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8561por Li, Yung-Tsung, Liu, Chun-Jen, Su, Tung-Hung, Cheng, Huei-Ru, Jeng, Yung-Ming, Lin, Hsiu-Lin, Wang, Chih-Chiang, Kao, Jia-Horng, Chen, Pei-Jer, Chen, Ding-Shinn, Wu, Hui-Lin“…In conclusion, our results support the hypothesis that woodchuck HCC recapitulates HBV-associated HCC with respect to the molecular characteristics of MTA1 and provides new clues for conducting mechanistic studies of MTA1 in HBV-associated hepatocarcinogenesis, including the possible clinical significance of wk-MTA1dE4.…”
Publicado 2016
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8562por Iguchi, Kohta, Hatano, Etsuro, Nirasawa, Takashi, Iwasaki, Noriyuki, Sato, Motohiko, Yamamoto, Gen, Yamanaka, Kenya, Okamoto, Tatsuya, Kasai, Yosuke, Nakamura, Naohiko, Fuji, Hiroaki, Sakai, Tomohito, Kakuda, Nobuto, Seo, Satoru, Taura, Kojiro, Tashiro, Kei, Uemoto, Shinji, Ikegawa, Masaya“…This strategy is feasible for application to human biomarker studies and will yield clues for understanding liver regeneration in human clinical trials.…”
Publicado 2017
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8563por Toyoshima, M, Akamatsu, W, Okada, Y, Ohnishi, T, Balan, S, Hisano, Y, Iwayama, Y, Toyota, T, Matsumoto, T, Itasaka, N, Sugiyama, S, Tanaka, M, Yano, M, Dean, B, Okano, H, Yoshikawa, T“…Given the complexity and heterogeneity of the genomic architecture underlying schizophrenia, molecular analyses of these patients with defined and large effect-size genomic defects could provide valuable clues. We established human-induced pluripotent stem cells from two schizophrenia patients with the 22q11.2 deletion (two cell lines from each subject, total of four cell lines) and three controls (total of four cell lines). …”
Publicado 2016
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8564por Baldia, Philipp H., Maurer, Angela, Heide, Timon, Rose, Michael, Stoehr, Robert, Hartmann, Arndt, Williams, Sarah V., Knowles, Margaret A., Knuechel, Ruth, Gaisa, Nadine T.“…Hence, our comprehensive study provides novel insights into a subgroup of squamous differentiated bladder tumors that hold clues for novel therapeutic regimens and may benefit from FGFR3-targeted therapies.…”
Publicado 2016
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8565“…DISCUSSION: By taking a systemic approach to gene function in vision, the results provide the first molecular clues associated with giraffe and okapi vision adaptations. …”
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8566por Oberbach, Andreas, Schlichting, Nadine, Feder, Stefan, Lehmann, Stefanie, Kullnick, Yvonne, Buschmann, Tilo, Blumert, Conny, Horn, Friedemann, Neuhaus, Jochen, Neujahr, Ralph, Bagaev, Erik, Hagl, Christian, Pichlmaier, Maximilian, Rodloff, Arne Christian, Gräber, Sandra, Kirsch, Katharina, Sandri, Marcus, Kumbhari, Vivek, Behzadi, Armirhossein, Behzadi, Amirali, Correia, Joao Carlos, Mohr, Friedrich Wilhelm, Friedrich, Maik“…CONCLUSION: The high frequency of polymicrobial infections, pathogen diversity, and intracellular persistence of common IE-causing bacteria may provide clues to help explain the persistent and devastating mortality rate observed for IE. …”
Publicado 2017
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8567por Zhang, Shishuo, Wang, Ruifang, Su, Huijuan, Wang, Biaoxiong, Sizhu, Suolang, Lei, Zhixin, Jin, Meilin, Chen, Huanchun, Cao, Jiyue, Zhou, Hongbo“…In summary, this work will provide us some important clues for controlling the prevalence of SIV-H1N1/2009 in pig populations.…”
Publicado 2017
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8568por McDonald, J. Tyson, Gao, Xuefeng, Steber, Cole, Lee Breed, Jawon, Pollock, Caitlin, Ma, Lili, Hlatky, Lynn“…Thus, tumor cells surviving irradiation may shift the landscape of population doubling through inflammatory mediators interacting with the host in a way that impacts tumor recurrence and affects the efficacy of subsequent therapies. Clues to more effective therapies may lie in the development and use of pre-clinical models of post-treatment response to target the source of inflammatory mediators that significantly alter cellular dynamics and molecular pathways in the early stages of tumor recurrence.…”
Publicado 2017
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8569por Olmos-Pérez, Lorena, Roura, Álvaro, Pierce, Graham J., Boyer, Stéphane, González, Ángel F.“…Overall, these results provide new clues about dietary preferences of wild cephalopod paralarvae, thus opening up new scenarios for research on trophic ecology and digestive physiology under controlled conditions.…”
Publicado 2017
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8570“…This comparative analyses could provide important clues for the development of new strategies to prevent and treat malaria in humans, however, the number of functionally annotated proteins is still low for all Plasmodium species. …”
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8571por Guyard, Alice, Danel, Claire, Théou-Anton, Nathalie, Debray, Marie-Pierre, Gibault, Laure, Mordant, Pierre, Castier, Yves, Crestani, Bruno, Zalcman, Gérard, Blons, Hélène, Cazes, Aurélie“…CONCLUSIONS: This extensive characterization of lung fibrosis-associated cancers evidenced molecular alterations which could represent either potential therapeutic targets either clues to the pathophysiology of these particular tumors. …”
Publicado 2017
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8572“…The biopsy revealed unmistakable myopathic changes, marked endomysial and perimysial fibrosis of the muscles, and merely mild infiltration of inflammatory cells but no clues regarding the cause of myopathy. On account of persistent back pain and MRI results indicative of ongoing inflammation, she was prescribed glucocorticoid, which she refused to take. …”
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8573por Hiraki, Hideaki, Kagoshima, Hiroshi, Kraus, Christopher, Schiffer, Philipp H., Ueta, Yumiko, Kroiher, Michael, Schierenberg, Einhard, Kohara, Yuji“…CONCLUSIONS: Our high-quality draft genome of D. coronatus reveals the peculiarities of the genome of parthenogenesis and provides some clues to the genetic basis for parthenogenetic reproduction. …”
Publicado 2017
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8574por Rodolico, Vito, Di Carlo, Paola, Gulotta, Gaspare, D'Arpa, Francesco, Salamone, Giuseppe, Cocorullo, Gianfranco, Agrusa, Antonino, Giammanco, Anna, Sergi, Consolato“…It provides rapid information and clues in patients who may harbour impaired defence mechanisms, concurrent chronic conditions and/or cancer.…”
Publicado 2017
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8575por Sun, Xilong, Wei, Qiang, Cheng, Jie, Bian, Yanzhu, Tian, Congna, Hu, Yujing, Li, Huijie“…Taken together, these results demonstrate that Stim1 as well as Ca(2+) entry contributes cisplatin resistance via inhibition of ER stress-mediated apoptosis, and provide important clues to the mechanisms involved in cisplatin resistance for osteosarcoma treatment. …”
Publicado 2017
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8576por Liu, Chaoyang, Xie, Tao, Chen, Chenjie, Luan, Aiping, Long, Jianmei, Li, Chuhao, Ding, Yaqi, He, Yehua“…The comprehensive expression analysis of the pineapple MYB genes, especially the tissue-preferential and stress-responsive genes, could provide valuable clues for further function characterization. CONCLUSIONS: In this work, we systematically identified AcMYB genes by analyzing the pineapple genome sequence using a set of bioinformatics approaches. …”
Publicado 2017
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8577por Toshniwal, Jay, Chawlani, Romesh, Thawrani, Amit, Sharma, Rajesh, Arora, Anil, Kotecha, Hardik L, Goyal, Mohan, Kirnake, Vijendra, Jain, Pankaj, Tyagi, Pankaj, Bansal, Naresh, Sachdeva, Munish, Ranjan, Piyush, Kumar, Mandhir, Sharma, Praveen, Singla, Vikas, Bansal, Rinkesh, Shah, Vineet, Bhalla, Sunita, Kumar, Ashish“…Cecal involvement and fever are important clues to infective cause. On the contrary CD account for only 13% cases as a cause of ileo-cecalulcers. …”
Publicado 2017
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8578por Honorat, Josephe A., Komorowski, Lars, Josephs, Keith A., Fechner, Kai, St Louis, Erik K., Hinson, Shannon R., Lederer, Sabine, Kumar, Neeraj, Gadoth, Avi, Lennon, Vanda A., Pittock, Sean J., McKeon, Andrew“…CONCLUSIONS: IgLON5-IgG is diagnostic of a potentially treatable neurological disorder, where autoimmune clues are otherwise lacking.…”
Publicado 2017
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8579por Roy, Melanie, Pozzi, Adrien C., Gareil, Raphaëlle, Nagati, Melissande, Manzi, Sophie, Nouioui, Imen, Sharikadze, Nino, Jargeat, Patricia, Gryta, Hervé, Moreau, Pierre-Arthur, Fernandez, Maria P., Gardes, Monique“…Our study in the Caucasus brings new clues to understand symbioses biogeography and their survival in Tertiary and ice-age refugia, and reveals that isolated host populations could be of interest for symbiont diversity conservation.…”
Publicado 2017
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8580por Abe, Kazuhiro, Shimokawa, Jun, Naito, Mao, Munson, Keith, Vagin, Olga, Sachs, George, Suzuki, Hiroshi, Tani, Kazutoshi, Fujiyoshi, Yoshinori“…We also found that A335 is likely to be near the bridging nitrogen at the restricted ring structure of the BYK99 inhibitor. These provide clues to elucidate the binding site parameters and mechanism of P-CAB inhibition of gastric acid secretion.…”
Publicado 2017
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