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  1. 4861
    por Rouault, Tracey A.
    Publicado 2012
    “…Finally, it outlines several important unresolved questions in the field that, once addressed, should offer important clues into how mitochondrial iron homeostasis is regulated, and how dysfunction in Fe-S cluster biogenesis can contribute to disease.…”
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    Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease
  2. 4862
    “…Thus, these findings provide new interesting clues for elucidation of mechanisms underlying the temperature acclimation in fish.…”
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    Transcriptomic Characterization of Temperature Stress Responses in Larval Zebrafish
  3. 4863
    “…Prior to predatory threat, different groups of rats were each tested on one of three object recognition memory tasks that varied in the types of contextual clues (i.e., that require the hippocampus or not) the rats could use to identify novel items. …”
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    A rat model of post-traumatic stress disorder reproduces the hippocampal deficits seen in the human syndrome
  4. 4864
    “…Recent data offer some clues on the mechanism that could explain the important role of PKCθ in NK cell-mediated anti-tumor immune surveillance: some studies show that PKCθ is implicated in signal transduction and anti-tumoral activity of NK cells elicited by interleukin (IL)-12 or IL-15, while others show that it is implicated in NK cell functional activation mediated by certain killer-activating receptors. …”
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    Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity
  5. 4865
    “…Finally, our phylogenetic analysis of haloarchaeal genomes provides clues about evolutionary relationships of haloarchaea.…”
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    The Complete Genome Sequence of Natrinema sp. J7-2, a Haloarchaeon Capable of Growth on Synthetic Media without Amino Acid Supplements
  6. 4866
    “…The association of mite hypersensitivity with aspirin/NSAIDs intolerance has been confirmed and provides additional clues to various nonallergic pathways that may contribute to the acute and chronic inflammatory process observed in atopic, mite-allergic, individuals. …”
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    Mite-induced inflammation: More than allergy
  7. 4867
    “…An understanding of the chronic effects of nicotine on excitatory and inhibitory metabolic demand, and corresponding neurotransmission may provide clues for designing strategies for the optimal smoking cessation intervention. …”
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    Glutamatergic and GABAergic Metabolism in Mouse Brain under Chronic Nicotine Exposure: Implications for Addiction
  8. 4868
    “…Understanding the formation and maintenance of latently infected cells could provide clues to eradicating this reservoir. However, there have been discrepancies regarding the susceptibility of resting cells to HIV infection in vitro and in vivo. …”
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    Directly Infected Resting CD4+T Cells Can Produce HIV Gag without Spreading Infection in a Model of HIV Latency
  9. 4869
    por Affleck, V.S., Coote, J.H., Pyner, S.
    Publicado 2012
    “…Understanding the anatomy and neurochemistry of NTS afferent connections within the PVN could provide important clues to the impairment in homeostasis cardiovascular control associated with disease. …”
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    The projection and synaptic organisation of NTS afferent connections with presympathetic neurons, GABA and nNOS neurons in the paraventricular nucleus of the hypothalamus
  10. 4870
    “…Such adverse effects may be prevented by administration of an appropriate form of vitamin B(6), or provide clues of how to modify these drugs to help reduce their hPL kinase inhibitory effects.…”
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    Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition
  11. 4871
    “…Here, we provide first clues of macroautophagy deregulation in lupus. By the use of LC3 conversion assays and electron microscopy experiments, we observed that T cells from two distinct lupus-prone mouse models, i.e., MRL(lpr/lpr) and (NZB/NZW)F1, exhibit high loads of autophagic compartments compared with nonpathologic control CBA/J and BALB/c mice. …”
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    Macroautophagy is deregulated in murine and human lupus T lymphocytes
  12. 4872
    “…However, the students' ability for pattern recognition is not as developed as in medical experts and complete history taking is often not repeated by an expert, so important clues may be missed. On the other hand, students' history taking is usually more extensive than experts' history taking and medical students discuss their findings with a Supervisor. …”
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    Effect of Supervised Students' Involvement on Diagnostic Accuracy in Hospitalized Medical Patients — A Prospective Controlled Study
  13. 4873
    por Priyadarshini, Sushri, Aich, Palok
    Publicado 2012
    “…Our comparative and systematic analysis of the published literature has unraveled certain interesting molecular mechanisms as clues to account for some of the observed effects of psychological stress on human physiology. …”
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    Effects of Psychological Stress on Innate Immunity and Metabolism in Humans: A Systematic Analysis
  14. 4874
    “…They have also given us clues into microbial community structures, dynamics, and functions at contaminated sites. …”
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    Ecogenomics of microbial communities in bioremediation of chlorinated contaminated sites
  15. 4875
    “…These novel findings provide clues for genes involved in economically important line characteristics of commercial laying hens.…”
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    Differential Gene Expression from Genome-Wide Microarray Analyses Distinguishes Lohmann Selected Leghorn and Lohmann Brown Layers
  16. 4876
    “…The results will contribute to our understanding on HIV recombination and provide clues to the identification of potential CRFs in China.…”
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    Recombination Form and Epidemiology of HIV-1 Unique Recombinant Strains Identified in Yunnan, China
  17. 4877
    “…More accurate estimates of the incidence thymoma in MG will help inform patients and their physicians, facilitate health policy discussions, provide etiologic clues, and optimize the management of MG. METHODS: We conducted a systematic review search of relevant English-language studies published between 1960 and 2012 using MEDLINE and Embase. …”
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    Incidence of Thymoma in Myasthenia Gravis: A Systematic Review
  18. 4878
    “…Knowledge of the clone sequences provides important clues about potential biotechnological application of the clones in the library; however, the sequencing of clones one-by-one would be very time-consuming and expensive. …”
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    Hybrid Sequencing Approach Applied to Human Fecal Metagenomic Clone Libraries Revealed Clones with Potential Biotechnological Applications
  19. 4879
    “…We furthermore provide direct clues that, in addition to the timing value per se, the shape of the timing profile at a given locus defines its set of genomic contacts. …”
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    3D chromatin conformation correlates with replication timing and is conserved in resting cells
  20. 4880
    “…These results provide some beneficial clues in structural modification for designing new inhibitors as dual-target–directed drugs with desired pharmacokinetic properties for the treatment of PD.…”
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    Molecular Docking and Prediction of Pharmacokinetic Properties of Dual Mechanism Drugs that Block MAO-B and Adenosine A(2A) Receptors for the Treatment of Parkinson's Disease
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