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  1. 8541
    por Hart, David A.
    Publicado 2016
    “…Elucidating such details may provide important clues for development of effective treatment for patients with SLE, ~90 % of which are females.…”
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    Sex-specific effects of LiCl treatment on preservation of renal function and extended life-span in murine models of SLE: perspective on insights into the potential basis for survivorship in NZB/W female mice
  2. 8542
    “…Although serum IgG4 levels increased with the number of involved organs, serum IgG4 levels were higher for those patients with salivary gland/lacrimal gland swelling compared with those with internal organ involvement. Thus, valuable clues to the differential diagnosis of IgG4-RD could be obtained by examining the clinical patterns of organ involvement.…”
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    Types of Organ Involvement in Patients with Immunoglobulin G4-related Disease
  3. 8543
    “…This has generated distinct patterns of genome-wide diversity that provide new clues about the demographic history of these populations. …”
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    A genome-wide perspective about the diversity and demographic history of seven Spanish goat breeds
  4. 8544
    “…Our data provide some clues to understanding the role of VAAM in metabolic regulation. …”
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    Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species
  5. 8545
    “…In addition, a cytoscape network will provide some clues for research into the complex biological processes that occur in this unique alga. …”
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    Identification of conserved and novel microRNAs in Porphyridium purpureum via deep sequencing and bioinformatics
  6. 8546
    “…These results indicate that PI4Kγ5 interacts with ANAC078 to negatively regulate auxin synthesis and hence influences cell proliferation and leaf development, providing informative clues for the regulation of in situ auxin synthesis and cell division, as well as the cleavage and functional mechanism of membrane-bound transcription factors.…”
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    Arabidopsis Type II Phosphatidylinositol 4-Kinase PI4Kγ5 Regulates Auxin Biosynthesis and Leaf Margin Development through Interacting with Membrane-Bound Transcription Factor ANAC078
  7. 8547
    “…Here, we explore the concept that specific types of infectious diseases that are more common among HEU infants could provide clues as to the potential underlying immunological abnormalities. …”
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    Linking Susceptibility to Infectious Diseases to Immune System Abnormalities among HIV-Exposed Uninfected Infants
  8. 8548
    “…This study helps provide a better understanding of CYP3A regulation and offers novel clues for the role of miRNAs in the metabolism and distribution of environmental pollutants.…”
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    BDE47 induces rat CYP3A1 by targeting the transcriptional regulation of miR-23b
  9. 8549
    “…Our study indicates that levels of FVII, but not TF, are associated with tumor migration and invasiveness in HCC, and provides clues that evaluation of FVII expression in HCC may be useful as a prognostic indicator in patients with HCC and may form an alternative target for further therapy.…”
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    Factor VII promotes hepatocellular carcinoma progression through ERK-TSC signaling
  10. 8550
    “…Moreover, analysis of the accessory genome provides important clues as to the genetic changes underpinning host adaptation and, in particular, shows that human-to-monkey switches tend to be associated with the loss of genes known to confer adaptation to the human host.…”
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    Transmission of Staphylococcus aureus from Humans to Green Monkeys in The Gambia as Revealed by Whole-Genome Sequencing
  11. 8551
    “…Clarification of these issues will provide clues to implement possible therapeutic strategies for DNAJB6-related myopathies.…”
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    DNAJB6 Myopathies: Focused Review on an Emerging and Expanding Group of Myopathies
  12. 8552
    “…It was hypothesised that early gestation protein restriction would impact upon placental gene expression and that this may give clues to the mechanism which links maternal diet to later consequences. …”
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    The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport
  13. 8553
    “…Finally we studied risk factors for hypothermia in an attempt to find new clues to the etiology of hypothermia in sepsis. METHODS: Consecutive patients diagnosed with sepsis within 24 hours after admission to ICUs in two tertiary hospitals in the Netherlands were included in the study (n = 525). …”
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    Risk factors, host response and outcome of hypothermic sepsis
  14. 8554
    “…Analyses of the haplotype structure in samples taken at different times could give clues to possible causes of selection. METHODS: This study investigates chromosome 6 extended haplotypes in The Gambia by analysing alleles at multiple microsatellite loci using genome sequence data previously obtained from clinical isolates collected in 2008, followed by genotyping of 13 loci in 439 isolates from 1984, 1991, 2008 and 2014. …”
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    Exceptionally long-range haplotypes in Plasmodium falciparum chromosome 6 maintained in an endemic African population
  15. 8555
    “…Such information could ultimately provide clues and point towards molecular pathways that are susceptible to aging-related disease-associated epigenetic dysregulation. …”
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    Intra-individual changes in DNA methylation not mediated by cell-type composition are correlated with aging during childhood
  16. 8556
    “…Understanding common causes and intrinsic differences in disease‐associated synaptic dysfunction could offer novel clues toward synapse‐based therapeutic intervention for neurological and neuropsychiatric disorders. …”
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    Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students
  17. 8557
    “…Our findings provide important clues for further studies of the molecular mechanisms underlying cold stress responses in plants. …”
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    De novo transcriptome sequencing and gene expression profiling of Elymus nutans under cold stress
  18. 8558
    “…A better understanding of SP cells may provide new clues for detecting and targeting these cancer-initiating cells and ultimately help to eradicate cancer. …”
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    Integrated glycomic analysis of ovarian cancer side population cells
  19. 8559
    “…CONCLUSIONS: These findings provided important clues about the role of integron-mediated resistance genes together with other independent resistance genes and chromosomal mutations in shaping the epidemiology of antimicrobial resistance in E. coli isolates from poultry farms in Egypt.…”
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    Genetic elements associated with antimicrobial resistance among avian pathogenic Escherichia coli
  20. 8560
    “…CONCLUSION: miR-324-3p could suppress the migration and invasion of NPC by targeting WNT2B and the miR-324-3p/WNT2B pathway possibly provide new potential therapeutic clues for NPC. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12935-016-0372-8) contains supplementary material, which is available to authorized users.…”
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    miR-324-3p suppresses migration and invasion by targeting WNT2B in nasopharyngeal carcinoma
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