“…The computational prediction of the functional sites for protein structures of unknown function provides valuable clues for functional classification.…”
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“…Finally, the sequences of the Cjd napA and napB loci suggest that Cjd strains arose from a common ancestor, providing clues as to the potential evolutionary origin of Cjd.…”
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“…Characteristic nucleotide preferences observed within variable regions provide potential clues regarding the transcription and maturation of T. cruzi guide RNAs. …”
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“…Species differences in brain expression profiles for functionally related groups of genes provide possible clues to the basis of behavioral variation in the genus.…”
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“…Aberrant receptor processing may provide clues concerning the role of FGF's and their potential involvement in malignancy. …”
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“…These findings may provide clues to the underlying aetiology of childhood cancer, as congenital malformations are felt to be a marker of exposures or processes which may increase cancer risk. …”
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“…These results provide promising targets for future experimental investigation as well as potential clues for understanding the functional basis of lifespan extension in mammalian systems.…”
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“…The sequences of the VPS29, VPS30, and VPS35 genes do not yet give any clues to the functions of their products. Each is predicted to encode a hydrophilic protein with homologues in the human and C. elegans genomes. …”
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“…Lymphocytes sense both the presence of an antigen and also clues from antigen-presenting cells, which dictate the requisite response. …”
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“…CONCLUSIONS/SIGNIFICANCE: These findings illustrate novel cellular functions of non-lens βγ-cyrstallins and action mechanism via association with trefoil factors, serving as clues for investigating the possible occurrence of similar molecules and action mechanisms in mammals.…”
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“…This sequence information, along with other molecular tools, have been used to estimate the evolutionary history of the group and provide clues to understand the capacity of Xf to infect different hosts, causing a variety of symptoms. …”
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“…CONCLUSION: This study demonstrates how novel models of breast cancer can provide new fundamental clues regarding cancer etiology which may lead to new human treatments and therapies.…”
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“…An association between BCP ALL and HLA class II (DR, DQ, DP) alleles could provide further clues to the identity of the infection, since HLA molecules exhibit allotype-restricted binding of infection-derived antigenic peptides. …”
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“…Furthermore, by extending the knowledge of the polymorphic effects of IFN-α on gene expression, they offer novel clues to the study of its pleiotropic toxicity. © 2001 Cancer Research Campaign http://www.bjcancer.com…”
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“…METHODOLOGY/PRINCIPAL FINDINGS: After cloning, overexpression, and purification, the thymidylate-synthesizing ability of ThyA and ThyX gene products were directly confirmed by HPLC analysis of reaction products and substrate saturation kinetics were established. 5-Fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) was a potent inhibitor of both ThyA and ThyX, offering important clues to double-targeting strategies. In contrast, the folate-based 1843U89 was a potent inhibitor of ThyA but not ThyX suggesting that it should be possible to find ThyX-specific antifolates. …”
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“…This tool was successfully exploited for a quick mapping of complex families of genes, and it strengthened previous clues of co-localisation of major NBS-LRR clusters and disease resistance loci in grapevine.…”
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“…LS is largely overlapping Noonan syndrome and, during childhood, Neurofibromatosis type 1-Noonan syndrome. Diagnostic clues of LS are multiple lentigines and CLS, hypertrophic cardiomyopathy and deafness. …”
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“…Non-homology methods are thus needed to obtain functional clues for these uncharacterized genes. RESULTS: We present PlasmoDraft , a database of Gene Ontology (GO) annotation predictions for P. falciparum genes based on postgenomic data. …”
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“…CONCLUSION: BNs can be used to achieve accurate identification of alternative exons and provide clues about possible dependencies between relevant features. …”
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“…CONCLUSION: Our findings demonstrate previously unrecognized changes in gene transcription that are associated with HPS infection in vivo, and many potential cascades identified in the study clearly merit further investigation. Our data provide new clues to the nature of the immune response in mammals, and we have identified candidate genes that are related to resistance to HPS.…”
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