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  1. 5881
    “…These results provide potential clues to a new understanding of the pharmacologic modes of action of CLB and N-CLB.…”
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    Clobazam and Its Active Metabolite N-desmethylclobazam Display Significantly Greater Affinities for α(2)- versus α(1)-GABA(A)–Receptor Complexes
  2. 5882
    “…These domains serve a range of different functions within the proteins in which they are found, including both catalytic and non-catalytic versions. Clues to the function of protein domains belonging to such a diverse superfamily can be gleaned from analysis of the proteins and organisms in which they are found. …”
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    Filling out the structural map of the NTF2-like superfamily
  3. 5883
    “…Our findings provide new clues into the mechanisms involved in lymphoma progression and may indicate new targets for effective treatment of malignant effusions growing in body cavities.…”
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    Crosstalk between the mesothelium and lymphomatous cells: insight into the mechanisms involved in the progression of body cavity lymphomas
  4. 5884
    “…Suitable mouse models should complement the analysis of human tumor tissues and may provide clues to these questions currently perplexing ovarian cancer biology. …”
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    Development of a Mouse Model of Menopausal Ovarian Cancer
  5. 5885
    “…These findings shed new light on the role individual residues have on stability of the receptor and also provide some clues as to the regions of the protein responsible for constitutive activity. …”
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    Arginine 199 and Leucine 208 Have Key Roles in the Control of Adenosine A(2A) Receptor Signalling Function
  6. 5886
    “…Understanding the interactions between hosts and WSSV at the initial stage of acute infection will not only help to get a deep insight into the pathogenesis of WSSV but also provide clues for therapies.…”
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    Transcriptome Analysis of the Initial Stage of Acute WSSV Infection Caused by Temperature Change
  7. 5887
    “…This report provides mechanistic clues into ERG-driven drug resistance in the poor prognostic group of high ERG expressers, provides insight to improved drug targeted therapies, and provides novel markers for a mesenchymal-like state in acute leukemia.…”
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    ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells
  8. 5888
    “…Identification of protein substrates of caspase-2 that are efficiently cleaved within cells may also provide clues to the role of this protease. We used a yeast-based transcriptional reporter system to define the minimal substrate specificity of caspase-2. …”
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    Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate
  9. 5889
    “…Bacterial metabolic pathways often are encoded by “genome neighborhoods” (gene clusters and/or operons), which can provide important clues for functional assignment. We recently demonstrated the synergy of docking and pathway context by “predicting” the intermediates in the glycolytic pathway in E. coli(5). …”
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    Discovery of new enzymes and metabolic pathways using structure and genome context
  10. 5890
    “…The examination of differences in gene expression profiling between uninfected and O. viverrini-infected B. siamensis goniomphalos could provide clues on fundamental pathways involved in the regulation of snail-parasite interplay. …”
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    RNA-Seq Reveals Infection-Induced Gene Expression Changes in the Snail Intermediate Host of the Carcinogenic Liver Fluke, Opisthorchis viverrini
  11. 5891
    “…Delineating the underlying mechanism(s) for these differences will not only aid in improving vaccine-mediated protection but possibly also provide clues for the susceptibility to infection in different regions of the world.…”
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    Pattern recognition receptor-mediated cytokine response in infants across 4 continents(⋆)()
  12. 5892
    “…These findings suggest, for the first time, that the regulation of complex I subunit expression in FRDA is complex, rather than merely being a reflection of global co-regulation, and may provide important clues toward novel therapeutic strategies for FRDA and mitochondrial complex I deficiency.…”
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    Gene Expression Profiling of Mitochondrial Oxidative Phosphorylation (OXPHOS) Complex I in Friedreich Ataxia (FRDA) Patients
  13. 5893
    “…This report may provide important clues regarding the management of this rare anomaly and we emphasise the importance for paediatricians, who should consider the possibility that a fever of unknown origin can be caused by an urachal cyst, and for surgeons and urologists, because it suggests that conservative treatment of this rare anomaly should be considered when possible.…”
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    Clinical considerations, management and treatment of fever of unknown origin caused by urachal cyst: a case report
  14. 5894
    “…Phylogenetic and distributional patterns of Tylos provide important clues on the biogeography and evolution of this group. …”
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    Global Diversification at the Harsh Sea-Land Interface: Mitochondrial Phylogeny of the Supralittoral Isopod Genus Tylos (Tylidae, Oniscidea)
  15. 5895
    “…BACKGROUND: Few clues were found in the literature about the independent risk factors for PTSD among earthquake survivors in Sichuan province three years after the 2008 earthquake. …”
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    Risk Factors of Post-Traumatic Stress Disorder (PTSD) after Wenchuan Earthquake: A Case Control Study
  16. 5896
    por Chanzu, Nadia, Ondondo, Beatrice
    Publicado 2014
    “…Some of these responses strongly correlate with protection from HIV acquisition and/or disease progression, thus providing significant clues of the ideal components of an efficacious HIV vaccine. …”
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    Induction of Potent and Long-Lived Antibody and Cellular Immune Responses in the Genitorectal Mucosa Could be the Critical Determinant of HIV Vaccine Efficacy
  17. 5897
    “…The new information reviewed here provides clues into the unexpectedly complex roles of these transporters, including a proposed indirect regulation of the stress response machinery and control of membrane potential and/or internal pH, with a special emphasis on a genome-wide view of the regulation and evolution of MDR/MXR-MFS transporters.…”
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    MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches
  18. 5898
    “…They underscore the new role of USF1 and give new clues of how p53 loss of function can occur in any cell type. …”
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    p53 Requires the Stress Sensor USF1 to Direct Appropriate Cell Fate Decision
  19. 5899
    “…BACKGROUND: Radiographic findings may provide clues to the underlying cause of neck symptoms. However, these associations remain controversial. …”
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    Association between roentgenographic findings of the cervical spine and neck symptoms in a Japanese community population
  20. 5900
    “…BACKGROUND: The presence of “mechanic’s hands” is one of the clinical clues for collagen vascular diseases. However, the exact relevance of “mechanic’s hands” in collagen vascular diseases has not been well documented. …”
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    Mechanic’s hands revisited: is this sign still useful for diagnosis in patients with lung involvement of collagen vascular diseases?
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