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  1. 8701
    “…Transgenic animal models are invaluable research tools for elucidating the pathways and mechanisms involved in the development of neurodegenerative diseases. Mechanistic clues can be revealed by applying labelling techniques such as immunohistochemistry or in situ hybridisation to brain tissue sections. …”
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    QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain
  2. 8702
    “…Research on the feeding behavior of mosquitoes can provide clues to the hosts and vectors involved in disease transmission. …”
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    Assessing the blood meal hosts of Culex quinquefasciatus and Aedes taeniorhynchus in Isla Santa Cruz, Galápagos
  3. 8703
    “…We therefore aimed to provide these quantities indirectly, to obtain epidemiologically interpretable measures of the dynamics of IM occurrence to provide etiological clues. METHODS AND FINDINGS: We used joint modeling of EBV prevalence and IM occurrence data to provide detailed sex- and age-specific EBV infection rates and IM attack rates and derivatives thereof for a target population of all Danes age 0–29 years in 2006–2011. …”
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    Primary Epstein-Barr virus infection with and without infectious mononucleosis
  4. 8704
    “…Finally, we also identified 530 lncRNAs in our datasets, and among them, three lncRNAs targeted the genes related to anthocyanin biosynthesis via cis-regulation, which provided clues for understanding the underlying mechanism of anthocyanin production in fungi. …”
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    Identification of a novel anthocyanin synthesis pathway in the fungus Aspergillus sydowii H-1
  5. 8705
    “…Although, the small sample size warrants further replications, these findings suggest shared genetic architecture between PD symptoms and subcortical structures, and provide interesting clues on PD genetic and neuroimaging features.…”
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    Whole Exome Sequencing Study of Parkinson Disease and Related Endophenotypes in the Italian Population
  6. 8706
    “…Co-expression analyses showed a high correlation along the different spermatogenic stage transitions between the expression patterns of AS lncRNAs and their overlapping protein-coding genes, raising possible clues about lncRNA-related regulatory mechanisms. …”
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    Revealing stage-specific expression patterns of long noncoding RNAs along mouse spermatogenesis
  7. 8707
    “…BACKGROUND: Y‐chromosomal genetic marker haplotypes of individuals can define the paternal kinship or genealogies to which they belong and further provide clues for forensic individual identifications. Studying the genetic structure of the Mongolian group will help to bring to light the Mongolian ethnic origin, and explicate the genetic affinities among the studied and compared populations. …”
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    Forensic characteristics and genetic affinity analyses of Xinjiang Mongolian group using a novel six fluorescent dye‐labeled typing system including 41 Y‐STRs and 3 Y‐InDels
  8. 8708
    “…This study provided some evolutional and physiological clues for the formation of herbivory in grass carp.…”
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    Expansion of sweet taste receptor genes in grass carp (Ctenopharyngodon idellus) coincided with vegetarian adaptation
  9. 8709
    “…CONCLUSION: Prompt carefully assessment of the newborn with ACC in order to exclude concomitant other congenital malformations, provides clues to the underlying pathophysiology, and to the short-term prognosis. …”
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    Recognizable neonatal clinical features of aplasia cutis congenita
  10. 8710
    “…Associating this with gene expression may provide some important clues for a deeper study of posttranscriptional cellular regulation and biomarker research in CRC. …”
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    Post-Transcriptional Dysregulation of microRNA and Alternative Polyadenylation in Colorectal Cancer
  11. 8711
    “…Conclusion: EMT-related induction factors, transcriptional regulators and signaling pathways genes are important players in the malignant progression of glioma and may help in decision making regarding the choice of prognosis assessment and provide us clues to understand EMT epigenetic modification in glioma.…”
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    Genomics and Prognosis Analysis of Epithelial-Mesenchymal Transition in Glioma
  12. 8712
    “…The identification of the bacterial-like FAM46B, as a pluripotent stem cell-specific PAP involved in the maintenance of translational efficiency, provides important clues for further functional studies of this PAP in the early embryonic development of high eukaryotes.…”
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    FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells
  13. 8713
    “…BACKGROUND: Since their emergence in Indonesia in 2005, 200 human infections with clade 2.1 highly pathogenic avian influenza A/H5N1 virus have been reported, associated with exceptionally high mortality (84%) compared to regions affected by other genetic clades of this virus. To provide potential clues towards understanding this high mortality, detailed clinical virological analyses were performed in specimens from 180 H5N1 patients, representing 90% of all Indonesian patients and 20% of reported H5N1-infected patients globally. …”
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    Viral Factors Associated With the High Mortality Related to Human Infections With Clade 2.1 Influenza A/H5N1 Virus in Indonesia
  14. 8714
    “…Our results not only provide risk biomarkers for POD, but also give clues for further investigations into the pathological mechanisms of delirium. …”
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    Proteomic Analysis of Preoperative CSF Reveals Risk Biomarkers of Postoperative Delirium
  15. 8715
    “…CONCLUSION: Our findings provide clues as to the physiological response to magnetosomes and also reveal the corona composition of this membrane-coated nanomaterial after exposure to blood plasma.…”
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    A Protein Corona Adsorbed to a Bacterial Magnetosome Affects Its Cellular Uptake
  16. 8716
    “…The urine proteome may provide important clues to indicate the development of HSPN. METHODS: Here, we detected and compared the urine proteome of patients with HSPN and healthy controls by liquid chromatography-tandem mass spectrometry (LC–MS/MS) in the data-independent acquisition (DIA) mode. …”
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    Urinary proteomics of Henoch-Schönlein purpura nephritis in children using liquid chromatography-tandem mass spectrometry
  17. 8717
    “…We have therefore for the first time confirmed a positive association between rs2544390 and gout with only a Japanese male population. Our study provides clues to a better understanding of the pathogenesis of gout and has the potential to lead to novel therapeutic strategies against gout using LRP2 as a molecular target.…”
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    A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population
  18. 8718
    “…This study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection. …”
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    Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
  19. 8719
    “…Identifying small molecule-miRNA associations (SMiRs) plays an important role in finding new clues for various human disease therapy. Wet experiments can discover credible SMiR associations; however, this is a costly and time-consuming process. …”
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    Identifying Small Molecule-miRNA Associations Based on Credible Negative Sample Selection and Random Walk
  20. 8720
    “…Diagnostic bronchoscopy was negative for bacterial and fungal pathogens. The only clues to the cause of his severe CAP was the presence of relative lymphopenia, atypical lymphocytosis and elevated serum transaminases. …”
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    Severe cytomegalovirus (CMV) community-acquired pneumonia (CAP) in a nonimmunocompromised host
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