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6681“…FinP and RepX are strikingly similar in length and structure, but not in primary sequence, and so may provide clues to understanding the high selectivity of FinO-RNA interactions. …”
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6682por Al-beitawi, Soha Nafez, Al-Shatanawi, Tariq N., Qudsieh, Suhair Adel, Abu Marar, Ehab Ibrahim, Al Zoubi, Mazhar Salim, Al-zubi, Mohammad“…Determining the preferred specialty and understanding the compulsion affecting specialty choice will provide clues to influence such choice in the future to shift the balance of specialties among practitioners. …”
Publicado 2021
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6683por Silva, Hugo, Anjo, Sandra I., Manadas, Bruno, Abrantes, Isabel, Fonseca, Luís, Cardoso, Joana M. S.“…The differences detected in the secretomes highlighted the diverse responses from the nematode to overcome host defenses with different susceptibilities and provide new clues on the mechanism behind the pathogenicity of this plant-parasitic nematode. …”
Publicado 2021
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6684por Osugi, Tomohiro, Miyasaka, Natsuko, Shiraishi, Akira, Matsubara, Shin, Satake, Honoo“…The phylogenetic position of ascidians as the closest living relatives of vertebrates suggests that cionin can provide clues to the evolution of endocrine/neuroendocrine systems throughout chordates. …”
Publicado 2021
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6685“…Our work provides transcriptomics clues for exploring the influence of NPFF on the physiological functions of BMDMs.…”
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6686por Tian, Yu, Sun, Kai-yi, Meng, Tian-qing, Ye, Zhen, Guo, Shi-meng, Li, Zhi-ming, Xiong, Cheng-liang, Yin, Ying, Li, Hong-gang, Zhou, Li-quan“…The above findings provide preliminary clues supporting that the imbalanced gut microbiota may not be fully restored in recovered patients, highlighting the importance of continuous monitoring of gut health in people who have recovered from COVID-19.…”
Publicado 2021
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6687por Oliveira, Sara R., Dionísio, Pedro A., Gaspar, Maria M., Ferreira, Maria B. T., Rodrigues, Catarina A. B., Pereira, Rita G., Estevão, Mónica S., Perry, Maria J., Moreira, Rui, Afonso, Carlos A. M., Amaral, Joana D., Rodrigues, Cecília M. P.“…It is also usually dependent on RIP1 kinase activity, influenced by further cellular clues. Importantly, necroptosis appears to be strongly linked to several neurodegenerative diseases, including PD. …”
Publicado 2021
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6688por Xu, Haiwei, Li, Yongjin, Li, Jianhua, Huo, Zhenxin, Li, Guowang, Du, Lilong, Tian, Lijun, Xu, Baoshan“…CONCLUSION: This will provide novel clues for future experimental studies to elucidate the pathomechanism of CEPD and therapeutic targets for CEPD-related diseases.…”
Publicado 2021
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6689por Li, Dong-Yang, Yang, Fei, Liao, Wei-Qiang, Zhou, Xiang-Fu, Li, Wen-Biao, Cai, Jia-Rong, Liu, Bo-Long, Luo, Yun, Zhan, Hai-Lun“…CONCLUSION: Deep genomic sequencing of BUC can provide new clues on the unique GAs of Chinese patients and assist in therapeutic decision.…”
Publicado 2021
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6690“…This exceedingly rare presentation of extrauterine ectopic pregnancy offered few clinical clues other than worsening anemia until imaging later revealed the abnormality. …”
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6691“…These specific patterns can be diagnostic clues to distinguish them from other syndromes, such as craniofacial defects, and to remind ophthalmologists that such patients require additional dermatological and neurological examinations and referral. …”
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6692por Zhan, Juan, Sun, Shenghua, Chen, Yixing, Xu, Chaoqun, Chen, Qinwei, Li, Minjie, Pei, Yihua, Li, Qiyuan“…Our findings provide important clues for the pathogenic mechanism of 2q33 in lung carcinogenesis which informs clinical diagnosis and prognosis of LUAD. …”
Publicado 2021
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6693por Zhang, Zeng, Zhu, Kechao, Dai, Huiyong, Wang, Qi, Zhang, Changqing, Zhang, Zhenlin“…Therefore, our findings provide significant clues to the phenotype–genotype relationships in familial ANFH and may be helpful in clinical diagnosis. …”
Publicado 2021
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6694“…Our findings may explicate the pathogenesis of B-ALL, and the disease-associated genes could provide clues to find novel biomarkers for prognosis.…”
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6695Lung Cancer Cell-Derived Exosomal let-7d-5p Down-Regulates OPRM1 to Promote Cancer-Induced Bone Pain“…Our findings clarify the molecular mechanism of CIBP caused by the inhibition of OPRM1 by EXO let-7d-5p, providing new clues and intervention targets for the prevention and treatment of CIBP.…”
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6696por Eto, Futoshi, Koge, Junpei, Tanaka, Kanta, Yoshimoto, Takeshi, Shiozawa, Masayuki, Hatakeyama, Kinta, Toyoda, Kazunori, Koga, Masatoshi“…Conclusions: Atherosclerotic components in retrieved thrombi might provide useful clues for diagnosing stroke pathogenesis. Further studies are warranted to clarify the utility of assessing atheromatous components in retrieved thrombi in diagnosing stroke etiology.…”
Publicado 2021
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6697por Shchukarev, Andrey, Backman, Emelie, Watts, Samuel, Salentinig, Stefan, Urban, Constantin F., Ramstedt, Madeleine“…An understanding of the overall chemical composition of these surface layers may give clues on how these interactions occur and suggest mechanisms to manipulate them. …”
Publicado 2021
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6698por Wang, Zupeng, Liu, Xiaoying, Xie, Xiaodong, Deng, Lei, Zheng, Hao, Pan, Hui, Li, Dawei, Li, Li, Zhong, Caihong“…Our results showed that ABE8e with PTG structure was more suitable for A-to-G conversion in N. benthamiana and provided valuable clues for optimizing ABE tools in other plants.…”
Publicado 2021
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6699por Mulliri, Simone, Laaksonen, Aatto, Spanu, Pietro, Farris, Riccardo, Farci, Matteo, Mingoia, Francesco, Roviello, Giovanni N., Mocci, Francesca“…However, both stabilizing and destabilizing ligands showed similar scores, whilst Molecular Dynamics (MD) simulations, performed across a wide range of temperatures on the GQ in water solution, either unliganded or complexed with two model PBT ligands with the opposite effect on the T(m)s, consistently confirmed their stabilizing or destabilizing ability ascertained by CD. Clues about a relation between the reported anticancer activity of some PBTs and their ability to stabilize the GQ structure of c-myc emerged from our study. …”
Publicado 2021
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6700por Strafella, Claudia, Caputo, Valerio, Termine, Andrea, Fabrizio, Carlo, Ruffo, Paola, Potenza, Saverio, Cusumano, Andrea, Ricci, Federico, Caltagirone, Carlo, Giardina, Emiliano, Cascella, Raffaella“…The present work explored the existence of genetic determinants associated with AMD, which may provide insightful clues concerning its relationship with NDDs and their possible application into the clinical practice. …”
Publicado 2021
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