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  1. 8161
    “…Our research provides theoretical clues for the in-depth unveiling of the defense mechanisms underlying the synergistic effect of fine-tuned Asp pathway enzymes and the linked metabolite flux in Populus.…”
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    New Insight into Aspartate Metabolic Pathways in Populus: Linking the Root Responsive Isoenzymes with Amino Acid Biosynthesis during Incompatible Interactions of Fusarium solani
  2. 8162
    “…Our results also emphasize the need to study the finer soil fractions, as they provide clues both on soil formation and bone diagenesis.…”
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    Understanding Necrosol pedogenetical processes in post-Roman burials developed on dunes sands
  3. 8163
    “…These new findings provide crucial clues to identify anti-inflammatory dietary components as effective therapeutic approaches in the management of CHD, while also providing some insights into their mechanisms of action.…”
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    Association Between Dietary Intakes and Plaque Vulnerability Measured by Optical Coherence Tomography in Patients With Coronary Heart Disease: A Mediation Analysis of Inflammatory Factors
  4. 8164
    “…RNA sequencing has provided valuable and important mechanistic clues regarding FAdV-4–host interactions. However, the pathogenic mechanism and host's responses after FAdV-4 infection remains limited. …”
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    Transcriptome Analysis of Genes Responding to Infection of Leghorn Male Hepatocellular Cells With Fowl Adenovirus Serotype 4
  5. 8165
    “…This study fills this gap by employing the Heuristic-Systematic Model and investigating the effects of the heuristic clues including social media capital, information richness, language features, dialogic loop, and the systematic clue including content types, on citizen engagement with government social media across three different stages of the pandemic, employing the moderating role of emotional valence. …”
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    Does Citizen Engagement With Government Social Media Accounts Differ During the Different Stages of Public Health Crises? An Empirical Examination of the COVID-19 Pandemic
  6. 8166
    “…The SG initiation mechanism, via Lsm7 phase separation, identified in this work provides valuable clues for understanding the mechanisms underlying SG formation and SG-associated human diseases.…”
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    Lsm7 phase-separated condensates trigger stress granule formation
  7. 8167
    “…Our study contributes to understanding the function of prM and M proteins and provides new clues for live vaccine designation for JEV.…”
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    Increased Cleavage of Japanese Encephalitis Virus prM Protein Promotes Viral Replication but Attenuates Virulence
  8. 8168
    “…The results revealed the characteristics of TME in post-chemotherapy oral squamous cell carcinoma at single-cell transcriptome level, providing new insights and clues for further investigation.…”
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    Single-Cell Transcriptome Analysis Reveals Changes of Tumor Immune Microenvironment in Oral Squamous Cell Carcinoma After Chemotherapy
  9. 8169
    “…These findings add new clues for a better comprehension of strain selection dynamics in prion infections and have wider implications for understanding the origin of contagious prion strains, such as CS.…”
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    A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants
  10. 8170
    “…These findings comprehensively provided key clues for developing m(5)C regulators-related effective therapeutic targets and promising diagnostic biomarkers in breast cancer.…”
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    A Comprehensive Analysis for Expression, Diagnosis, and Prognosis of m(5)C Regulator in Breast Cancer and Its ncRNA–mRNA Regulatory Mechanism
  11. 8171
    “…Our findings thus reveal a previously unappreciated role of the Nsd2-dependent chromatin remodeling during spermatogenesis and provide clues to the molecular mechanisms in epigenetic abnormalities impacting male reproductive health.…”
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    H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis
  12. 8172
    “…Our findings provide preliminary information about the possible cortical etiology of facial asymmetry, and deliver valuable clues regarding spatial information, which will likely be useful for the development of therapeutic interventions.…”
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    Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry
  13. 8173
    “…Our findings will provide important clues for expanding sample screening and will contribute to the reasonable allocation of medical resources.…”
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    Epidemiological Trends of Coronavirus Disease 2019 in Sierra Leone From March 2020 to October 2021
  14. 8174
    “…The study revealed the biological significance of poplar Dof transcription factors in N response and regulation of related downstream gene expression and provided some meaningful clues to explain the huge difference between poplar and Arabidopsis thaliana transformed by exogenous Dof gene, which could promote the comprehensive understanding of the molecular mechanism of efficient N uptake and utilization in trees.…”
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    Selection and functional identification of Dof genes expressed in response to nitrogen in Populus simonii × Populus nigra
  15. 8175
    “…BACKGROUND: Although hereditary ataxias are a group of clinically and genetically heterogeneous disorders, specific clinical clues can sometimes incriminate certain genes. This can trigger genetic testing in sporadic patients or prompt dissecting certain genes more thoroughly when initial genetic testing is negative. …”
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    RNF170 mutation causes autosomal dominant sensory ataxia with variable pyramidal involvement
  16. 8176
    “…There are orthologous NLRs (orthogroups) shared between coffee, tomato, potato, and reference NLRs and those that are shared only among coffee species, which provides clues about the functionality and evolutionary history of these orthogroups. …”
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    Genome-Wide Identification, Characterization, and Comparative Analysis of NLR Resistance Genes in Coffea spp.
  17. 8177
    “…Conclusion: This bibliometric analysis conducted a full overview of the treatment of liver fibrosis, which provided important clues and ideas for scholars focusing on this field. …”
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    Treatment of Liver Fibrosis: A 20-Year Bibliometric and Knowledge-Map Analysis
  18. 8178
    “…Our study identified multiple candidate genes associated with PTSD in the proteome and transcriptome levels, which may provide new clues to the pathogenesis of PTSD.…”
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    Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder
  19. 8179
    “…Raw materials of PSBs are often similar to those of heavy-duty tools in assemblages, which could provide other clues about their functions (e.g., tasks requiring a resistance to shocks). …”
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    Palaeolithic polyhedrons, spheroids and bolas over time and space
  20. 8180
    “…We also intended to discuss the pathogenesis of hypothyroidism in SLE patients, which would provide clues for further investigation. METHODS: This study recruited 856 SLE patients and 856 age- and sex-matched healthy population and compared the prevalence of hypothyroidism between the cases and controls. …”
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    Systemic Lupus Erythematosus Patients With Related Organic Damage Are at High Risk of Hypothyroidism
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