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  1. 6061
    “…The cellular responses that occur in muscle fibres following exercise provide valuable clues to the molecular mechanisms regulating muscle homoeostasis and potentially the progression of sarcopenia. …”
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    Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression
  2. 6062
    “…These findings will offer new clues for OS development and progression and offer SB as a potent targeted agent for OS treatment.…”
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    Histone deacetylase inhibitor sodium butyrate suppresses proliferation and promotes apoptosis in osteosarcoma cells by regulation of the MDM2–p53 signaling
  3. 6063
    por Yu, Lei, Hou, Ping, Liu, Guo-Ping, Zhang, Hong
    Publicado 2016
    “…The current study provides valuable clues regarding the SLC5A2 molecule from genotype to phenotype in families affected by FRG.…”
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    Novel SLC5A2 mutation contributes to familial renal glucosuria: Abnormal expression in renal tissues
  4. 6064
    “…However, most genome-wide association studies did not provide clues about the contribution of DNA variations to impaired drug responsiveness. …”
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    Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes
  5. 6065
    “…Identification of proteins like PII-like protein, cyclophilin, elongation factor-TU, oxygen-evolving enhancer protein and rubisco activase offers a peculiar overview of changes elicited by elevated [CO(2)], providing clues about how N-efficient cultivar of Indian mustard adapt to low N supply under elevated [CO(2)] conditions. …”
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    Nitrogen-Efficient and Nitrogen-Inefficient Indian Mustard Showed Differential Expression Pattern of Proteins in Response to Elevated CO(2) and Low Nitrogen
  6. 6066
    por Chen, Pei, Li, Yongjun
    Publicado 2016
    “…BACKGROUND: Unlike traditional detection of a disease state in which there are clear phenomena, it is usually a challenge to identify the pre-disease state during the progression of a complex disease just before the serious deterioration, not only because of the high complexity of the biological system, but there may be few clues and apparent changes appearing until the catastrophic critical transition occurs. …”
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    The decrease of consistence probability: at the crossroad of catastrophic transition of a biological system
  7. 6067
    por Blaess, M, Le, HP, Claus, RA, Kohl, M, Deigner, H-P
    Publicado 2015
    “…Enantioselective effects on transcription induced by metabolically stable synthetic probes provide clues on molecular mechanisms of ceramide-induced signaling, as well as leads for future anti-cancer agents.…”
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    Stereospecific induction of apoptosis in tumor cells via endogenous C(16)-ceramide and distinct transcripts
  8. 6068
    “…Our results show that the combination of newly developed computational programs can be successfully utilized for the discovery of novel sRNAs and indicate an intricate system of gene regulation through sRNAs in A. pleuropneumoniae and in other Pasteurellaceae, thus providing clues for novel aspects of virulence that will be explored in further studies.…”
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    A computational strategy for the search of regulatory small RNAs in Actinobacillus pleuropneumoniae
  9. 6069
    “…Collectively, these results suggest that the PROFILER technology can rapidly and reliably identify, in the context of complex conformational epitopes, discrete “hot spots” with a crucial role in antigen-antibody interactions, thereby providing useful clues for the functional characterization of the epitope.…”
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    Functional characterization of a monoclonal antibody epitope using a lambda phage display-deep sequencing platform
  10. 6070
    “…Altogether, these results provided important clues regarding the evolution of symbiotic genes in a Nod factor-independent context. …”
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    A gene-based map of the Nod factor-independent Aeschynomene evenia sheds new light on the evolution of nodulation and legume genomes
  11. 6071
    “…We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. …”
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    Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects
  12. 6072
    “…Here, we report a systematic study on the secretory proteins (secretome) and secretory N-glycoproteins (N-glycosecretome) of four human hepatocellular carcinoma (HCC) cell lines with different metastatic potential, to explore the molecular mechanism of metastasis and supply the clues for effective measurement of diagnosis and therapy. …”
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    In-depth analysis of secretome and N-glycosecretome of human hepatocellular carcinoma metastatic cell lines shed light on metastasis correlated proteins
  13. 6073
    “…Altogether, the study provides novel clues on the role of HSPs in conferring stress tolerance.…”
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    Genome-wide analysis of heat shock proteins in C(4) model, foxtail millet identifies potential candidates for crop improvement under abiotic stress
  14. 6074
    “…Transplantation successfully bridged the animals through the critical period for survival after acute liver failure, providing promising clues of integration and full in vivo functionality of these cells after treatment with WIF-1 and DKK-1.…”
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    Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/β-catenin Pathway Inhibition
  15. 6075
    “…The finding of asymmetrical hexameric organization is supported by structural evidence of many other ATPase systems showing the presence of one noncovalent dimer and four monomer subunits. All of these provide clues for why the asymmetrical hexameric ATPase gp16 of ϕ29 was previously reported as a pentameric configuration by cryo-electron microscopy (cryo-EM) since the contact by the arginine finger renders two adjacent ATPase subunits closer than other subunits. …”
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    An Arginine Finger Regulates the Sequential Action of Asymmetrical Hexameric ATPase in the Double-Stranded DNA Translocation Motor
  16. 6076
    “…Leishmaniasis has a wide spectrum of signs and symptoms due to infection to numbers of Leishmania species and makes enormous mortality and morbidity. There are clues of antileishmanial effects of prenylated coumarins. …”
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    Antileishmanial activity of prenylated coumarins isolated from Ferulago angulata and Prangos asperula
  17. 6077
    “…The reliability of the RNA-Seq data was confirmed by qPCR analysis. Our findings provide clues to build a link between CD36, host metabolism and the HBV life cycle and identified areas that require further investigation.…”
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    Genome-Wide Transcriptome Analysis of CD36 Overexpression in HepG2.2.15 Cells to Explore Its Regulatory Role in Metabolism and the Hepatitis B Virus Life Cycle
  18. 6078
    “…We examined the transcription patterns of the FT/TFL1 genes during the vegetative growth and floral transition in C. rubrum to get clues about their possible functions. All the genes except for the constitutively expressed CrFTL2 gene, and the CrFTL3 gene, which was transcribed only in seeds, exhibited organ-specific expression influenced by the specific light regime. …”
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    The Evolution of the FT/TFL1 Genes in Amaranthaceae and Their Expression Patterns in the Course of Vegetative Growth and Flowering in Chenopodium rubrum
  19. 6079
    “…Identifying the relative contributions of these neural pathways in PD patients with overlapping motor and mood symptoms could provide new pathophysiological clues for the development of better therapeutic targets for affected patients.…”
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    Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies
  20. 6080
    por Trovato, Guglielmo M
    Publicado 2016
    “…The filter and integration of ecg and echocardiographic information, addressing to the clues of right ventricular impairment, pulmonary embolism and pulmonary hypertension, and other less frequent conditions, such as congenital, inherited and systemic disease, usually allow more timely diagnosis and therapeutic choice. …”
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    Thoracic ultrasound: A complementary diagnostic tool in cardiology
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