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  1. 7981
    por Tanaka, Hidekazu
    Publicado 2021
    “…This mapping is clinically practicable and the plot patterns obtainable as the result of further development of this technique for clinical practice provide clues to the etiology of cardiomyopathies. This article reviews the efficacy of echocardiography for differential diagnosis of LVH, with a special focus on the utility of speckle-tracking longitudinal strain.…”
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    Efficacy of echocardiography for differential diagnosis of left ventricular hypertrophy: special focus on speckle-tracking longitudinal strain
  2. 7982
    “…Future work addressing the consequences of these changes may provide important clues for prevention of lung disease and for lung bioengineering and ultimately pave the way to novel targeted approaches in lung regenerative medicine.…”
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    Collagen Biosynthesis, Processing, and Maturation in Lung Ageing
  3. 7983
    “…Single‐nucleotide polymorphisms (SNP) and long non‐coding RNAs (lncRNAs) have been involved in the process of lung cancer. Following clues given by lung cancer risk‐associated SNP, we aimed to find novel functional lncRNAs as candidate targets in lung cancer. …”
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    Single‐nucleotide polymorphism rs4142441 and MYC co‐modulated long non‐coding RNA OSER1‐AS1 suppresses non‐small cell lung cancer by sequestering ELAVL1
  4. 7984
    por Wang, Peng, Li, Ying, Li, Lu, Zhong, Rong, Shen, Na
    Publicado 2021
    “…This study provides some clues to identify the “truth” of potential disease-related genetic factors in the post-genome era.…”
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    MBOAT7-TMC4 rs641738 Is Not Associated With the Risk of Hepatocellular Carcinoma or Persistent Hepatitis B Infection
  5. 7985
    “…Therefore, the deregulation of miR-145 provides clues as to the potential role in penile carcinogenesis and is also a potential candidate for validation in noninvasive samples.…”
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    Downregulation of miR-145 is associated with perineural invasion in penile carcinoma
  6. 7986
    “…OBJECTIVE: To report Peutz–Jeghers syndrome (PJS) cases with non-definitive clues in the family or personal history and finally diagnosed through pathological examination and STK11 gene mutation test. …”
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    Delayed diagnosis of Peutz–Jeghers syndrome due to pathological information loss or mistake in family/personal history
  7. 7987
    “…Interestingly the self-referential judgement that we impose is an individual-level behaviour with no direct collective benefit shared by the population. The study provides clues, beyond qualitative and observational studies, as to how hypocrisy may have established itself to reinforce the collective benefit of a fused group identity. …”
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    The evolution of strongly-held group identities through agent-based cooperation
  8. 7988
    “…Based on the molecular hybridization strategy, 14 compounds with EGFR inhibitory activity were designed and synthesized, and the action mechanism was explored through computational approaches, providing valuable clues for the research of antitumor agents based on EGFR inhibitors.…”
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    Discovery of Potent EGFR Inhibitors With 6-Arylureido-4-anilinoquinazoline Derivatives
  9. 7989
    “…Elucidating the features of tumor suppressor genes (TSGs) and the corresponding signal transduction cascade may provide clues for the development of new strategies for targeted therapy of THCA. …”
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    The Novel Tumor Suppressor Gene ZNF24 Induces THCA Cells Senescence by Regulating Wnt Signaling Pathway, Resulting in Inhibition of THCA Tumorigenesis and Invasion
  10. 7990
    “…These results provided valuable insights into the clues underlying the pathogenesis of PD.…”
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    RNA-sequencing of peripheral blood circular RNAs in Parkinson disease
  11. 7991
    “…However, signs of fluid redistribution are clues that favor HF over COVID-19 pneumonia.…”
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    Comparing Lung CT in COVID-19 Pneumonia and Acute Heart Failure: An Imaging Conundrum
  12. 7992
    “…Minerals contain important clues to understanding the complex geologic history of Earth and other planetary bodies. …”
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    Online Artículo Texto
    Global earth mineral inventory: A data legacy
  13. 7993
    “…The echocardiographic findings showed thickened interventricular septal and left posterior ventricular walls. Based on the clues mentioned earlier, we realized the possibility of AFD. …”
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    Anderson-Fabry disease presenting with atrial fibrillation as earlier sign in a young patient: A case report
  14. 7994
    “…Taken together, our results reveal the macro- and micro-phenotype variations as well as gene expression profiles between GS and NS, which could provide valuable clues for elucidating the mechanism of the color variation of Aquilaria.…”
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    Comparative anatomical and transcriptomic analyses of the color variation of leaves in Aquilaria sinensis
  15. 7995
    “…Such approaches will provide clues for potential future viral outbreak, saving financial resources by reducing testing necessities for viral detection, hence contributing for more appropriate confinement policies by governments and could be further used to define more precisely post-pandemic or additional waves measures if/ when needed.…”
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    Challenges to detect SARS-CoV-2 on environmental media, the need and strategies to implement the detection methodologies in wastewaters
  16. 7996
    “…Purpose: This study aimed to identify the potential prognostic role of HK3 and provide clues about glycolysis and the microenvironmental characteristics of ccRCC. …”
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    Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment
  17. 7997
    “…This may shed light on the mechanism understanding of NPC prognosis and provide more novel clues for NPC diagnosis and therapy.…”
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    S100A8/A9 Molecular Complexes Promote Cancer Migration and Invasion via the p38 MAPK Pathway in Nasopharyngeal Carcinoma
  18. 7998
    “…Our findings not only lay a foundation for further functional characterization of BnMYB-related genes, but also provide valuable clues to determine candidate genes for future genetic improvement of B. napus.…”
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    Genome-Wide Analysis of Myeloblastosis-Related Genes in Brassica napus L. and Positive Modulation of Osmotic Tolerance by BnMRD107
  19. 7999
    “…Identification of poor responders by genotype could avoid unnecessary treatment and provide clues to the underlying mechanism of action. GWAS identified SNPs associated with metformin treatment success at a locus containing the NPAT (nuclear protein, ataxia-telangiectasia locus) and ATM (ataxia-telangiectasia mutated) genes. …”
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    The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection
  20. 8000
    “…Overall, our mouse model recapitulates olfactory dysfunction in COVID-19 patients and provides critical clues for understanding the physiological basis for extrapulmonary manifestations of COVID-19.…”
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    SARS-CoV-2 infection in the mouse olfactory system
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