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  1. 7461
    “…Many of these genes have previously been reported as significant biomarkers for individual diseases, but others provide new clues to the shared pathological state. Functional analysis showed that overexpressed genes were involved mainly in immune and inflammatory responses, mitotic cell cycles, cytokine-mediated signaling pathways, apoptotic processes, type I interferon–mediated signaling pathways and responses to viruses. …”
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    Shared signatures between rheumatoid arthritis, systemic lupus erythematosus and Sjögren’s syndrome uncovered through gene expression meta-analysis
  2. 7462
    “…This study demonstrates that relative quantitative comparison of endogenous peptides sampled from our protein metabolism by HLA molecules provides clues to understand HLA association with disease. …”
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    Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires
  3. 7463
    “…Both risk indices provide clues to preserve New Caledonia hot spot of biodiversity facing wildfires.…”
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    Wildfire risk for main vegetation units in a biodiversity hotspot: modeling approach in New Caledonia, South Pacific
  4. 7464
    “…In silico genome analysis led to the prediction of metabolic pathways involved in biotransformation of several unusual substrates (e.g., plant-derived volatiles), providing clues on the genomic complement required for such biodegrading/biotransformation functionalities. …”
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    Deciphering the Genome Repertoire of Pseudomonas sp. M1 toward β-Myrcene Biotransformation
  5. 7465
    “…CONCLUSION: Despite some clues suggesting a role of DNAM-1 in arthritis, these complementary approaches demonstrate no contribution of CD226/DNAM-1 in the arthritic phenotype. …”
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    Targeting CD226/DNAX accessory molecule-1 (DNAM-1) in collagen-induced arthritis mouse models
  6. 7466
    “…Additional antibiotic resistance genes were found following comparison with the reference genome, providing some clues pertaining to its survival and colonization in the gut of a patient treated with broad-spectrum antimicrobial agents. …”
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    Whole-genome assembly of Akkermansia muciniphila sequenced directly from human stool
  7. 7467
    “…Our work provides important clues to elucidating the mechanism by which Fam13a may contribute to human lung diseases.…”
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    Regulation of nuclear–cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt
  8. 7468
    “…Such discoveries provide novel clues on how the molecular mechanisms involved in the cell cycle and cell differentiation processes are coordinated during vulval development. …”
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    A model of the regulatory network involved in the control of the cell cycle and cell differentiation in the Caenorhabditis elegans vulva
  9. 7469
    “…The use of modern neuroimaging methods to characterize the complex anatomy of brain development at different stages reveals an enormous wealth of information in understanding this highly ordered process and provides clues to detect neurological and neurobehavioral disorders that have their origin in early structural and functional cerebral maturation. …”
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    New Insights into the Developing Rabbit Brain Using Diffusion Tensor Tractography and Generalized q-Sampling MRI
  10. 7470
    “…Comparative genome analysis of different strains could provide useful clues and insights into the genetic diversity of the species. …”
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    Comparative Whole-Genome Analysis of Clinical Isolates Reveals Characteristic Architecture of Mycobacterium tuberculosis Pangenome
  11. 7471
    “…This investigation provides information concerning DENV-induced miRNAs and offers clues for identifying potential candidates for vector based antiviral strategies. …”
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    The expression profile of Aedes albopictus miRNAs is altered by dengue virus serotype-2 infection
  12. 7472
    “…This work provides mechanistic insight into how milk glycans enrich specific beneficial bacterial populations in infants and reveals clues for enhancing enrichment of bifidobacterial populations in at risk populations - such as premature infants. …”
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    Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants
  13. 7473
    “…Accurate m/z measurements enable the prediction of molecular formulae which provide clues to the chemical identity of peaks, but often a number of metabolites have identical molecular formulae. …”
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    Predicting retention time in hydrophilic interaction liquid chromatography mass spectrometry and its use for peak annotation in metabolomics
  14. 7474
    “…The theory of neuroeconomics can provide important clues for understanding unreasonable human behavior concerning decisions between outcomes occurring at different time points. …”
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    Behavioral economics survey of patients with type 1 and type 2 diabetes
  15. 7475
    “…How nature discriminates sodium from calcium ions in eukaryotic channels has been difficult to resolve because they contain four homologous, but markedly different repeat domains. We glean clues from analyzing the changing pore region in sodium, calcium and NALCN channels, from single-cell eukaryotes to mammals. …”
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    Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels
  16. 7476
    “…Our results provide new clues for functional characterization of miRNAs in the phyB-mediated light signaling pathway, which should be helpful in comprehensively uncovering the molecular mechanisms of phytochrome-mediated photomorphogenesis and stress responses in plants.…”
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    Genome-wide identification of microRNAs and their targets in wild type and phyB mutant provides a key link between microRNAs and the phyB-mediated light signaling pathway in rice
  17. 7477
    “…Finally, our results also suggest a genetic subdivision between coastal and inland A. gambiae Guinean populations and provide clues on the importance of ecological factors in intra-specific differentiation processes.…”
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    Adaptive Potential of Hybridization among Malaria Vectors: Introgression at the Immune Locus TEP1 between Anopheles coluzzii and A. gambiae in ‘Far-West’ Africa
  18. 7478
    “…Blood pressure and heart rate measurements alone may therefore represent an over simplification in the assessment for carotid sinus syndrome and the relative increase in cardiac sympathetic innervation provides additional clues to understanding the mechanisms behind the symptomatic presentation of carotid sinus hypersensitivity.…”
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    Cardiac Iodine-123-Meta-Iodo-Benzylguanidine Uptake in Carotid Sinus Hypersensitivity
  19. 7479
    “…These results expand on previous research to indicate that both differential methylation and differential variability have a role in the etiology and clinical manifestation of depression, and provide clues on specific genomic loci of potential interest in the epigenetics of depression.…”
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    Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins
  20. 7480
    por Hamaneh, Mehdi B, Yu, Yi-Kuo
    Publicado 2015
    “…Identifying similar diseases based on the underlying biomolecular interactions can be especially useful, because it may shed light on the common causes of the diseases and therefore may provide clues for possible treatments. Here we introduce DeCoaD, a web-based program that uses a novel method to assign pair-wise similarity scores, called correlations, to genetic diseases. …”
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    DeCoaD: determining correlations among diseases using protein interaction networks
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