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  1. 7581
    “…We identified genomic “hotspots” of homologous recombination that include regions containing outer membrane proteins, the lipopolysaccharide (LPS) region and Dot/Icm effectors, which provide interesting clues to the selection pressures faced by L. pneumophila. …”
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    Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila
  2. 7582
    “…This study firstly provides valuable insight into the complex regulatory networks underlying phytochrome-mediated anther and pollen development in plants, and offers novel clues for hybrid rice breeding.…”
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    The Rice Phytochrome Genes, PHYA and PHYB, Have Synergistic Effects on Anther Development and Pollen Viability
  3. 7583
    “…CONCLUSION: Ultrasound and computed tomography can provide valuable diagnostic clues for CEF. Laparoscopic management of CEF in experienced hands is safe, feasible, and associated with rapid postoperative recovery.…”
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    Laparoscopic management of cholecystoenteric fistula: A single-center experience
  4. 7584
    “…Our analysis of the PPI network has provided important clues for future detection of the biological roles and mechanisms, as well as the target genes of SMYD3.…”
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    Network analyses elucidate the role of SMYD3 in esophageal squamous cell carcinoma
  5. 7585
    “…Recent advancements in the quality and completeness of human expression microarray data and in their statistical analysis may provide new clues toward the quantitative standardization of human gene expression studies in biology and medicine, both cross- and within-tissue. …”
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    Systematic identification of human housekeeping genes possibly useful as references in gene expression studies
  6. 7586
    “…CONCLUSIONS: Our findings highlight the prominent features of the human charged regions from the DNA up to the protein sequence which might provide potential clues to improve the current understanding of those charged regions and their implication in the emergence of diseases. …”
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    Screening of nucleotide variations in genomic sequences encoding charged protein regions in the human genome
  7. 7587
    “…These findings provide important clues for miRNA determination in human plasma samples.…”
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    Defining quantification methods and optimizing protocols for microarray hybridization of circulating microRNAs
  8. 7588
    “…CONCLUSION: Besides the classic health status measures, the assessment of patients' subjective satisfaction provides important clues on treatments efficacy of OA within the patient-centered medicine model. …”
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    Subjective impact of osteoarthritis flare-ups on patients' quality of life
  9. 7589
    “…We aimed to examine the relationship between CMV infection and the progression of hypertension and hypertensive TOD, which could provide clues on the possible mediating mechanisms, in the Han Chinese population. …”
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    High anti-human cytomegalovirus antibody levels are associated with the progression of essential hypertension and target organ damage in Han Chinese population
  10. 7590
    “…These findings suggest that anomalies of the VA detected in 3-dimensional CTA or MRA may be clues for vertebral artery hypoplasia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12883-017-0951-x) contains supplementary material, which is available to authorized users.…”
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    Are the anomalous vertebral arteries more hypoplastic?: retrospective linear mixed model approach
  11. 7591
    “…These results provide insight into the role of mGluR5 in the regulation of inflammation in the acute phase of TBI, which may provide novel clues for TBI therapy.…”
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    Metabotropic glutamate receptor 5 deficiency inhibits neutrophil infiltration after traumatic brain injury in mice
  12. 7592
    “…Altogether, our data provide valuable clues for the future appraisal of passive oral administration of polyreactive plasma-derived SCIgA/M to combat infection by a variety of enteropathogens.…”
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    Plasma-Derived Polyreactive Secretory-Like IgA and IgM Opsonizing Salmonella enterica Typhimurium Reduces Invasion and Gut Tissue Inflammation through Agglutination
  13. 7593
    “…BACKGROUND: Trichorhinophalangeal syndrome (TRPS) patients tend to have alopecia that appears to be androgenetic, and this genetic model might give clues to the pathogenesis of hair loss or hair morphogenesis. …”
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    Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient
  14. 7594
    “…BACKGROUND: The advent of “omics” science has brought new perspectives in contemporary biology through the high-throughput analyses of molecular interactions, providing new clues in protein/gene function and in the organization of biological pathways. …”
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    CellNetVis: a web tool for visualization of biological networks using force-directed layout constrained by cellular components
  15. 7595
    “…Our goal was to identify spatial clusters of MS incident cases at the small-area level to provide clues to local environmental risk factors that might cause or trigger the disease. …”
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    Small-area distribution of multiple sclerosis incidence in western France: in search of environmental triggers
  16. 7596
    “…Alveolar rhabdomyosarcoma (aRMS) is a pediatric soft tissue cancer commonly associated with a chromosomal translocation that leads to the expression of a Pax3:Foxo1 or Pax7:Foxo1 fusion protein, the developmental underpinnings of which may give clues to its therapeutic approaches. In aRMS, the NFκB–YY1–miR-29 regulatory circuit is dysregulated, resulting in repression of miR-29 and loss of the associated tumor suppressor activity. …”
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    NFκB signaling in alveolar rhabdomyosarcoma
  17. 7597
    “…Describing current practice may give clues to improve AF detection. The aim of this study was to describe how cardiologists currently detect AF. …”
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    Current practice of Dutch cardiologists in detecting and diagnosing atrial fibrillation: results of an online case vignette study
  18. 7598
    “…Our study provided genetic clues for cloning QTLs for both complicated traits.…”
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    Genetic connection between cell-wall composition and grain yield via parallel QTL analysis in indica and japonica subspecies
  19. 7599
    “…The final version of the checklist included42 items across two areas: essential clues for anamnesis and diagnosis of CU; and typical symptoms/parameters or characteristics according to subtype, etiology, and laboratory findings. …”
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    Checklist for a complete chronic urticaria medical history: an easy tool
  20. 7600
    “…Archaeological sites hold important clues to complex climate-human relationships of the past. …”
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    Altered cropping pattern and cultural continuation with declined prosperity following abrupt and extreme arid event at ~4,200 yrs BP: Evidence from an Indus archaeological site Khirsara, Gujarat, western India
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