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  1. 8661
    por Gao, Fan, Gu, Qing-Long, Jiang, Zi-Dong
    Publicado 2019
    “…This study aimed to determine the pathogenetic constituents and factors affecting UACS in children of different age groups, and to identify clinical clues for diagnosing UACS and a method for curative effect evaluation. …”
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    Upper airway cough syndrome in 103 children
  2. 8662
    “…Molecular target expression, as determined at primary diagnosis, may not necessarily present rational treatment clues for the clinical care of recurrent GBM. Further studies need to analyze the therapeutic impact of longitudinal heterogeneity in GBM. …”
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    Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors
  3. 8663
    “…CONCLUSION: Circulating Tfh cell subsets and PCs might play an important role in the pathogenesis of GD, which are potential clues for GD patients' interventions.…”
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    Constitutive Changes in Circulating Follicular Helper T Cells and Their Subsets in Patients with Graves' Disease
  4. 8664
    por Shao, Mingrui, Li, Wenya
    Publicado 2019
    “…In addition, the ceRNA regulatory network of lincRNA-miRNA-mRNA and TF regulatory network were constructed, which would elucidate novel molecular mechanisms determining nCRT response of ESCC, thus providing promising clues for clinical therapy.…”
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    Transcriptional factor regulation network and competitive endogenous RNA (ceRNA) network determining response of esophageal squamous cell carcinomas to neoadjuvant chemoradiotherapy
  5. 8665
    “…Our results provide new clues for studying the potential roles of circRNAs in the regulation of wheat root length. …”
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    Identification and characterization of CircRNAs involved in the regulation of wheat root length
  6. 8666
    “…The long axis of fixation ellipse and the long axis of optic disc became less parallel to each other with increasing AL. Our data may provide clues for improvement of fixation evaluation designs of biometric instruments.…”
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    Fixation Characteristics in Highly Myopic Eyes: the Shanghai High Myopia Study
  7. 8667
    “…Together, these results provide new information about the mechanism of Cry1Ca toxicity and clues to potential resistance factors yet to discover.…”
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    Transcriptomic analysis of Spodoptera frugiperda Sf9 cells resistant to Bacillus thuringiensis Cry1Ca toxin reveals that extracellular Ca(2+), Mg(2+) and production of cAMP are involved in toxicity
  8. 8668
    “…Our study might expand our knowledge on tumorogenesis of NHL and thus provides clues for novel treatment strategies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-019-5718-x) contains supplementary material, which is available to authorized users.…”
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    Both chronic HBV infection and naturally acquired HBV immunity confer increased risks of B-cell non-Hodgkin lymphoma
  9. 8669
    Publicado 2019
    “…From the perspective of circRNA, this study will provide new clues for the pathogenesis, development and prognosis of lung adenocarcinoma, and provide new target for clinical treatment.…”
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    环状RNA分子circ_0007766通过上调细胞周期相关蛋白Cyclin D1/CyclinE1/CDK4的表达促进肺腺癌细胞增殖
  10. 8670
    “…Promoter analysis provided few clues as to the regulation or these genes; however, genes that were down-regulated specifically in the winter biotype Joelle were enriched with the sequence TGGCCCTCGCTCAC, which is over-represented among genes associated with chloroplasts in Arabidopsis. …”
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    Genes associated with chloroplasts and hormone-signaling, and transcription factors other than CBFs are associated with differential survival after low temperature treatments of Camelina sativa biotypes
  11. 8671
    “…Bioinformatics and interaction analyses can provide novel clues for further research into hUMSC treatment of ischemic cerebral infarction.…”
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    Identification of microRNAs and messenger RNAs involved in human umbilical cord mesenchymal stem cell treatment of ischemic cerebral infarction using integrated bioinformatics analysis
  12. 8672
    “…METHODS: We performed gene sequencing, immune cell studies, HLA typing, and analyses of circulating cytotoxic CD4+ T lymphocytes and plasmablasts to seek clues to pathogenesis. DNA from a separate cohort of 99 patients with known IgG4‐RD was also sequenced for the presence of genetic variants in a specific gene, FGFBP2. …”
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    IgG4‐related disease: Association with a rare gene variant expressed in cytotoxic T cells
  13. 8673
    “…CONCLUSION: The results of the present study provide valuable information for better understanding the molecular mechanism underlying drought tolerance of sesame, and also provide useful clues for the genetic improvement of drought tolerance in sesame. …”
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    Transcriptomic and metabolomic profiling of drought-tolerant and susceptible sesame genotypes in response to drought stress
  14. 8674
    “…These findings provide a basis for further investigation of the functions of C2H2-ZF protein genes in the silkworm, and the results offer clues for further research into the development of metamorphosis and female reproduction in the silkworm.…”
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    Genome-wide identification and expression profiling of the C2H2-type zinc finger protein genes in the silkworm Bombyx mori
  15. 8675
    “…The protein-protein interaction networks of ZjbHLHs provide valuable clues toward further studies of their biological functions. …”
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    Genome-wide analysis of the bHLH gene family in Chinese jujube (Ziziphus jujuba Mill.) and wild jujube
  16. 8676
    “…Such studies would be helpful to better comprehend prevailing TB epidemic in context of its historical spread and evolutionary features, and provide clues to better treatment and patient-care in countries and regions concerned by these lineages.…”
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    Two tales: Worldwide distribution of Central Asian (CAS) versus ancestral East-African Indian (EAI) lineages of Mycobacterium tuberculosis underlines a remarkable cleavage for phylogeographical, epidemiological and demographical characteristics
  17. 8677
    “…The nomogram demonstrated good discriminative capacity and satisfactory agreement, which would offer valuable clues for clinicians to distinguish the high-risk NPN population and maintain close surveillance.…”
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    The development of a nomogram to predict post-radiation necrosis in nasopharyngeal carcinoma patients: a large-scale cohort study
  18. 8678
    “…This information can provide clues for interpreting the co-occurrence of phenotypes in a patient. …”
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    Online Artículo Texto
    PhenPath: a tool for characterizing biological functions underlying different phenotypes
  19. 8679
    “…The “targeted and nontargeted proteomic profiling”, metabolomics, matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) imaging, gene expression, and in silico analysis provided clues about its action on Helicoverpa armigera. Fourth instar H. armigera larvae fed on AzaA-based diet (AzaD) suffered from significant mortality, growth retardation, reduced larval mass, complications in molting, and prolonged development. …”
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    Azadirachtin-A from Azadirachta indica Impacts Multiple Biological Targets in Cotton Bollworm Helicoverpa armigera
  20. 8680
    “…The aim of this study was to comprehensively characterise lupus AtMs with a purpose to identify therapeutic clues to target this B cell population in lupus. …”
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    Lupus-associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated
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