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  1. 4821
    por Muzaffar, Neda E, Pearce, David A
    Publicado 2008
    “…Moreover, divergence of each protein shows a different pattern, providing important clues on the evolving role of these proteins. We present and review in-depth bioinformatic analysis of the NCL proteins and classify the CLN-proteins into families based on their structures and evolutionary relationships, respectively. …”
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    Analysis of NCL Proteins from an Evolutionary Standpoint
  2. 4822
    “…Our SP-C/c-raf transgenic mouse model revealed interesting and novel candidate genes and pathways that provide clues on the mechanism forcing respiratory epithelium into dysplasia and subsequently cancer, some of which might also be useful in the molecular imaging and flagging of early stages of disease.…”
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    Molecular Characterization of Lung Dysplasia Induced by c-Raf-1
  3. 4823
    “…The principal architectural elements observed by electron microscopy may represent useful morphological clues for identifying bacterial biofilms in vivo. …”
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    Characterization of structures in biofilms formed by a Pseudomonas fluorescens isolated from soil
  4. 4824
    “…Domain combination provides important clues to the roles of protein domains in protein function, interaction and evolution. …”
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    d-Omix: a mixer of generic protein domain analysis tools
  5. 4825
    “…Besides, our work could provide some clues to the evolution of the scorpion venom arsenal by comparison with venom data from other scorpion lineages.…”
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    Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal
  6. 4826
    “…However, we do have some clues as to why the damage, once initiated, progresses unabated. …”
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    Targeting the Progression of Parkinson’s Disease
  7. 4827
    “…Our data therefore indicate that a portion of nesfatin-1 neurons of both the hypothalamus and brainstem are sensitive to peripheral inflammatory signals, and provide the first clues suggesting that centrally released nesfatin-1 may contribute to the neural mechanisms leading to endotoxaemic anorexia.…”
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    Central nesfatin-1-expressing neurons are sensitive to peripheral inflammatory stimulus
  8. 4828
    “…Together, these findings provide new clues for future functional study of ncRNAs during development and evolution.…”
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    Systematic identification and characterization of chicken (Gallus gallus) ncRNAs
  9. 4829
    “…Such aggressive messages must trigger rapid attention to the periphery to allow a fast and adapted motor reaction. Several clues converge to hypothesize that peripheral danger presentation can trigger off a fast arousal network potentially independent of the consciousness spot. …”
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    Unconsciously Perceived Fear in Peripheral Vision Alerts the Limbic System: A MEG Study
  10. 4830
    “…CONCLUSIONS/SIGNIFICANCE: These studies indicate that general and organ-specific metabolism is transformed in response to mitochondrial dysfunction, including digestive and absorptive functions, and give important clues as to how novel therapeutic strategies for mitochondrial disorders might be developed.…”
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    Gene Expression in a Drosophila Model of Mitochondrial Disease
  11. 4831
    “…Analyses of data from interlaboratory studies conducted under a common standard operating procedure identified outlier data and provided clues to specific causes. Moreover, interlaboratory variation reflected by the metrics indicates which system components vary the most between laboratories. …”
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    Performance Metrics for Liquid Chromatography-Tandem Mass Spectrometry Systems in Proteomics Analyses
  12. 4832
    “…CONCLUSIONS: The findings presented here provide valuable tools for strain differentiation and phylogenetic studies of MV isolates and some clues as to the reasons for virus attenuation in the field.…”
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    Molecular characterisation of virulence graded field isolates of myxoma virus
  13. 4833
    “…Today, observation of amino acid composition in proteins has become an alternative way for a global understanding of the mystery encoded in whole genomes and seeking clues for the origin of amino acids. RESULTS: In this study, we statistically monitored the frequencies of 20 alpha-amino acids in 549 taxa from three kingdoms of life: archaebacteria, eubacteria, and eukaryotes. …”
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    Genome wide exploration of the origin and evolution of amino acids
  14. 4834
    “…Identification of the genes related to the very early stage of fulminant hepatitis development may provide precise clues for early diagnosis. RESULTS: Balb/C mice were used for ConA injection to induce fulminant hepatitis that was confirmed by pathological and biochemical examination. …”
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    Genes related to the very early stage of ConA-induced fulminant hepatitis: a gene-chip-based study in a mouse model
  15. 4835
    “…For 25 years, the nuclear functions of ICP0 have been the subject of intense scrutiny. To obtain new clues about ICP0's mechanism of action, we constructed HSV-1 viruses that expressed GFP-tagged ICP0. …”
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    ICP0 Dismantles Microtubule Networks in Herpes Simplex Virus-Infected Cells
  16. 4836
    “…Tests against the mammalian L6 cells revealed important clues on therapeutic index of the metabolites. This is the first detailed study on the antiprotozoal potential of marine bromopyrrole alkaloids.…”
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    Bromopyrrole Alkaloids as Lead Compounds against Protozoan Parasites
  17. 4837
    “…The supermarker thus identifies chromosomal features highly favored for retroviral integration, provides clues to the mechanism by which retrovirus integration sites are selected, and offers a tool for predicting cell-type specific proto-oncogene activation by retroviruses.…”
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    Deciphering the Code for Retroviral Integration Target Site Selection
  18. 4838
    “…We also discuss the current status of biological therapeutic strategies that promote disc regeneration and repair, and how lessons from development might provide clues for their refinement.…”
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    Degeneration and regeneration of the intervertebral disc: lessons from development
  19. 4839
    “…Structural and biophysical studies on these complexes are providing important clues to understand their function. To help improve our knowledge on protein-protein interactions within the Bcl-2 family we have studied the binding between two of its members: mouse Diva and human Harakiri. …”
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    Characterization of a Novel Interaction between Bcl-2 Members Diva and Harakiri
  20. 4840
    “…The subcellular localization (SCL) of a microbial protein provides clues about its function, its suitability as a drug, vaccine or diagnostic target and aids experimental design. …”
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    PSORTdb—an expanded, auto-updated, user-friendly protein subcellular localization database for Bacteria and Archaea
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