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  1. 5241
    “…This concept also provides clues regarding the importance of platelet function in relation to cardiovascular disease. …”
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    Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding
  2. 5242
    “…This might offer precious tools for preventive strategies and possible clues on the evolution of the disease and could help in predicting morbidity, mortality and detecting chronic disease indicators much earlier in the disease course. …”
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    Precision and Personalized Medicine: How Genomic Approach Improves the Management of Cardiovascular and Neurodegenerative Disease
  3. 5243
    “…CONCLUSIONS: Co-expression of CDK1 and CDCA5 might confer cell proliferation, migration, and invasion abilities in GC cells, and this can provide some clues for further therapies of gastric tumors.…”
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    Cyclin-Dependent Kinase 1 (CDK1) is Co-Expressed with CDCA5: Their Functions in Gastric Cancer Cell Line MGC-803
  4. 5244
    “…The proposed biochemical mechanisms based on our findings provide important clues to how additional physiological roles for DPs and proteins harboring dirigent-like domains can now be rationally and systematically identified.…”
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    Pterocarpan synthase (PTS) structures suggest a common quinone methide–stabilizing function in dirigent proteins and proteins with dirigent-like domains
  5. 5245
    “…With computational approaches we show that it is possible, by starting from the enzyme structure, to highlight clues of their multiple roles in different pathways and of putative mechanisms promoting the association of genes to disease.…”
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    Highlighting Human Enzymes Active in Different Metabolic Pathways and Diseases: The Case Study of EC 1.2.3.1 and EC 2.3.1.9
  6. 5246
    “…Moreover, we inferred clues on their functions based on correlation analyses and predicted interactions with RNA-binding proteins, microRNAs, and mRNAs. …”
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    Comprehensive Analysis of LincRNAs in Classical and Basal-Like Subtypes of Pancreatic Cancer
  7. 5247
    “…Unique features present in the SDRs help provide clues about how SDRs are established and how they evolve in the absence of recombination. …”
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    Sequencing and Analysis of the Sex Determination Region of Populus trichocarpa
  8. 5248
    “…Our results suggest that NGAL and NGAL-R, overexpressed in untreated CLL, participate in the deregulation of the apoptotic machinery in CLL cells, and may be potential therapeutic clues for CLL treatment.…”
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    Relation of Neutrophil Gelatinase-Associated Lipocalin Overexpression to the Resistance to Apoptosis of Tumor B Cells in Chronic Lymphocytic Leukemia
  9. 5249
    “…Alterations in circulating lipids and BCAAs were associated with the risk of arterial stiffness in the middle-aged Chinese population. Our findings provide clues to understanding the potential mechanisms of subclinical atherosclerosis; however, further validation in a broader population context and the exploration of potential clinical applications are warranted.…”
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    Associations between serum metabolites and subclinical atherosclerosis in a Chinese population: the Taizhou Imaging Study
  10. 5250
    “…This study provides new clues for the discovery of IDO1/TDO2 inhibitors with novel scaffolds.…”
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    Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening
  11. 5251
    por Seimiya, Hiroyuki
    Publicado 2020
    “…Collectively, telomere biology has provided clues for deeper understanding of cancer, which expands opportunities to discover innovative anticancer drugs.…”
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    Crossroads of telomere biology and anticancer drug discovery
  12. 5252
    “…In this review, we mainly highlight the current possible factors predisposing individuals to PRH, particularly related to the gut microbiota, which may yield significant insights into the intestinal regulation of glucose metabolic homeostasis and provide novel clues to improve the treatment of type 2 diabetes mellitus.…”
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    Potential contribution of the gut microbiota to hypoglycemia after gastric bypass surgery
  13. 5253
    “…This study aimed to identify the clinical or radiologic clues indicative of FPAM on DSA. METHODS: Patients who had undergone DSA between 2016 and 2019 for suspicious aneurysm-like structures < 5 mm in size on MRA were enrolled. …”
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    Features of “false positive” unruptured intracranial aneurysms on screening magnetic resonance angiography
  14. 5254
    “…Moreover, the dynamic changes in the expression of the selected signature genes in EMT may provide clues to the link between EMT and clinical outcomes of breast cancer. scPrognosis will also be useful when applied to scRNA-seq datasets of different biological processes other than EMT.…”
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    A novel single-cell based method for breast cancer prognosis
  15. 5255
    “…These findings may provide new clues for the treatment of sarcomas.…”
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    The Study of Sarcoma Microenvironment Heterogeneity Associated With Prognosis Based on an Immunogenomic Landscape Analysis
  16. 5256
    “…Ever since the availability of genomes from Neanderthals, Denisovans, and ancient humans, the field of evolutionary genomics has been searching for protein-coding variants that may hold clues to how our species evolved over the last ∼600,000 years. …”
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    Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels
  17. 5257
    “…These results provide clues for developing safe anti-JEV/ZIKV vaccines.…”
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    Japanese encephalitis virus–primed CD8(+) T cells prevent antibody-dependent enhancement of Zika virus pathogenesis
  18. 5258
    “…In conclusion, the experimental results of the present study could provide important clues for investigating the mechanism of MI.…”
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    MiR-489 aggravates H(2)O(2)-induced apoptosis of cardiomyocytes via inhibiting IGF1
  19. 5259
    “…The molecules secreted by RACs, such as exosomes, have recently received a lot of attention and may provide potential clues to address the RAC‐mediated modulation of endothelial cells. …”
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    Oxidative stress‐induced RAC autophagy can improve the HUVEC functions by releasing exosomes
  20. 5260
    “…How these different olfactory clues are combined to optimize decision-making concerning food selection remains elusive. …”
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    The Grueneberg ganglion controls odor-driven food choices in mice under threat
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