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  1. 5661
    por Mak, Johnson
    Publicado 2005
    “…A number of recent reports have provided tantalizing clues to support the view that RNA silencing functions as a physiological response to regulate viral infection in vertebrate cells. …”
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    RNA interference: more than a research tool in the vertebrates' adaptive immunity
  2. 5662
    “…Large-scale studies such as the National Children’s Study may provide some important clues. The human neurodevelopmental phenotype will be most clearly represented in models that include environmental chemical exposures, the social milieu, and complex human genetic characteristics that we are just beginning to understand.…”
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    Principles and Practices of Neurodevelopmental Assessment in Children: Lessons Learned from the Centers for Children’s Environmental Health and Disease Prevention Research
  3. 5663
    “…This represents the first comprehensive analysis of novel genes in prokaryotic genomic islands and provides clues regarding the origin of novel genes. Our collective results imply that there are different gene pools associated with recently horizontally transmitted genomic regions versus regions that are primarily vertically inherited. …”
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    Evidence of a Large Novel Gene Pool Associated with Prokaryotic Genomic Islands
  4. 5664
    “…Evidence concerning therapy is very poor, but epidemiological data from this study may provide helpful clues to select empiric antifungal therapy in neutropenic enterocolitis.…”
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    Invasive fungal infections in neutropenic enterocolitis: A systematic analysis of pathogens, incidence, treatment and mortality in adult patients
  5. 5665
    “…CONCLUSION: The genes comprising the cell-type specific signatures encompassed many of the genes already known to be involved in cell-type specific processes, and provided clues that may prove useful in discovering the functions of many still unannotated genes. …”
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    Cell-type specific gene expression profiles of leukocytes in human peripheral blood
  6. 5666
    “…These discoveries could provide clues to important physiologic adaptations underlying the body mass response to CHO restriction.…”
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    Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction
  7. 5667
    “…A detailed analysis of phosphoinositide signaling may provide valuable clues for better understanding the pathogenesis of tularemia.…”
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    Macrophage Pro-Inflammatory Response to Francisella novicida Infection Is Regulated by SHIP
  8. 5668
    “…Identification of these should provide endpoints useful for optimizing stem cell propagation as well as potential clues about mechanisms governing stem cell maintenance. …”
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    Meta-Analysis of Differentiating Mouse Embryonic Stem Cell Gene Expression Kinetics Reveals Early Change of a Small Gene Set
  9. 5669
    “…The coupling of spacing to tissue specificity at the transcriptome level provides important clues as to the function of core promoters and the choice of TSS by the pre-initiation complex.…”
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    Transcriptional and structural impact of TATA-initiation site spacing in mammalian core promoters
  10. 5670
    “…Splicing correlations within transcripts of single genes provide valuable clues to functional relationships among molecular domains as well as genomic targets for higher-order splicing regulation. …”
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    Multivariate Analysis and Visualization of Splicing Correlations in Single-Gene Transcriptomes
  11. 5671
    “…Fortunately, a variety of novel high-throughput genome-wide functional screening technologies provide important clues that shed light on gene function. The integration of heterogeneous data to predict protein function has been shown to improve the accuracy of automated gene annotation systems. …”
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    Probabilistic Protein Function Prediction from Heterogeneous Genome-Wide Data
  12. 5672
    “…Moreover, this paper provides evidence for the influence of natural selection at synonymous sites in the mouse genome and novel clues for linking the molecular features of genes to their patterns of expression during mammalian ontogenesis.…”
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    Developmental stage related patterns of codon usage and genomic GC content: searching for evolutionary fingerprints with models of stem cell differentiation
  13. 5673
    por Spitz, Lewis
    Publicado 2007
    “…The aetiology is largely unknown and is likely to be multifactorial, however, various clues have been uncovered in animal experiments particularly defects in the expression of the gene Sonic hedgehog (Shh). …”
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    Oesophageal atresia
  14. 5674
    por Forgie, Sarah E, Robinson, Joan L
    Publicado 2007
    “…However, pediatric infectious diseases physicians should consider malignancy in the differential diagnosis when they see patients with fever and bone pain, unexplained splenomegaly or abnormal complete blood cell counts. Other clues may include hepatomegaly or elevated LDH.…”
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    Pediatric malignancies presenting as a possible infectious disease
  15. 5675
    “…Despite these differences, the conserved regulation of a core set of genes involved in the uptake of these metals provides valuable clues to key features of metal metabolism.…”
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    Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study
  16. 5676
    por Moczek, Armin P
    Publicado 2007
    “…More generally, adult morphology alone appears to provide few clues, if any, as to the relative contributions of both processes to the expression of alternative male morphs, underscoring the importance of developmental studies in efforts aimed at understanding the evolution of adult diversity patterns.…”
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    Pupal remodeling and the evolution and development of alternative male morphologies in horned beetles
  17. 5677
    “…Application of this rule to mass spectrometric analyses provides predictive clues to the presence of specific molecular species and greatly expands the number of identifiable and quantifiable ether lipid species present in biological samples. …”
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    Shotgun Lipidomics Identifies a Paired Rule for the Presence of Isomeric Ether Phospholipid Molecular Species
  18. 5678
    Publicado 1994
    “…The experimental cell model, which we describe here, provides not only a means to study nef function in vitro, but also provides important clues to the function of nef in HIV infection in vivo.…”
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    The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes
  19. 5679
    “…Gene expression patterns can provide vital clues to the pathogenesis of neoplastic diseases. …”
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    Interleukin 13 Is Secreted by and Stimulates the Growth of Hodgkin and Reed-Sternberg Cells
  20. 5680
    “…CONCLUSION: A molecular description of gene expression changes occurring in the brain throughout the course of neuronal ceroid lipofuscinosis suggests distinct phases of disease progression, provides clues to potential markers of disease activity, and points to new targets for therapy.…”
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    Gene expression profiling in a mouse model of infantile neuronal ceroid lipofuscinosis reveals upregulation of immediate early genes and mediators of the inflammatory response
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