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  1. 6621
    “…In addition, the potential of miR-223-3p as therapeutic target and biomarker for diagnosis and prediction of cardiovascular diseases will be further discussed, providing clues for clinicians.…”
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    MiR-223-3p in Cardiovascular Diseases: A Biomarker and Potential Therapeutic Target
  2. 6622
    “…The study provides new clues for further understanding the mechanism of DBS and for advancing the clinical application of DBS in treating epilepsy.…”
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    Suppressing synchronous firing of epileptiform activity by high‐frequency stimulation of afferent fibers in rat hippocampus
  3. 6623
    por Efrat, Shimon
    Publicado 2021
    “…These studies provide evidence for reproducible epigenetic memory in BiPSCs. Bi-DOCs may provide clues to genes and pathways involved in the differentiation process, which could be manipulated to increase the efficiency and reproducibility of differentiation of pluripotent stem cells from non-β-cell sources.…”
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    Epigenetic Memory: Lessons From iPS Cells Derived From Human β Cells
  4. 6624
    “…CONCLUSION: FM-associated dermoscopic patterns and distal diffuse and linear patterns could be helpful diagnostic clues for differential diagnosis of FM from subungual melanoma.…”
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    Clinical and Dermoscopic Features of Fungal Melanonychia: Differentiating from Subungual Melanoma
  5. 6625
    “…Our study implies the shift of dominant antigens at different infection statuses, providing the clues for the selection of mycobacterial antigens in vaccine development and precision revaccination in the future.…”
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    Age-Related Immunoreactivity Profiles to Diverse Mycobacterial Antigens in BCG-Vaccinated Chinese Population
  6. 6626
    “…A better understanding of the localization patterns of gliomas could provide clues to the origins of these types of tumours, and consequently inform treatment targets. …”
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    Genetic, cellular, and connectomic characterization of the brain regions commonly plagued by glioma
  7. 6627
    “…The study not only provided foundations for molecular breeding, somaclonal variation breeding, preservation and propagation of elite germplasm, but also offered clues for further revealing novel mechanisms of both stem-explant dedifferentiation and MSV of L. ruthenicum.…”
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    A novel micropropagation of Lycium ruthenicum and epigenetic fidelity assessment of three types of micropropagated plants in vitro and ex vitro
  8. 6628
    “…These findings may provide further clues to elucidate the mechanisms of neurological side effects, especially the brain cognitive function impairment, caused by long-term usage of BBB-permeable statins.…”
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    Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice
  9. 6629
    “…CONCLUSION: In conclusion, this cross-disease strategy provided important clues to explain lower IQ scores and dysregulated COMT expression among three common mental illnesses.…”
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    Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression
  10. 6630
    “…The reported molecular construct serves as an intermediary case between a fully conjugated donor-acceptor system and a donor/acceptor binary mix, which may provide important clues on the design and control of high-freedom molecular systems with complex excited-state dynamics.…”
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    Thermochromic aggregation-induced dual phosphorescence via temperature-dependent sp(3)-linked donor-acceptor electronic coupling
  11. 6631
    “…However, recent advances in both neuropathological and cellular studies have provided us with clues enabling us to better understand the effect of individual DPRs on disease pathogenesis. …”
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    Emerging Perspectives on Dipeptide Repeat Proteins in C9ORF72 ALS/FTD
  12. 6632
    “…It provides interesting fundamental clues to CRKL‐related carcinogenesis through glucose metabolism and offers novel therapeutic strategies for hepatocarcinoma.…”
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    CRKL promotes hepatocarcinoma through enhancing glucose metabolism of cancer cells via activating PI3K/Akt
  13. 6633
    “…Taken together, our results reveal a fast mechanism of activated T cell inhibition by MSCs, which provides new clues to unravel the MSC-mediated immunoregulatory mechanism for aGVHD and other severe acute T cell-related diseases.…”
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    Mesenchymal Stromal Cells Rapidly Suppress TCR Signaling-Mediated Cytokine Transcription in Activated T Cells Through the ICAM-1/CD43 Interaction
  14. 6634
    “…Furthermore, cfDNA from CSF can interrogate for tumor-associated molecular clues. MB-associated alterations from CSF, tumor, and post-chemotherapy plasma were compared by deep sequencing on next-generation sequencing platform. …”
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    Exploring genetic alterations in circulating tumor DNA from cerebrospinal fluid of pediatric medulloblastoma
  15. 6635
    “…CONCLUSION: ANAs with a nucleolar pattern are a significant predictor of poor prognosis, providing clues for prognostic assessment in patients with leukemia.…”
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    Antinuclear Antibodies With a Nucleolar Pattern Are Associated With a Significant Reduction in the Overall Survival of Patients With Leukemia: A Retrospective Cohort Study
  16. 6636
    “…Our findings enrich fundamental knowledge in the field of gene expression and its regulation, and provide new clues for future studies. One important clue is that nsp15 may be an important and ideal target for the development of drugs (e.g., uridine derivatives) against CoVs.…”
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    A Negative Feedback Model to Explain Regulation of SARS-CoV-2 Replication and Transcription
  17. 6637
    por Ham, In-Hye, Lee, Dagyeong, Hur, Hoon
    Publicado 2021
    “…Recent advancements in single-cell “omics” technologies could offer clues for revealing the specific subtypes and biomarkers related to resistance.…”
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    Cancer-Associated Fibroblast-Induced Resistance to Chemotherapy and Radiotherapy in Gastrointestinal Cancers
  18. 6638
    “…These data indicate dynamic gene expression responses of CSPs and OBPs to fungal infection that provide clues to mechanisms that might mediate detection of microbial pathogens, triggering grooming, and nest sanitation.…”
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    Altered Expression of Chemosensory and Odorant Binding Proteins in Response to Fungal Infection in the Red Imported Fire Ant, Solenopsis invicta
  19. 6639
    por Abarca, Dolores
    Publicado 2021
    “…Molecular knobs connecting the balance cell proliferation/differentiation to hormone signaling pathways, transcriptional control of cell fate or metabolic modulation of developmental programs can offer clues to unveil new elements in the dynamics of adventitious rooting regulatory networks. …”
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    Identifying Molecular Chechkpoints for Adventitious Root Induction: Are We Ready to Fill the Gaps?
  20. 6640
    “…Taken together, this study not only indicates the clinical significance of HSPA5 in COVID-19 disease and cancers, but also provides potential clues for further medical treatments and managements of COVID-19 patients.…”
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    Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19
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