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  1. 5281
    “…The analysis pipeline can effectively unveil cancer- and cell-specific modules of epigenetic dysregulation, and such modules may provide novel clues for identifying diagnostic, therapeutic, and prognostic targets for epigenetic dysregulation.…”
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    Extended transcriptome analysis reveals genome-wide lncRNA-mediated epigenetic dysregulation in colorectal cancer
  2. 5282
    “…These changes align with sociological theories of health disparities and contain important clues for more fully understanding the autism epidemic.…”
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    The social patterning of autism diagnoses reversed in California between 1992 and 2018
  3. 5283
    por Nunomura, Akihiko, Perry, George
    Publicado 2020
    “…Focusing on a neuroprotective transcriptional repressor, REST, and the concept of hormesis that are relevant to the OS response may provide clues to help us understand the role of the miRNA system in cellular and organismal adaptive mechanisms to OS.…”
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    RNA and Oxidative Stress in Alzheimer's Disease: Focus on microRNAs
  4. 5284
    “…This work provides insights on how Leonardo obtained these grades of pigment and proposes new clues regarding the optical and/or working properties he may have tried to achieve.…”
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    Microchemical analysis of Leonardo da Vinci’s lead white paints reveals knowledge and control over pigment scattering properties
  5. 5285
    “…Our results suggest a unique modulatory capacity of dopaminergic-related genes that may favor mobility resilience and predict better response to therapy. Our data provide clues for novel targeted interventions to delay physical disability in older adults.…”
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    Dopaminergic Signaling: Driver of Mobility Resilience and Moderator of Response to Pharmacotherapy
  6. 5286
    “…Taken together, we propose two distinctive salt tolerance mechanisms in Clipper (growth-sustaining) and Sahara (salt-shielding), providing important clues for improving crop plasticity to cope with deteriorating global soil salinization.…”
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    Integrative Multi-omics Analyses of Barley Rootzones under Salinity Stress Reveal Two Distinctive Salt Tolerance Mechanisms
  7. 5287
    “…The results would provide clues for establishing the appropriate animal model in the research and clinical cure of COVID-19.…”
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    Bioinformatic evaluation of the potential animal models for studying SARS-Cov-2
  8. 5288
    “…Taken together, HES1 promotes BCSC stemness properties via targeting Slug, highlighting that HES1 might be a novel candidate for BCSC stemness regulation in TNBC and providing new clues for identifying promising prognostic biomarkers and therapeutic targets of TNBC.…”
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    HES1 promotes breast cancer stem cells by elevating Slug in triple-negative breast cancer
  9. 5289
    “…This study aimed to identify the association between the interactions of single nucleotide polymorphisms (SNPs) in RAS family genes and PTC in the Han Chinese population, to provide clues to the pathogenesis and potential therapeutic targets for PTC. …”
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    Association analysis between the interaction of RAS family genes mutations and papillary thyroid carcinoma in the Han Chinese population
  10. 5290
    “…Given the known importance of MOR1 in basal ganglia signaling, our findings, though in mice, should offer clues to the pathogenesis of psychiatric features, especially depression, reinforcement sensitivity, and involuntary movements in HD.…”
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    Spatiotemporal Up-Regulation of Mu Opioid Receptor 1 in Striatum of Mouse Model of Huntington’s Disease Differentially Affecting Caudal and Striosomal Regions
  11. 5291
    “…These insights into the molecular mechanism of activation of TipA proteins advance our understanding of TipA proteins, as well as bacterial MDR systems, and may provide important clues to block bacterial resistance.…”
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    Antibiotic binding releases autoinhibition of the TipA multidrug-resistance transcriptional regulator
  12. 5292
    “…Put together, we identify potential new strategies for targeting latent tuberculosis, new candidate drug targets as well as important lead clues for drug design.…”
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    A Multi-Pronged Computational Pipeline for Prioritizing Drug Target Strategies for Latent Tuberculosis
  13. 5293
    “…Organic molecules from the urine combine with mineral crystals to form stones, but analysis of the stone matrix has revealed over a thousand different proteins, with no clues as to which are important for stone growth. …”
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    Demineralization and sectioning of human kidney stones: A molecular investigation revealing the spatial heterogeneity of the stone matrix
  14. 5294
    “…This study provides new clues for the discovery of anti-obesity molecules from natural products.…”
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    Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes
  15. 5295
    “…This study may provide valuable clues to investigate the interaction of host genetic variations and gut microbiota in the pathogenesis of ASD.…”
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    Gene variations in Autism Spectrum Disorder are associated with alternation of gut microbiota, metabolites and cytokines
  16. 5296
    “…Here it is important for the pathologist to correctly identify potential accompanying histological characteristics in order to be able to provide clues to a possible cause of OP.…”
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    Kryptogen organisierende Pneumonie versus sekundäre organisierende Pneumonie
  17. 5297
    “…Our study might provide some useful clues to a better understanding of GLI3 in EMT during CRC progression.…”
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    GLI3 Promotes Invasion and Predicts Poor Prognosis in Colorectal Cancer
  18. 5298
    “…Therefore, the worm may provide important clues to better understand cell invasion and metastasis formation in humans.…”
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    To Divide or Invade: A Look Behind the Scenes of the Proliferation-Invasion Interplay in the Caenorhabditis elegans Anchor Cell
  19. 5299
    por Argyriou, Thodoris, Davesne, Donald
    Publicado 2021
    “…At the same time, the scarcity of Paleocene findings offers tentative clues for a depauperate state of Tethyan ichthyofaunas in the aftermath of the K–Pg Extinction.…”
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    Offshore marine actinopterygian assemblages from the Maastrichtian–Paleogene of the Pindos Unit in Eurytania, Greece
  20. 5300
    “…Our comprehensive assessment of host signaling in SARS-CoV-2 pathogenesis provides some complex yet important strategic clues for the development of novel therapeutics against this rapidly emerging worldwide crisis.…”
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    Dysregulation of Cell Signaling by SARS-CoV-2
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