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  1. 4901
    “…In conclusion, this study for the first time demonstrated that the coexisting flavonoids have great protective effects against the POD toxicity, and results of this study highlighted the great potential of searching for effective antidotes against toxins based on the pharmacological clues.…”
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    Alleviation of Podophyllotoxin Toxicity Using Coexisting Flavonoids from Dysosma versipellis
  2. 4902
    “…At the same time, it provides new clues about the formation of revertant fibers/cardiomyocytes in dystrophic skeletal and cardiac muscle.…”
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    Revertant Fibers in the mdx Murine Model of Duchenne Muscular Dystrophy: An Age- and Muscle-Related Reappraisal
  3. 4903
    “…The lasting or lifelong effects of under-nutrition will depend on the period in the development at which it occurs. The clues that led Barker to his conclusions started to be discovered when he was studying the temporal trends in the incidence of ischemic heart disease in England and Wales. …”
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    Low birth weight: causes and consequences
  4. 4904
    “…The present study provides clues about the mechanism of action of tritripticin by using a unique monoclonal antibody (mAb) as a ‘physiological’ structural scaffold. …”
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    Putative Bioactive Motif of Tritrpticin Revealed by an Antibody with Biological Receptor-Like Properties
  5. 4905
    “…Principal components of the motions are dramatically different in the aqueous and in the membrane environments and provide clues regarding the conformational transitions that Bcl-xL undergoes in the membrane, in agreement with the biochemical data.…”
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    Dynamics of Bcl-xL in Water and Membrane: Molecular Simulations
  6. 4906
    “…Integration of transcriptome data into GWAS may provide clues elucidating the mechanisms by which a genetic variant leads to a disease. …”
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    New aQTL SNPs for the CYP2D6 Identified by a Novel Mediation Analysis of Genome-Wide SNP Arrays, Gene Expression Arrays, and CYP2D6 Activity
  7. 4907
    “…To date nothing is known about the subacute phase of neurodegeneration following injury in invertebrates. Among few clues available are the results published by our group reporting hemocytes and activated glial cells at chronic and acute phases of the lesion. …”
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    The Crustacean Central Nervous System in Focus: Subacute Neurodegeneration Induces a Specific Innate Immune Response
  8. 4908
    “…This transcriptome provides a quick way to understanding Paulownia, increases the number of gene sequences available for further functional genomics studies and provides clues to the identification of potential PaWB disease resistance genes. …”
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    Discovery of Genes Related to Witches Broom Disease in Paulownia tomentosa × Paulownia fortunei by a De Novo Assembled Transcriptome
  9. 4909
    “…Four melanomas and 2 nevi with different dermoscopic clues have been studied. Lesion areas that showed characteristic dermoscopic features were imaged by dermoscopy and confocal microscopy and directly correlated with histopathology in perpendicular and transverse sections. …”
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    Learning Reflectance Confocal Microscopy of Melanocytic Skin Lesions through Histopathologic Transversal Sections
  10. 4910
    “…Our findings implied that Bax may be a potential target gene of transcription factor Mipu1, and provided a novel insight for understanding the cytoprotection of HIF-1 and new clues for further elucidating the mechanisms by which Mipu1 protects cell against pathological stress.…”
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    Mipu1, a Novel Direct Target Gene, Is Involved in Hypoxia Inducible Factor 1-Mediated Cytoprotection
  11. 4911
    “…BACKGROUND: Genetic modifiers are important clues for the identification of therapeutic targets in neurodegenerative diseases. …”
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    A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort
  12. 4912
    “…Additionally, we found strong clues for mating during fall. Summer survival that included two major migratory journeys was identical to winter survival in males and slightly higher in females, suggesting that the migratory journeys did not bear significant costs in terms of survival. …”
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    Seasonal Survival Probabilities Suggest Low Migration Mortality in Migrating Bats
  13. 4913
    “…The findings of the present study clearly indicate the crucial role of p38 and JNK pathways in embelin induced apoptosis and provide us with new clues for improving its therapeutic efficacy.…”
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    Activation of p38/JNK Pathway Is Responsible for Embelin Induced Apoptosis in Lung Cancer Cells: Transitional Role of Reactive Oxygen Species
  14. 4914
    “…We will review the mechanisms and roles of mtDNA homoplasmy, in contrast to nuclear gene conversion, which diversifies gene and genome sequences, to provide clues toward understanding how the common DNA processing pathway results in such divergent outcomes.…”
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    Enlightenment of Yeast Mitochondrial Homoplasmy: Diversified Roles of Gene Conversion
  15. 4915
    “…The differentially regulated transcripts include >60 encoding proteins that may play roles in transporting various nutrients between the symbiotic partners; many more encoding proteins functioning in several metabolic pathways, providing clues regarding how the transported nutrients may be used by the partners; and several encoding proteins that may be involved in host recognition and tolerance of the dinoflagellate.…”
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    Extensive Differences in Gene Expression Between Symbiotic and Aposymbiotic Cnidarians
  16. 4916
    “…Combined with previous reports of increased excitatory and inhibitory synaptic currents in RGCs, these results provide clues to understand the mechanism underlying the aberrant spiking in RGCs.…”
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    Loss of Photoreceptors Results in Upregulation of Synaptic Proteins in Bipolar Cells and Amacrine Cells
  17. 4917
    “…These biochemical findings provide clues to understanding how YaeJ enters the A-site of stalled ribosomes.…”
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    Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ
  18. 4918
    “…In particular, metabolic flux analysis provided new clues to understand the metabolic regulation mediated by the ArcBA and CreBC systems. …”
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    Escherichia coli redox mutants as microbial cell factories for the synthesis of reduced biochemicals
  19. 4919
    “…Investigations of mtDNA regions affected by rearrangements (i.e. breakpoints) can lead to important discoveries about rearrangement mechanisms and can offer important clues about the causes of mitochondrial diseases. …”
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    MitoBreak: the mitochondrial DNA breakpoints database
  20. 4920
    “…This study provides basic knowledge regarding fish IFN-γ-induced miRNAs and offers clues for further studies into the mechanisms underlying fish IFN-γ-mediated immune responses.…”
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    Differential Expression Profiling of Spleen MicroRNAs in Response to Two Distinct Type II Interferons in Tetraodon nigroviridis
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