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  1. 5741
    “…In addition to or instead of that function, we propose that their sex-limited expression, coupled with their rapid evolution may be clues to an as-yet-undetermined interaction between the sexes.…”
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    Positive Selection Shaped the Convergent Evolution of Independently Expanded Kallikrein Subfamilies Expressed in Mouse and Rat Saliva Proteomes
  2. 5742
    “…Further diagnostic work up and/or procedures were requested according to the potential diagnostic clues (PDC) present in every patient. RESULTS: Out of 100 FUO patients, 50% were found to have infectious diseases, 24% were found to have connective tissue diseases, 8% miscellaneous causes and 7% neoplastic diseases (P < 0.05). …”
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    Prevalence of Connective Tissue Diseases in Egyptian Patients Presenting with Fever of Unknown Origin
  3. 5743
    “…Our results reveal that ORP8 has the capacity to modulate lipid homeostasis and SREBP activity, probably through an indirect mechanism, and provide clues of an entirely new mode of ORP action.…”
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    OSBP-Related Protein 8 (ORP8) Regulates Plasma and Liver Tissue Lipid Levels and Interacts with the Nucleoporin Nup62
  4. 5744
    “…CONCLUSION/SIGNIFICANCE: This study provides important clues for designing AmiRs targeting the 3′UTR of viral genome. …”
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    Targeted Delivery of Mutant Tolerant Anti-Coxsackievirus Artificial MicroRNAs Using Folate Conjugated Bacteriophage Phi29 pRNA
  5. 5745
    “…On the basis of analysis of regions of differences (RDs) across the entire genome for the 18 selected SS2 strains, a model of microevolution for these strains is proposed, which provides clues into Streptococcus pathogenicity and evolution. …”
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    Probing genomic diversity and evolution of Streptococcus suis serotype 2 by NimbleGen tiling arrays
  6. 5746
    “…Such organization is reflective of the presumed eumetazoan ancestor and might provide clues for the evolution of centralization in the nervous system. …”
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    Correct anteroposterior patterning of the zebrafish neurectoderm in the absence of the early dorsal organizer
  7. 5747
    “…These findings suggest that NAD and SIRT1 mediate the protective function of Wld(S) against the cytotoxicity induced by paraquat, which provides new clues for the mechanisms underlying the protective function of Wld(S) in both neuronal and non-neuronal cells, and implies that attenuation of NAD depletion may be effective to alleviate paraquat poisoning.…”
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    Wld(S) Reduces Paraquat-Induced Cytotoxicity via SIRT1 in Non-Neuronal Cells by Attenuating the Depletion of NAD
  8. 5748
    “…This case report highlights important diagnostic clues in the differential diagnosis of Balo concentric sclerosis. …”
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    Pitfalls in the diagnosis of a tumefactive demyelinating lesion: A case report
  9. 5749
    “…The underlying programming of fetal development was shown to be associated with an increased risk of degenerative diseases in adulthood, including the metabolic syndrome. There are clues that diet-dependent modifications of the metabolism during fetal life can persist until adulthood. …”
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    A High Protein Diet during Pregnancy Affects Hepatic Gene Expression of Energy Sensing Pathways along Ontogenesis in a Porcine Model
  10. 5750
    “…The study provides an opportunity for further understanding of miRNA function in the regulation of flounder metamorphosis and gives us clues for further studies of the mechanisms of metamorphosis in Japanese flounder.…”
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    Identification and Differential Expression of MicroRNAs during Metamorphosis of the Japanese Flounder (Paralichthys olivaceus)
  11. 5751
    “…BACKGROUND: Exploring spatial-temporal patterns of disease incidence through cluster analysis identifies areas of significantly elevated or decreased risk, providing potential clues about disease risk factors. Little is known about the etiology of non-Hodgkin lymphoma (NHL), or the latency period that might be relevant for environmental exposures, and there are no published spatial-temporal cluster studies of NHL. …”
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    Spatial-temporal analysis of non-Hodgkin lymphoma in the NCI-SEER NHL case-control study
  12. 5752
    “…This realization provides important insights into mechanisms that might be employed by real cells migrating in complex environments as well as clues for the design of robotic navigation strategies. …”
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    “Self-Assisted” Amoeboid Navigation in Complex Environments
  13. 5753
    “…Interestingly, now the disease process is trying to unveil itself through various other clues. We present the case of the same diver who later developed a series of other medical problems, along with more than 5 admissions for spontaneous pneumothoraces, all falling into the constellation represented by the Birt-Hogg-Dubé syndrome. …”
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    Birt-Hogg-Dubé Syndrome: Answering Questions Raised by a Case Report Published in 1962
  14. 5754
    “…We studied geographic variation in advertisement calls in the tree frog Hyla japonica to understand patterns of variation in these traits across Korea and provide clues about the underlying forces for variation. …”
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    Geographic Variation in Advertisement Calls in a Tree Frog Species: Gene Flow and Selection Hypotheses
  15. 5755
    “…This work provides important clues to the progression of Parkinson's, and provides a new target for strategies to ameliorate the progression of this disease.…”
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    Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism
  16. 5756
    “…Our study will provide clues to investigate the molecular basis of extended antibiotics resistance of NDM-1 and then accelerate the search for new antibiotics against NDM-1 positive strain in clinical studies.…”
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    Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant
  17. 5757
    “…We hope our paradigm could be a promising method to identify disease gene interaction pathways for other types of complex diseases, affording additional clues in the pathogenesis of complex diseases.…”
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    Disease Gene Interaction Pathways: A Potential Framework for How Disease Genes Associate by Disease-Risk Modules
  18. 5758
    “…When these antibodies do occur, it is important to be able to isolate and characterize them to provide clues for vaccine design. CAP206 is a South African subtype C HIV-1-infected individual previously shown to have broadly neutralizing plasma antibodies targeting the envelope gp41 distal membrane proximal external region (MPER). …”
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    Isolation of a Human Anti-HIV gp41 Membrane Proximal Region Neutralizing Antibody by Antigen-Specific Single B Cell Sorting
  19. 5759
    “…The observation of human MPP8 chromodomain in both solution and crystal lattice may provide clues to study MPP8-mediated gene regulation furthermore.…”
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    Structural Basis for Specific Binding of Human MPP8 Chromodomain to Histone H3 Methylated at Lysine 9
  20. 5760
    “…Further, it will provide new insights into its pathogenicity and clues needed to formulate media to support the in vitro cultivation of M. haemofelis.…”
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    Genome of Mycoplasma haemofelis, unraveling its strategies for survival and persistence
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