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  1. 7421
    “…We also calculated the change in dissociation constant (K(d), measure of affinity) each of these mutations introduces into the keratin protein, and present the first model of a keratin dimer L12 region with in silico clues to how the K18 S230T mutation may affect keratin function. …”
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    Intestinal Cell Barrier Function In Vitro Is Severely Compromised by Keratin 8 and 18 Mutations Identified in Patients with Inflammatory Bowel Disease
  2. 7422
    “…Overall, the patterns we documented here challenge the general view of reduced genetic diversity at the edge of a species' range distribution and provide clues for understanding how life-history and major geographic features interact to shape the distribution of genetic diversity.…”
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    Spatial genetic structure in Beta vulgaris subsp. maritima and Beta macrocarpa reveals the effect of contrasting mating system, influence of marine currents, and footprints of postglacial recolonization routes
  3. 7423
    “…Our findings provide significant clues to the phenotype–genotype relationships in these syndromes and may be helpful in clinical diagnosis. …”
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    A Novel p. Gly630Ser Mutation of COL2A1 in a Chinese Family with Presentations of Legg–Calvé–Perthes Disease or Avascular Necrosis of the Femoral Head
  4. 7424
    “…It is able to provide useful clues for novel cell-specific transcriptional regulations. …”
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    REGNET: mining context-specific human transcription networks using composite genomic information
  5. 7425
    “…It is therefore conceivable that this protein may interact with various partners or form multimeric complexes with other proteins to play multiple roles in cells, providing clues to understanding the functions of dOSCP1 during Drosophila development.…”
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    Structural characterization and subcellular localization of Drosophila organic solute carrier partner 1
  6. 7426
    “…Chronic immune activation (IA) is considered as the driving force of CD4(+) T cell depletion and AIDS. Fundamental clues in the mechanisms that regulate IA could lie in natural hosts of SIV, such as African green monkeys (AGMs). …”
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    Innate Immune Responses and Rapid Control of Inflammation in African Green Monkeys Treated or Not with Interferon-Alpha during Primary SIVagm Infection
  7. 7427
    “…Although studies of post-mortem brain tissue provide clues of etiology, the physiological function of Hirano bodies remains unknown. …”
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    Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain
  8. 7428
    “…This study provides further clues to the signalling pathways that regulate internal mRNA translation, an emerging mechanism that allows for increased protein diversity and functional complexity from a single mRNA transcript.…”
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    Internal translation of the connexin 43 transcript
  9. 7429
    “…C. parvum may provide clues to the ancestral state of apicomplexan transcriptional regulation, pre-AP2 domination.…”
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    The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems
  10. 7430
    “…Moreover, it provides interesting clues about molecules with a potential use as vaccine adjuvants, antiviral treatments or markers for vaccine efficiency monitoring.…”
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    Transcriptome Profiles Associated to VHSV Infection or DNA Vaccination in Turbot (Scophthalmus maximus)
  11. 7431
    “…CONCLUSIONS/SIGNIFICANCE: The characterization of the molecular and the temporal and spatial expression patterns of the encoding gene provide first clues as to functions of RIOKs in the biological processes of parasitic nematodes.…”
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    Toward Understanding the Functional Role of Ss-riok-1, a RIO Protein Kinase-Encoding Gene of Strongyloides stercoralis
  12. 7432
    por Nguyen, Scott V., McShan, William M.
    Publicado 2014
    “…The biological and phylogenetic analysis of streptococcal chromosomal islands provides important clues as to how these chromosomal islands help S. pyogenes and other streptococcal species persist in human populations in spite of antibiotic therapy and immune challenges.…”
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    Chromosomal islands of Streptococcus pyogenes and related streptococci: molecular switches for survival and virulence
  13. 7433
    “…Since natural infections induce a longer-lasting immunity than vaccinations, detailed knowledge of the immune responses following natural infection can provide important clues for such improvement. The purpose was to elucidate the kinetics of the protective immune response evolving after experimental Bordetella pertussis (B. pertussis) infection in mice. …”
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    Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection
  14. 7434
    “…A precise understanding of physical and histological changes in teeth subjected to high temperature can provide valuable clues in fire and crime investigations, when dental evidence remains. …”
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    Scorching effects of heat on extracted teeth - A forensic view
  15. 7435
    por Kim, Hyoung Tae, Kim, Ki-Joong
    Publicado 2014
    “…Comparative analyses of complete chloroplast (cp) DNA sequences within a species may provide clues to understand the population dynamics and colonization histories of plant species. …”
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    Chloroplast Genome Differences between Asian and American Equisetum arvense (Equisetaceae) and the Origin of the Hypervariable trnY-trnE Intergenic Spacer
  16. 7436
    “…CONCLUSIONS: Technical, histological, and immunological aspects of a new rat model are described. These results give clues to what occurs in human abdominal wall transplantation. …”
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    A New Rat Model for Orthotopic Abdominal Wall Allotransplantation
  17. 7437
    “…Imunohistochemical studies were carried out to quantify the expression of Bax and Bcl2, the molecular signatures that would provide clues of the extent of neurodegeneration. RESULTS: The activities of enzymes were increased on As administration when compared with those of group II animals. …”
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    Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism
  18. 7438
    “…However, even in adults adaptive immunity following natural infection is poorly protective, allowing re-infection even with the same strain of RSV. This gives us few clues as to how effective vaccination could be achieved. …”
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    Immunity to RSV in Early-Life
  19. 7439
    “…CONCLUSION: Detecting ABA and jasmonic acid response elements on promoter regions of HKTs provide valuable clues on underlying regulatory mechanisms of HKTs. …”
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    In silico analysis of high affinity potassium transporter (HKT) isoforms in different plants
  20. 7440
    “…More generally, we believe that this work provides clues to the process of chemical to thermal to electrical energy conversion inside/outside hybrid nanostructured materials.…”
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    Investigation of the effect of the structure of large-area carbon nanotube/fuel composites on energy generation from thermopower waves
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