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  1. 6021
    “…Examples include mutation profiles giving clues about aetiology and biomarkers for early detection, to stratify individuals for screening or for prognosis. …”
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    Cancer prevention as part of precision medicine: ‘plenty to be done’
  2. 6022
    “…The scrapes most probably occur near nesting colonies, as yet unknown or no longer preserved in the immediate study areas. Thus, they provide clues to paleoenvironments where such nesting sites occurred.…”
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    Theropod courtship: large scale physical evidence of display arenas and avian-like scrape ceremony behaviour by Cretaceous dinosaurs
  3. 6023
    “…One may find important clues in the clinical history (e.g., age at disease onset, detailed seizure description and past history) to make a correct diagnosis.…”
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    Comparison of temporal lobe epilepsy with hippocampal sclerosis and temporal lobe epilepsies due to other etiologies
  4. 6024
    por Frank, Steven A
    Publicado 2004
    “…The different causes of death show distinct mortality patterns, providing some clues about the varying acceleration of mortality at different ages. …”
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    A multistage theory of age-specific acceleration in human mortality
  5. 6025
    “…Such gender effects provide important clues into the social aetiology of youth injury.…”
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    Relationships between community social capital and injury in Canadian adolescents: a multilevel analysis
  6. 6026
    “…CONCLUSIONS: This is a rare case report of Weston Hurst syndrome having both initial brain biopsy on day 2 and full autopsy results on day 5 of presentation revealing important clinical clues about the pathogenesis of this often fatal disorder.…”
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    Mycoplasma pneumoniae, a trigger for Weston Hurst syndrome
  7. 6027
    “…Further study on rhythm effect may provide clues to understand the common basis over animals from rats to humans.…”
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    Mozart, Mozart Rhythm and Retrograde Mozart Effects: Evidences from Behaviours and Neurobiology Bases
  8. 6028
    “…In conclusion, this study provides some clues of the association of cisplatin resistance with HER2 upregulation-induced EMT in gastric cancer cells.…”
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    Cisplatin resistance in gastric cancer cells is associated with HER2 upregulation-induced epithelial-mesenchymal transition
  9. 6029
    por Whiston, Emily, Taylor, John W.
    Publicado 2015
    “…Phylogenomic detection of gene family expansion and contraction can provide clues to fungal function but is sensitive to taxon sampling. …”
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    Comparative Phylogenomics of Pathogenic and Nonpathogenic Species
  10. 6030
    “…Overall, we have described the deleterious effects of preeclampsia on the brains of offspring, providing clues to the cellular and molecular mechanisms involved in this pathogenesis, which may aid in the development of therapeutic approaches. …”
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    Developmental and Functional Brain Impairment in Offspring from Preeclampsia-Like Rats
  11. 6031
    “…BATMAN-TCM will contribute to the understanding of the “multi-component, multi-target and multi-pathway” combinational therapeutic mechanism of TCM, and provide valuable clues for subsequent experimental validation, accelerating the elucidation of TCM’s molecular mechanism. …”
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    BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine
  12. 6032
    “…Furthermore, our data establish a model for E2-induced apoptosis in HR-HPV types and provide important clues for designing E2 analogs that might modulate procaspase-8 activation and hence apoptosis.…”
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    Insights into the mechanism of human papillomavirus E2-induced procaspase-8 activation and cell death
  13. 6033
    “…Moreover, the information generated by our group helps in a better understanding of the biology of freshwater cartilaginous fishes and offers clues for the development of clinical treatments for stingray envenoming in Brazil and around the world. …”
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    Venom gland transcriptome analyses of two freshwater stingrays (Myliobatiformes: Potamotrygonidae) from Brazil
  14. 6034
    por Kang, Mingon, Tang, Liping, Gao, Jean
    Publicado 2016
    “…CONCLUSIONS: The computational modeling not only provides critical clues to recognize current knowledge of fibrosis development but also enables the prediction of yet-to-be observed biological phenomena. …”
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    Computational modeling of phagocyte transmigration for foreign body responses to subcutaneous biomaterial implants in mice
  15. 6035
    “…In a bioreactor, these samples were stimulated by interleukin 1β (Il1ß) (2 ng/ml) plus mechanical load (2.0 Mpa at 0.5 Hz horizontal and 0.1 Hz vertical rotation), thus the experimental setup recapitulated both catabolic and anabolic clues of the OA joint. RESULTS: Upon addition of HA at either 1 or 3 mg/ml, we observed a significant suppression of expression of metalloproteinase (MMP)-13. …”
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    Hyaluronic Acid Suppresses the Expression of Metalloproteinases in Osteoarthritic Cartilage Stimulated Simultaneously by Interleukin 1β and Mechanical Load
  16. 6036
    “…Our findings not only provide an explanation for the “peaceful” coexistence of ligand and receptor of a representative member of the TNF superfamily but give us vital clues for the design of activity-enhanced TR3-based cancer therapeutics.…”
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    Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology
  17. 6037
    “…Genes involved in secondary metabolism were most highly expressed during growth on insect tissue, suggesting that their products may not be necessary during parasitism of Elaphomyces. This study provides clues into understanding genetic mechanisms underlying the transition from insect to truffle parasitism.…”
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    Differential Expression of Genes Involved in Host Recognition, Attachment, and Degradation in the Mycoparasite Tolypocladium ophioglossoides
  18. 6038
    “…Our study precisely defined the genetic features of modern Beijing strains and provided interesting clues for future researches to elucidate the mechanisms that underlie this sublineage's successful expansion. …”
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    Genetic features of Mycobacterium tuberculosis modern Beijing sublineage
  19. 6039
    por Ye, Eun-Ah, Steinle, Jena J.
    Publicado 2016
    “…Our study will contribute to understanding of diabetic retinal pathology, as well as providing important clues to develop therapeutics for clinical applications.…”
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    miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNFα to Protect Primary Human Retinal Microvascular Endothelial Cells Grown in High Glucose
  20. 6040
    “…Our study sheds new insights on the molecular mechanisms governing the resistance to TRAIL in tumor cells, and provides new clues for the combinatorial chemotherapeutic interventions with TRAIL.…”
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    hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells
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