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  1. 5781
    “…The regulation of MscL expression displays rich behaviors that depend strongly on culturing conditions and stress factors, which may give clues to the physiological role of MscL. The number of stress-induced MscL channels and the associated variability have far reaching implications for the in vivo response of the channels and for modeling of this response. …”
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    Single-Cell Census of Mechanosensitive Channels in Living Bacteria
  2. 5782
    “…The findings in this study also provide important clues to better understand the complex dynamics of translational process.…”
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    Synonymous Codon Ordering: A Subtle but Prevalent Strategy of Bacteria to Improve Translational Efficiency
  3. 5783
    “…Together, these results provide important clues as to the structure, function and evolution of SRP.…”
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    Identification and comparative analysis of components from the signal recognition particle in protozoa and fungi
  4. 5784
    por Gillis, Jesse, Pavlidis, Paul
    Publicado 2012
    “…We explore a number of consequences of this and find that network structure itself provides clues as to which connections are critical and that systemic properties, such as scale-free-like behaviour, do not map onto the functional connectivity within networks.…”
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    “Guilt by Association” Is the Exception Rather Than the Rule in Gene Networks
  5. 5785
    “…Furthermore, the transcriptional data provided potential clues as to how A. pleuropneumoniae is able to circumvent host immune factors and survive within the hostile environment of host macrophages. …”
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    Transcriptional Portrait of Actinobacillus pleuropneumoniae during Acute Disease - Potential Strategies for Survival and Persistence in the Host
  6. 5786
    “…Exploring the demographic and clinical correlates of trait anhedonia in the general population may provide clues to the pathogenesis of psychotic disorder.…”
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    A Study of Trait Anhedonia in Non-Clinical Chinese Samples: Evidence from the Chapman Scales for Physical and Social Anhedonia
  7. 5787
    “…The monocular trial can give useful clues as to whether a medication is effective, but should not be the only information used in making this determination. …”
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    Comparing the efficacy of the monocular trial treatment paradigm with multiple measurements of intraocular pressure before and after treatment initiation in primary open-angle glaucoma
  8. 5788
    “…An investigation of function and expression patterns of genes identified a number of key candidate genes and pathways in early stages of protoplast reprogramming, which provided important clues to reveal the molecular mechanisms responsible for protoplast reprogramming. …”
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    Transcriptome of Protoplasts Reprogrammed into Stem Cells in Physcomitrella patens
  9. 5789
    por Allard, John B., Duan, Cunming
    Publicado 2011
    “…The exact underlying causes of the aging process remain a topic for debate, and clues that may shed light on these causes are eagerly sought after. …”
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    Comparative Endocrinology of Aging and Longevity Regulation
  10. 5790
    “…C-24 mimics the first four N-terminal residues of the NOP-selective peptide antagonist UFP-101, a close derivative of N/OFQ, and provides important clues to binding of these peptides. The X-ray structure also reveals substantial conformational differences in the pocket regions between NOP and the “classical” opioid receptors κ (Ref. 1) and μ (Ref. 2), which are likely due to a small number of residues that vary between the two receptors. …”
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    Structure of the Nociceptin/Orphanin FQ Receptor in Complex with a Peptide Mimetic
  11. 5791
    “…Our work suggests that both the transcription-independent and -dependent p53 activities are indispensable for a reliable choice of cell fate and also provides clues to therapeutic manipulation of the p53 pathway in cancer treatment.…”
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    A Two-Step Mechanism for Cell Fate Decision by Coordination of Nuclear and Mitochondrial p53 Activities
  12. 5792
    “…It is anticipated that the new method may become a high-throughput tool in annotating protein domains, or may, at the very least, play a complementary role to the existing domain prediction methods, and that the findings about the key features with high impacts to the domain prediction might provide useful insights or clues for further experimental investigations in this area. …”
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    Prediction of Protein Domain with mRMR Feature Selection and Analysis
  13. 5793
    “…CONCLUSIONS: Although we discovered new clues to understanding the evolutionary relationships within the Erinaceidae, our results nonetheless, strongly suggest that more robust analyses employing more complete taxon sampling (to include fossils) and multiple unlinked genes would greatly enhance our understanding of the Erinaceidae. …”
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    An Estimation of Erinaceidae Phylogeny: A Combined Analysis Approach
  14. 5794
    “…Thus, miR-19, CYLD and NF-κB form a regulatory FFL, which provides new clues for sustained activation of NF-κB in T-ALL. …”
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    MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia
  15. 5795
    “…SIGNIFICANCE: Transcriptome profiling of S. japonica provides clues to potential genes identification and future functional genomics study. …”
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    Transcriptome Sequencing and Comparative Analysis of Saccharina japonica (Laminariales, Phaeophyceae) under Blue Light Induction
  16. 5796
    “…Hierarchical clustering of E2-host interaction profiles mostly recapitulated HPV phylogeny and provides clues to the involvement of E2 in HPV infection. …”
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    Large Scale Genotype Comparison of Human Papillomavirus E2-Host Interaction Networks Provides New Insights for E2 Molecular Functions
  17. 5797
    “…In this study, with the aim of revealing the molecular basis for unintended effects of a single site insertion GM Kemingdao (KMD) rice transformed with a synthetic cry1Ab gene, and bridging unintended effects of KMD rice through clues of differentially expressed genes, comparative transcriptome analyses were performed for GM KMD rice and its parent rice of Xiushui11 (XS11). …”
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    Differentially Expressed Genes Distributed Over Chromosomes and Implicated in Certain Biological Processes for Site Insertion Genetically Modified Rice Kemingdao
  18. 5798
    “…The differences in SET gene structure, domain architecture, and expression profiles in various tissues of Populus suggest that members of the SET gene family have a variety of developmental and physiological functions. Our study provides clues about the evolution of epigenetic regulation of chromatin structure and gene expression.…”
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    Expansion and diversification of the SET domain gene family following whole-genome duplications in Populus trichocarpa
  19. 5799
    por Zeng, Tao, Chen, Luonan
    Publicado 2012
    “…However, it is a fundamental but important mission to trace the temporal characteristics of a biological system during a specific phase transition process, which can offer clues for understanding dynamic behaviors of living organisms. …”
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    Tracing dynamic biological processes during phase transition
  20. 5800
    “…CONCLUSIONS: This work provides us some clues for using these properties of complex networks in computational models and to some extent reveals the biological meanings underlying these general network properties.…”
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    Inferring domain-domain interactions from protein-protein interactions in the complex network conformation
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