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  1. 4981
    “…Our work highlights a new mode of inheritance underlay the genetic etiology of KS and provide valuable clues to understand the disease development.…”
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    Point mutations in KAL1 and the mitochondrial gene MT-tRNA(cys) synergize to produce Kallmann syndrome phenotype
  2. 4982
    por Li, Ping, Nie, Yaling, Yu, Jingkai
    Publicado 2015
    “…The identified shared pathways and common modules can be expected to yield clues for effective target discovery efforts on neurodegeneration.…”
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    An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases
  3. 4983
    “…When a young female with no past or family history of mental illness presents with psychotic features, unprovoked panic, and limbic symptoms always ask for minor or transient symptoms and signs referable to the other systems which might give valuable clues.…”
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    New Onset Psychosis as The First Manifestation of Neuro-Psychiatric Lupus. A Situation Causing Diagnostic Dilemma
  4. 4984
    “…This study provided important clues that dysbiosis of the oral microbiota might be involved in the development of HBV-CLD. …”
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    Decreased Diversity of the Oral Microbiota of Patients with Hepatitis B Virus-Induced Chronic Liver Disease: A Pilot Project
  5. 4985
    “…The current study provides some clues into the mechanisms underlying the dissemination of L. tropica.…”
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    Comparative Proteomic Profiling of Leishmania tropica: Investigation of a Case Infected with Simultaneous Cutaneous and Viscerotropic Leishmaniasis by 2-Dimentional Electrophoresis and Mass Spectrometry
  6. 4986
    “…Our findings provide important information regarding the impact of HIV/SIV infection on Tfh cells, and provide new clues for future vaccine strategies.…”
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    Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques
  7. 4987
    “…We also showed that NS5A effected a loss of EGFR ubiquitination in a P2-motif-dependent fashion. These data provide clues to the mechanism by which NS5A regulates the trafficking of a key cellular receptor and demonstrate for the first time the ability of NS5A to regulate host cell ubiquitination pathways.…”
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    Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction
  8. 4988
    “…Our findings provide important clues towards understanding the mechanisms underlying biases between social groups.…”
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    Neural correlates of biased social fear learning and interaction in an intergroup context
  9. 4989
    “…Here, we utilized RNA-seq technology to perform a genome-wide analysis of miRNAs from the adipose tissue of the two species of sheep to look for clues that might explain the fat deposition differences between the sheep. …”
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    Genome-wide analysis of microRNAs identifies the lipid metabolism pathway to be a defining factor in adipose tissue from different sheep
  10. 4990
    “…The identified inhibitory chemicals could provide novel clues to elucidate the regulatory mechanisms underlying anhydrobiosis in tardigrades.…”
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    Suggested Involvement of PP1/PP2A Activity and De Novo Gene Expression in Anhydrobiotic Survival in a Tardigrade, Hypsibius dujardini, by Chemical Genetic Approach
  11. 4991
    “…Taken together, our findings identified C/EBPβ and CREB as the important regulators of porcine Prdx6 gene expression, and offered clues for further investigation of Prdx6 gene function.…”
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    The Expression of Porcine Prdx6 Gene Is Up-Regulated by C/EBPβ and CREB
  12. 4992
    por Guo, Liyuan, Du, Yang, Qu, Susu, Wang, Jing
    Publicado 2016
    “…In summary, rVarBase hosts more types of human variants and includes more types of up-to-date regulatory information to facilitate in-depth functional research and to provide practical clues for experimental design.…”
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    rVarBase: an updated database for regulatory features of human variants
  13. 4993
    “…We sought to explore whether the preclinical results supporting bisphosphonate use provided clues to help explain the current clinical data. …”
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    Adjuvant bisphosphonate treatment for breast cancer: Where are we heading and can the pre-clinical literature help us get there?
  14. 4994
    “…Understanding the role of vitamin B(12) and omega-3 fatty acids on brain functioning may provide important clues to prevent early cognitive deficits and later neurobehavioral disorders.…”
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    Novel insights into the effect of vitamin B(12) and omega-3 fatty acids on brain function
  15. 4995
    “…These results provide strong clues on the role of GDH in intracellular survival of M. tuberculosis, in which the essentiality of the gdh gene complicates knock out studies making the study of the role of this enzyme in pathogenesis difficult.…”
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    Glutamate Dehydrogenase Is Required by Mycobacterium bovis BCG for Resistance to Cellular Stress
  16. 4996
    “…Besides, asymmetric supercapacitor devices and applications were also explored. The scientific clues and practical potentials obtained in this work are helpful for the design and analysis of alternative core/shell electrode materials.…”
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    Chemical insights into the roles of nanowire cores on the growth and supercapacitor performances of Ni-Co-O/Ni(OH)(2) core/shell electrodes
  17. 4997
    “…Our findings provide new clues to understanding the risk of rhabdomyolysis following exercise in human VLCADD.…”
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    Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency
  18. 4998
    “…Therefore, molecular dissection of mSSC reprogramming may provide clues about novel endogenous reprogramming or pluripotency regulatory factors. …”
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    An integrated systems biology approach identifies positive cofactor 4 as a factor that increases reprogramming efficiency
  19. 4999
    “…ECM changes appear to be important factors in potentiating aging-related phenotypes and may provide clues to mechanisms that allow for aging-related lung diseases.…”
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    Decreased Laminin Expression by Human Lung Epithelial Cells and Fibroblasts Cultured in Acellular Lung Scaffolds from Aged Mice
  20. 5000
    “…TNC mutation, no hypermethylation of RASSF1A, and GFAP/NeuN expression may be diagnostic clues of posterior fossa ependymoma. Although MEN1, TP53, and PTEN mutations are rarely reported in ependymoma, they may be related to a poor prognosis, such as recurrence or metastasis. …”
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    The Similarities and Differences between Intracranial and Spinal Ependymomas : A Review from a Genetic Research Perspective
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