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  1. 7901
    “…The presence of infection promotes the generation of resistance alleles, and there are some evolutionary and genetic clues that suggest the presence of an iron deficiency phenotype that may have developed to protect against infection. …”
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    Low iron mitigates viral survival: insights from evolution, genetics, and pandemics—a review of current hypothesis
  2. 7902
    “…Conclusion: The present study developed a comprehensive tool to identify the immunoparalysis endotype and immunocompetent status in hospitalized patients with sepsis and provides novel clues for further targeting of therapeutic approaches.…”
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    Classification of Patients With Sepsis According to Immune Cell Characteristics: A Bioinformatic Analysis of Two Cohort Studies
  3. 7903
    “…Our study provides important clues to understand the immune response observed in COVID‐19 patients, associating severity with an imbalanced humoral response, and identifying new targets for therapeutic intervention.…”
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    Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID‐19 patients
  4. 7904
    “…Current evidence suggests a complex interplay between EMT, genetic and epigenetic alterations, and clues from the tumor microenvironment in cell reprogramming. …”
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    The Intimate Relationship among EMT, MET and TME: A T(ransdifferentiation) E(nhancing) M(ix) to Be Exploited for Therapeutic Purposes
  5. 7905
    “…Our results provide new clues for further development of Aurora-A kinase inhibitors as anticancer molecules.…”
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    Structure-Based Discovery and Bioactivity Evaluation of Novel Aurora-A Kinase Inhibitors as Anticancer Agents via Docking-Based Comparative Intermolecular Contacts Analysis (dbCICA)
  6. 7906
    “…Our results furnished new hints of immune profiling of ESCC, which may provide some clues to further optimize associated cancer immunotherapies.…”
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    Identification of a Prognostic Immune Signature for Esophageal Squamous Cell Carcinoma to Predict Survival and Inflammatory Landscapes
  7. 7907
    “…Our findings provide biological clues for these PanC risk‐associated SNPs in cadherin‐related genes in European ancestry populations, possibly by regulating the expression of the affected genes. …”
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    Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk
  8. 7908
    por Zhang, Shi
    Publicado 2020
    “…CONCLUSION: The present study developed a comprehensive tool to identify immunoparalysis endotype and immunocompetent status in sepsis be hospitalized and provides novel clues for further targeting of therapeutic approaches. …”
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    586. Classification of patients with sepsis according to immune cell characteristics: a bioinformatic analysis of two cohort studies
  9. 7909
    “…As expected, the results showed that top universities have strong research profiles, becoming the leaders in the world in those areas and cosine similarity pointed out that some are more affine among them than others. The results provide clues for enhancing existing collaboration, defining and re-directing lines of research, and seeking for new partnerships to face the current pandemic to find was to tackle down the covid-19 outbreak.…”
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    Quantifying the publication preferences of leading research universities
  10. 7910
    “…These findings will provide us with important clues for antiviral therapy against NDV infection.…”
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    gga-miR-1603 and gga-miR-1794 directly target viral L gene and function as a broad-spectrum antiviral factor against NDV replication
  11. 7911
    “…Burned or charred organic matter in anthropogenic combustion features may provide important clues about past human activities related to fire. …”
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    Characterisation of charred organic matter in micromorphological thin sections by means of Raman spectroscopy
  12. 7912
    “…MYC is a key oncogene activated across most cancers, and identifying associated synthetic lethality or sickness can provide important clues about its activity and potential therapeutic strategies. …”
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    The UVSSA complex alleviates MYC-driven transcription stress
  13. 7913
    “…BACKGROUND AND OBJECTIVES: Clues show that a large number of toxic agents, including carcinogenic, heavy metals, other particles, and high levels of nicotine, are effectively delivered through cigarette and hookah smoking. …”
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    Cigarette and Hookah Smoking in Adolescent Students using World Health Organization Questionnaire Global Youth Tobacco Survey (GYTS): A Pilot Study in Varamin City, Iran in 2016
  14. 7914
    “…The knowledge and ideas on the application of LUS in the management of pneumonia that are expected to accumulate in the COVID-19 era may provide us with clues regarding more appropriate management.…”
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    Point-of-care lung ultrasound for the assessment of pneumonia: a narrative review in the COVID-19 era
  15. 7915
    “…These studies also provide tantalizing clues into the possibility that neurons actively choose how tau is post-translationally modified, in potentially competitive and combinatorial ways, to achieve broad, cellular programs commensurate with the distinctive environmental conditions found during development, aging, stress, and disease. …”
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    Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation
  16. 7916
    “…Our review aims to provide new clues for researchers to develop novel strategies and methods for the diagnosis and treatment of HPV-induced tumors.…”
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    Immunodiagnosis and Immunotherapeutics Based on Human Papillomavirus for HPV-Induced Cancers
  17. 7917
    “…Herein, we explored the dynamic changes of epigenetic modifications in the malignant transformation process of CTP-induced BEAS-2B cells and also provided clues for screening early biomarkers of CTP-associated occupational lung cancer. …”
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    Epigenetic-Based Biomarkers in the Malignant Transformation of BEAS-2B Cells Induced by Coal Tar Pitch Extract
  18. 7918
    “…Our study provides some crucial clues about the potential dynamic mechanism for LBPP training on gait and balance improvement, which is related to rebuilding foot pressure distribution and remodeling symmetry of biomechanics of the lower limb.…”
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    Dynamic biomechanical effect of lower body positive pressure treadmill training for hemiplegic gait rehabilitation after stroke: A case report
  19. 7919
    “…These results provide novel insights into the replication mechanism of CoV and new clues for future drug design.…”
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    Structure of the multiple functional domains from coronavirus nonstructural protein 3
  20. 7920
    “…Our research may facilitate the understanding of the impacts of COVID-19 pandemic on our society and environment, and also provide clues to adapt to this unprecedented pandemic so as to respond to similar events in the future.…”
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    Impacts of COVID-19 pandemic on user behaviors and environmental benefits of bike sharing: A big-data analysis
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