients with suspected meningitis in Imam Reza Hospital of Kermanshah in the west of Iran
  19. 4219
    “…Therefore, the present results concerning population structure will be important to further elucidate genetic features of wild rice, and will also give strong clues to utilize and conserve wild natural genetic resources.…”
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    Evaluation of genetic variation among wild rice populations in Cambodia
  20. 4220
    “…However, it is unclear which taxa and genes in the communities, and how they contribute to the bioremediation in the polluted soils. To get clues about this fundamental question here, time-course (up to 24 weeks) metagenomic analysis of microbial community in a closed soil microcosm artificially polluted with four aromatic compounds, including phenanthrene, was conducted to investigate the changes in the community structures and gene pools. …”
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    Time-series metagenomic analysis reveals robustness of soil microbiome against chemical disturbance
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