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  1. 6041
    “…Our study provided potential biomarkers and clues for further research of biomarkers for therapeutic responses and ADRs in Chinese NSCLC patients.…”
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    Genetic Association of Curative and Adverse Reactions to Tyrosine Kinase Inhibitors in Chinese advanced Non-Small Cell Lung Cancer patients
  2. 6042
    por Maestri, Renan, Patterson, Bruce D.
    Publicado 2016
    “…Understanding the spatial distribution of species sheds light on the group’s biogeographical history, offers clues to the drivers of diversity, and helps to guide conservation strategies. …”
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    Patterns of Species Richness and Turnover for the South American Rodent Fauna
  3. 6043
    “…Because PRRT2 plays a role at the synapse, it is important to confirm the exact orientation of its N and C termini with respect to the plasma membrane to get clues regarding its possible function. Using a combination of different experimental approaches, including live immunolabeling, immunogold electron microscopy, surface biotinylation and computational modeling, we demonstrate a novel topology for this protein. …”
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    A Novel Topology of Proline-rich Transmembrane Protein 2 (PRRT2): HINTS FOR AN INTRACELLULAR FUNCTION AT THE SYNAPSE
  4. 6044
    por Jordan, I. King
    Publicado 2016
    “…Investigation of such ancestry-enriched genomic regions can be used to provide clues as to the functional roles of the genes therein and the selective forces that have acted to increase their frequency in the population. …”
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    The Columbian Exchange as a source of adaptive introgression in human populations
  5. 6045
    por Costa, Daniel, Castelo, Robert
    Publicado 2016
    “…CONCLUSION: The FIR expression signature in UC tissue contains molecular clues about signaling pathways that trigger FIR, and it is consistent with an acute inflammatory response by fetal innate and adaptive immune systems, which participate in the pathogenesis of neonatal brain damage.…”
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    Umbilical cord gene expression reveals the molecular architecture of the fetal inflammatory response in extremely preterm newborns
  6. 6046
    “…This finding may provide pathophysiological clues about the development of infertility.…”
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    Systematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility
  7. 6047
    “…Our study further supports the role of mutations in the SLCO2A1 gene in the pathogenesis of PDP and could provide additional clues to the genotype-phenotype relations of PDP.…”
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    Identification of the Mutations in the Prostaglandin Transporter Gene, SLCO2A1 and Clinical Characterization in Korean Patients with Pachydermoperiostosis
  8. 6048
    “…Better understanding of racial and geographic disparities in the diffusion of heart disease prevention and treatment may allow us to find clues to progress toward racial and geographic equity in heart disease mortality.…”
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    Disparities in Temporal and Geographic Patterns of Declining Heart Disease Mortality by Race and Sex in the United States, 1973–2010
  9. 6049
    “…This study provides unique insights into the mode of action of roneparstat as well as clues of its interaction with heparanase at a molecular level, which could be exploited to design novel potential inhibitor molecules.…”
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    Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase
  10. 6050
    “…Our pioneering study uncovers a role of R-spondin1 in the activation of cultured hair follicle stem cells and the regulation of hair cycle progression, shedding new light on the governance of Wnt/β-catenin signaling in skin biology and providing helpful clues for future treatment of hair follicle disorders.…”
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    Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles
  11. 6051
    “…Our data reveal a major role for MMP11 in controlling energy metabolism, and provide new clues for understanding the relationship between metabolism, cancer progression and patient outcome.…”
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    Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch
  12. 6052
    por Ruslai, Nurul Hidayati, Salam, Abdus
    Publicado 2016
    “…Triggers should have planned clues that lead students to generate issues correlate with faculty objectives. …”
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    PBL triggers in relation to students’ generated learning issues and predetermined faculty objectives: Study in a Malaysian public university
  13. 6053
    por Wu, XianMing, Hurst, Laurence D.
    Publicado 2016
    “…Where in genes do pathogenic mutations tend to occur and does this provide clues as to the possible underlying mechanisms by which single nucleotide polymorphisms (SNPs) cause disease? …”
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    Determinants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs
  14. 6054
    “…Altogether, our results provide new clues for understanding the mechanism behind the ZBD-independent inactivation of BLM by Cd(2+) leading to accumulation of DNA double-strand breaks.…”
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    Mechanistic insight into cadmium-induced inactivation of the Bloom protein
  15. 6055
    “…These findings raise the possibility that the biological effects of CLU may be relatively confined to neuroimaging trait and hence may offer clues to AD.…”
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    Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts
  16. 6056
    “…As such, the analysis of mutations in the genes encoding GPCRs, G-proteins and their downstream targets provides important clues regarding how these signaling cascades contribute to malignancy. …”
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    Inactivating Mutations in GNA13 and RHOA in Burkitt’s Lymphoma and Diffuse Large B cell Lymphoma: A Tumor Suppressor Function for the Gα(13)/RhoA Axis in B Cells
  17. 6057
    “…This study provides valuable clues to better understand the biosynthesis, excretion and regulation of PCN in Pseudomonas and also provides potential gene targets for further engineering high-yield strains.…”
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    iTRAQ-based quantitative proteomic analysis reveals potential factors associated with the enhancement of phenazine-1-carboxamide production in Pseudomonas chlororaphis P3
  18. 6058
    “…These data demonstrate that LipL32 contributes to the renal pathology in leptospirosis and gives some clues to the potential virulence of LipL32. Our results support the use of zebrafish as a model organism for studying the disease mechanism of leptospiral infection. …”
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    Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae
  19. 6059
    “…These findings provide new clues to the pathogenesis of PD and related disorders that can lead to novel treatments of these disorders. …”
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    Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons
  20. 6060
    “…Given the difficulty in biopsying the pituitary, careful attention must be paid to the systemic clinical presentation to provide clues as to the underlying disorder.…”
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    IgG4-related hypophysitis presenting as diabetes insipidus with tubulo-interstital nephritis and mediastinal lymphadenopathy
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