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  1. 5501
    “…Through protein–protein interaction analysis, 65 genes were identified that might be involved in JAZ8 regulation of resistance to P. brassicae in B. napus, which provided new clues for understanding the resistance mechanism to P. brassicae.…”
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    Genome-Wide Identification and Variation Analysis of JAZ Family Reveals BnaJAZ8.C03 Involved in the Resistance to Plasmodiophora brassicae in Brassica napus
  2. 5502
    “…This work may provide one of the possible clues to explain the α-Syn mutant-type dependent pathological heterogeneity of familial PD.…”
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    α-Synuclein Disrupts Vesicle Fusion by Two Mutant-Specific Mechanisms
  3. 5503
    “…Immunoprecipitation experiments demonstrated an association of HTT with junctophilin 1 (JPH1) and stromal interaction molecule 1 (STIM1), both providing clues on the functional effects of HTT deletion on calcium fluxes. …”
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    Huntingtin regulates calcium fluxes in skeletal muscle
  4. 5504
    “…The rat model provides clues on the molecular and cellular mechanisms underlying XLRS pathology in this model and points to a substantial and early changes to normal retinal development.…”
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    XLRS Rat with Rs1(-/Y) Exon-1-Del Shows Failure of Early Postnatal Outer Retina Development
  5. 5505
    “…Therefore, our results not only provide a good reference genome to conduct further molecular biological studies in Epimedium genus, but also give important clues for synthetic biology and industrial production of related prenylated flavonoids in future.…”
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    The discovery of a key prenyltransferase gene assisted by a chromosome-level Epimedium pubescens genome
  6. 5506
    “…CONCLUSION: ESCA-associated AS factors hnRNP G and Fox-2 are of great value in deciphering the underlying mechanisms of AS in ESCA and providing clues for therapeutic goals for further validation.…”
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    The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer
  7. 5507
    “…Mathematical modeling of these networks provides important clues, but the models themselves are often complex, and it is not always clear how to extract falsifiable predictions. …”
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    Deduction of signaling mechanisms from cellular responses to multiple cues
  8. 5508
    “…These results provided clues for future microbial-based therapies on CSU.…”
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    Gut Microbiome Alterations and Functional Prediction in Chronic Spontaneous Urticaria Patients
  9. 5509
    “…Her complex complications of hypothyroidism and cerebrovascular abnormalities contributed to more challenges, which were also clues to the diagnosis. With prompt and active treatment, the patient recovered fully over 10 days. …”
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    An unusual contrast-induced encephalopathy following percutaneous coronary intervention in patients with cerebrovascular abnormalities: A case report
  10. 5510
    “…It also proposes particular clues and strategies that could help experts cope with this risk and avoid making biased decisions.…”
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    How to Minimize the Impact of Experts’ Non-rational Beliefs on Their Judgments on Autism
  11. 5511
    “…Altogether, these data provide clues on the mechanisms likely contributing to the beneficial impact of FCH on human skin functionality by supporting hydration, elasticity and limiting the expression of catabolic factors involved in photoaging onset.…”
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    Benefits of Circulating Human Metabolites from Fish Cartilage Hydrolysate on Primary Human Dermal Fibroblasts, an Ex Vivo Clinical Investigation for Skin Health Applications
  12. 5512
    “…The above results provide important clues for further studies on the role of IbBBX28 in regulating the stress response in sweet potato.…”
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    The sweet potato B-box transcription factor gene IbBBX28 negatively regulates drought tolerance in transgenic Arabidopsis
  13. 5513
    “…Although it remains to decipher all key factors involved in the ambivalent role of this ligand, accumulating clues suggest that while the membrane bound CD95L triggers apoptosis, its soluble counterpart generated by metalloprotease-driven cleavage is responsible for its non-apoptotic functions. …”
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    Role of metalloproteases in the CD95 signaling pathways
  14. 5514
    “…Our results offer many promising clues for translational research aimed to define molecular bases, diagnostic biomarkers, and specific therapies for these challenging connective tissue disorders.…”
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    RNA-Seq of Dermal Fibroblasts from Patients with Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorders Supports Their Categorization as a Single Entity with Involvement of Extracellular Matrix Degrading and Proinflammatory Pathomechanisms
  15. 5515
    “…In conclusion, our findings provided insights into how entinostat improves the efficacy of ionizing radiation plus anti-PD-1 therapy and offered clues for developing new strategies for clinical trials.…”
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    Immunomodulation of HDAC Inhibitor Entinostat Potentiates the Anticancer Effects of Radiation and PD-1 Blockade in the Murine Lewis Lung Carcinoma Model
  16. 5516
    “…CONCLUSION: We provide evidence that NETs may play a role in anti-NMDAR encephalitis, providing clues for elucidation of the pathogenesis of this disease.…”
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    Increased formation of neutrophil extracellular traps in patients with anti-N-methyl-d-aspartate receptor encephalitis
  17. 5517
    “…Conclusions: Consequently, these data provide some new clues for the clinical development of combination therapy with OVs, epigenetic modifiers, and checkpoint blockades for glioma and squamous cell carcinoma.…”
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    Histone Deacetylase Inhibitor Panobinostat Benefits the Therapeutic Efficacy of Oncolytic Herpes Simplex Virus Combined with PD-1/PD-L1 Blocking in Glioma and Squamous Cell Carcinoma Models
  18. 5518
    “…Understanding salt tolerance mechanisms will provide clues for breeding salt‐tolerant plants. Many halophytes, such as quinoa (Chenopodium quinoa), are covered by a layer of epidermal bladder cells (EBCs) that are thought to mediate salt tolerance by serving as salt dumps. …”
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    The epidermal bladder cell‐free mutant of the salt‐tolerant quinoa challenges our understanding of halophyte crop salinity tolerance
  19. 5519
    “…The study found that affective pruritus decreases patient’s quality of life either directly or indirectly through sleep disturbance. In conclusion, clues about a patients’ sleep disturbance or poor quality of life can be obtained through their descriptions of pruritus.…”
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    Validation of Relationship between Patients’ Descriptions of Pruritus and Patient-burden of Chronic Pruritus using Structural Equation Modelling
  20. 5520
    “…Information such as spatial heterogeneity of genes and cells, cell-cell communication activities in space, and the cell type compositions in the microenvironment are critical clues to unveil the mechanism of tumorigenesis and embryo differentiation. …”
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    SPASCER: spatial transcriptomics annotation at single-cell resolution
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