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  1. 7641
    por Yang, Jie, Li, Bin, He, Qing-Yu
    Publicado 2018
    “…As more efficient biomarkers and targets are urgently needed for cancer diagnosis and treatment, here we summarize the functional role of prohibitin domain family proteins, focusing on PHB1 and PHB2 in tumorigenesis and cancer development, with the expectation that targeting the prohibitin domain family will offer more clues for cancer therapy.…”
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    Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment
  2. 7642
    “…The present study would provide clues to clarify the feeding mechanism of the bloodsucking lampreys. …”
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    Proteomic analysis of buccal gland secretion from fasting and feeding lampreys (Lampetra morii)
  3. 7643
    “…Gene transcription patterns within bone marrow and pulmonary lymph nodes of affected horses may offer clues to disease pathobiology. Bone marrow core and tracheobronchial lymph node tissue samples harvested postmortem from affected and unaffected horses were examined histologically and subjected to RNA sequencing (RNA-seq). …”
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    Bone formation transcripts dominate the differential gene expression profile in an equine osteoporotic condition associated with pulmonary silicosis
  4. 7644
    “…A better understanding on interplay between IAV and host factors may provide clues for disease prevention and control. While many viruses are known to downregulate p53 upon entering the cell to reduce the innate host antiviral response, IAV infection is unusual in that it activates p53. …”
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    Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins
  5. 7645
    “…Finally, our research on the language use may provide essential clues to distinguish complementary trends in the use of language in Twitter when analysing health-related topics.…”
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    Disease mentions in airport and hospital geolocations expose dominance of news events for disease concerns
  6. 7646
    “…Using various mouse models of Notch signaling pathway depletion, we analyze the effects of its absence on type 1 ILC differentiation and cytotoxic functions. We also provide clues into its role in the maintenance of immune homeostasis in tissues. …”
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    The Notch Signaling Pathway Is Balancing Type 1 Innate Lymphoid Cell Immune Functions
  7. 7647
    “…This phenomenon is poorly understood, but rodent models may provide clues. We have previously shown that aging (24-mo-old) F344xBN rats generally do not show significant physical or cognitive impairments. …”
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    Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium
  8. 7648
    “…Epidemiological studies can provide aetiological clues for prevention. The prevalence of oral cancer in densely populated cities in eastern China is unclear. …”
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    Oral cancer incidence in Shanghai ---- a temporal trend analysis from 2003 to 2012
  9. 7649
    por Rahimi, Arezou, Gönen, Mehmet
    Publicado 2018
    “…We also showed that our algorithm was able to extract meaningful and disease-specific information that gives clues about the progression mechanism. AVAILABILITY AND IMPLEMENTATION: Our implementations of support vector machine and multiple kernel learning algorithms in R are available at https://github.com/mehmetgonen/gsbc together with the scripts that replicate the reported experiments.…”
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    Discriminating early- and late-stage cancers using multiple kernel learning on gene sets
  10. 7650
    “…We also knocked down the two constitutively most expressed genes in the integument of resistant T. infestans nymphs (CYP3093A11 and CYP4EM10) in order to find clues on their participation in deltamethrin resistance. …”
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    Integument CYP genes of the largest genome-wide cytochrome P450 expansions in triatomines participate in detoxification in deltamethrin-resistant Triatoma infestans
  11. 7651
    “…These findings would provide clues for identifying individuals at high risk of HOA.…”
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    TLR10 and NFKBIA contributed to the risk of hip osteoarthritis: systematic evaluation based on Han Chinese population
  12. 7652
    “…We also found significant differences between cells expressing or lacking the Rnq1 protein which forms the [RNQ(+)] prion, providing new clues to the as yet unresolved normal biological function of this prion-forming protein. …”
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    Using High Performance Thin Layer Chromatography-Densitometry to Study the Influence of the Prion [RNQ(+)] and Its Determinant Prion Protein Rnq1 on Yeast Lipid Profiles
  13. 7653
    “…We conclude that the PTG/Cas9 system is a more powerful system than the traditional CRISPR/Cas9 system for kiwifruit genome editing, which provides valuable clues for optimizing CRISPR/Cas9 editing system in other plants.…”
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    Optimized paired‐sgRNA/Cas9 cloning and expression cassette triggers high‐efficiency multiplex genome editing in kiwifruit
  14. 7654
    “…Detailed knowledge of cancer cell proliferation mechanisms would not only benefit understanding of cancer progression, but may also provide new clues for developing novel therapeutic strategies. …”
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    Motor neuron and pancreas homeobox 1/HLXB9 promotes sustained proliferation in bladder cancer by upregulating CCNE1/2
  15. 7655
    “…This study provides a global view of the complex network underlying the acquired nif genes in the recombinant E. coli and also provides clues for the optimization and redesign of robust nitrogen-fixing organisms to improve nitrogenase efficiency by overcoming regulatory or metabolic obstacles.…”
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    Global investigation of an engineered nitrogen-fixing Escherichia coli strain reveals regulatory coupling between host and heterologous nitrogen-fixation genes
  16. 7656
    “…A family history of the subject comprising the timing of puberty in the parents and physical examination may provide clues regarding the cause of DP. Delayed onset of puberty is rarely considered a disease in either sex. …”
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    Delayed puberty versus hypogonadism: a challenge for the pediatrician
  17. 7657
    “…These findings with a Drosophila model that mimics FTLD provide clues for the development of novel FTLD therapies.…”
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    NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene
  18. 7658
    “…The influence of early life exposures on later life disease has for some time provided clues to modifiable risk factors of disease. The “atopic march” is thought to play a role in the progression of allergic diseases and may offer an opportunity to lower asthma’s health and socioeconomic burden, although evidence remains controversial. …”
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    Association of Infant Eczema with Childhood and Adult Asthma: Analysis of Data from the 1958 Birth Cohort Study
  19. 7659
    “…Finally, we described high-resolution distributions of SAVs along the gene and their splicing outcomes in commonly disrupted genes, including TP53, PIK3R1, GATA3, and CDKN2A, which offers genetic clues for understanding their functional properties. …”
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    A comprehensive characterization of cis-acting splicing-associated variants in human cancer
  20. 7660
    por Yoo, Sunyong, Nam, Hojung, Lee, Doheon
    Publicado 2018
    “…Although natural compounds have provided a wealth of leads and clues in drug development, the process of identifying their pharmacological effects is still a challenging task. …”
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    Phenotype-oriented network analysis for discovering pharmacological effects of natural compounds
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