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  1. 4781
    “…Our results reveal the important role of Foxg1 in myelin development and provide new clues for further exploring the pathological mechanisms of FOXG1 syndrome.…”
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    Conditional Deletion of Foxg1 Delayed Myelination during Early Postnatal Brain Development
  2. 4782
    “…Our aim with this work is to help researchers designing interfaces that demonstrate and validate neuromodulation strategies to enforce a contingent and functional neural linkage between the central and the peripheral nervous system. We thus give clues to design systems that can improve or/and re-activate neuroplastic mechanisms and open a new recovery window for stroke patients.…”
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    Challenges of neural interfaces for stroke motor rehabilitation
  3. 4783
    “…These analyses exposed phenotypes for 3492 mutants, including 124 mutants of ‘priority unstudied’ proteins conserved in humans, providing varied functional clues. For example, over 900 proteins were newly implicated in the resistance to oxidative stress. …”
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    Broad functional profiling of fission yeast proteins using phenomics and machine learning
  4. 4784
    “…Although the full picture is still unfathomable, the molecular mechanisms have been elucidated for some of them, providing sufficient clues for intervention. In this article, we review the host defense mechanisms and bacterial evasion mechanisms and discuss the possibility of host-directed therapy for bacterial infection by intervening in the phagolysosome pathway.…”
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    Host-directed therapy for bacterial infections -Modulation of the phagolysosome pathway-
  5. 4785
    “…Subcellular localization of circRNA may provide some clues in elucidating its biological functions by performing subcellular fractionation assay. …”
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    Detection of Cytoplasmic and Nuclear Circular RNA via RT-qPCR
  6. 4786
    por Liu, Zesi, Jing, Chunli
    Publicado 2023
    “…Moreover, a novel pathogenic ABCA12 gene mutation may provide important clues for future research on the etiology of HI. …”
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    Two- and three-dimensional sonographic findings of harlequin ichthyosis: case report and literature review()
  7. 4787
    “…The diverse viral contigs closely related to mammals were assigned to 22 viral families. Molecular clues of the important rodent-borne viruses were further identified by polymerase chain reaction for phylogenetic analysis and annotation of genetic characteristics such as arenavirus, coronavirus, astrovirus, pestivirus, parvovirus, and papillomavirus. …”
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    Diversity and independent evolutionary profiling of rodent-borne viruses in Hainan, a tropical island of China
  8. 4788
    “…Thus, this work provides a better understanding of key factors to consider in a longitudinal study and provides clues for better strategies in clinical trial design.…”
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    Impact of follow ups, time interval and study duration in diffusion & myelin MRI clinical study in MS
  9. 4789
    “…Furthermore, we use parallel tempering in the well-tempered ensemble (PT-WTE) metadynamics simulations to characterize the in-solution conformation of iRGD and extensive molecular dynamics calculations to fully investigate its binding mechanism to integrin partners. Finally, we provide clues for fine-tuning the peptide’s potency and selectivity profile, which, in turn, may further improve its tumor-homing properties.…”
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    Molecular View on the iRGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles
  10. 4790
    “…Conclusion The identification of putative drivers or a candidate gene of a network could provide clues about the association with the disease phenotype of HNSCC. …”
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    Deciphering the Genetic Alteration in the ZEB2 Gene Network and Their Possible Association With Head and Neck Squamous Cell Carcinoma (HNSCC)
  11. 4791
    “…Our findings provide valuable insights into the roles of natural mutations on the PRV envelope glycoproteins in cell tropism, which sheds light on the relationship between cell tropism and clinical symptoms and offers clues about viral evolution.…”
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    The mutations on the envelope glycoprotein D contribute to the enhanced neurotropism of the pseudorabies virus variant
  12. 4792
    “…Bulk-sequencing of different gene transcripts by comparing HCC tissues and adjacent normal tissues provides some clues for investigating the mechanisms or identifying potential targets for tumor progression. …”
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    Galectin-14 promotes hepatocellular carcinoma tumor growth via enhancing heparan sulfate proteoglycan modification
  13. 4793
    “…Moreover, we discovered that the NC1 trimers encode information for homing protomers to distant tissue locations, providing clues for the development of protein replacement therapy for collagen IV genetic diseases.…”
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    Collagen IV of basement membranes: IV. Adaptive mechanism of collagen IV scaffold assembly in Drosophila
  14. 4794
    “…Positive in vivo selection of a brain-adapted strain of SIV resulted in a near-homogeneous strain of virus with distinct properties that may give clues to the viral basis of neuroAIDS.…”
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    Development and characterization of positively selected brain-adapted SIV
  15. 4795
    “…CONCLUSION: Immuno-analysis of the hydrophobic surfactant proteins and their precursor forms in bronchoalveolar lavage is minimally invasive and can give valuable clues for the involvement of processing abnormalities in pediatric pulmonary disorders.…”
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    Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease
  16. 4796
    “…The causal components driving the PM associations remain to be identified, but emerging evidence on particle size and chemistry has led to some clues. There is sufficient reason to believe that ultrafine particles < 0.1 μm (UFPs) are important because when compared with larger particles, they have order of magnitudes higher particle number concentration and surface area, and larger concentrations of adsorbed or condensed toxic air pollutants (oxidant gases, organic compounds, transition metals) per unit mass. …”
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    Exposure Assessment for Atmospheric Ultrafine Particles (UFPs) and Implications in Epidemiologic Research
  17. 4797
    “…The molecular changes that correspond with pathology changes are not well defined and identification of the molecular events may provide clues on the progression of intraepithelial neoplasia in the lung, as well as suggest potential targets for chemoprevention. …”
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    Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies
  18. 4798
    “…These patterns may provide clues about the main biological processes associated to different physiological states. …”
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    Biclustering of gene expression data by non-smooth non-negative matrix factorization
  19. 4799
    “…The phylogenetic information content of the comprehensive tree is substantially higher than that of any tree based on a single pathway, which also gave clues to constraints working on the topology of the global metabolic networks, information that is only partly reflected by the topologies of individual metabolic pathways.…”
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    Phylophenetic properties of metabolic pathway topologies as revealed by global analysis
  20. 4800
    “…Because ridges are fully formed by the end of the second trimester, they may provide clues to disturbed early development. The aim of this study was to assess these measures in a sample of patients with psychosis and normal controls. …”
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    Directional and fluctuating asymmetry in finger and a-b ridge counts in psychosis: a case-control study
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