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  1. 9201
    “…CONCLUSIONS: This study highlights the importance of p.Gly56Arg in the NR2E3 gene as a common mutation associated with adRP, and provides new clues to its phenotype, which can allow for a better clinical management and genetic counselling of patients and their families.…”
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    Dominant Retinitis Pigmentosa, p.Gly56Arg Mutation in NR2E3: Phenotype in a Large Cohort of 24 Cases
  2. 9202
    “…CONCLUSION: The vitamin D receptor gene TaqI allele polymorphism might be associated with a PCa risk, especially in Asians, which might provide new clues for the pathogenesis research and clinical diagnosis of PCa in the future.…”
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    Online Artículo Texto
    Polymorphisms of vitamin D receptor gene TaqI susceptibility of prostate cancer: a meta-analysis
  3. 9203
    “…The aims of this study were: to establish clinical clues potentially associated with pathogenic CNVs and to identify cytogenetic indicators to predict the pathogenicity of the variants of uncertain significance (VOUS) in a large cohort of paediatric patients. …”
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    Online Artículo Texto
    New insights in the interpretation of array-CGH: autism spectrum disorder and positive family history for intellectual disability predict the detection of pathogenic variants
  4. 9204
    “…Conclusion: Patterns seen in these selected immunoglobulins may provide clues to mechanisms of early abnormalities in neurodevelopment contributing to ASD. …”
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    Online Artículo Texto
    Prenatal and Newborn Immunoglobulin Levels from Mother-Child Pairs and Risk of Autism Spectrum Disorders
  5. 9205
    “…The comparative analysis of differential response of salt sensitive and salt tolerant lines is a judicious approach to obtain essential clues towards understanding the acquisition of salinity tolerance in rice plants. …”
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    Online Artículo Texto
    Interdependency of Reactive Oxygen Species generating and scavenging system in salt sensitive and salt tolerant cultivars of rice
  6. 9206
    por Tosti, Elisabetta, Ménézo, Yves
    Publicado 2016
    “…BACKGROUND: The first clues to the process of gamete activation date back to nearly 60 years ago. …”
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    Online Artículo Texto
    Gamete activation: basic knowledge and clinical applications
  7. 9207
    por Andlauer, Till F. M., Buck, Dorothea, Antony, Gisela, Bayas, Antonios, Bechmann, Lukas, Berthele, Achim, Chan, Andrew, Gasperi, Christiane, Gold, Ralf, Graetz, Christiane, Haas, Jürgen, Hecker, Michael, Infante-Duarte, Carmen, Knop, Matthias, Kümpfel, Tania, Limmroth, Volker, Linker, Ralf A., Loleit, Verena, Luessi, Felix, Meuth, Sven G., Mühlau, Mark, Nischwitz, Sandra, Paul, Friedemann, Pütz, Michael, Ruck, Tobias, Salmen, Anke, Stangel, Martin, Stellmann, Jan-Patrick, Stürner, Klarissa H., Tackenberg, Björn, Then Bergh, Florian, Tumani, Hayrettin, Warnke, Clemens, Weber, Frank, Wiendl, Heinz, Wildemann, Brigitte, Zettl, Uwe K., Ziemann, Ulf, Zipp, Frauke, Arloth, Janine, Weber, Peter, Radivojkov-Blagojevic, Milena, Scheinhardt, Markus O., Dankowski, Theresa, Bettecken, Thomas, Lichtner, Peter, Czamara, Darina, Carrillo-Roa, Tania, Binder, Elisabeth B., Berger, Klaus, Bertram, Lars, Franke, Andre, Gieger, Christian, Herms, Stefan, Homuth, Georg, Ising, Marcus, Jöckel, Karl-Heinz, Kacprowski, Tim, Kloiber, Stefan, Laudes, Matthias, Lieb, Wolfgang, Lill, Christina M., Lucae, Susanne, Meitinger, Thomas, Moebus, Susanne, Müller-Nurasyid, Martina, Nöthen, Markus M., Petersmann, Astrid, Rawal, Rajesh, Schminke, Ulf, Strauch, Konstantin, Völzke, Henry, Waldenberger, Melanie, Wellmann, Jürgen, Porcu, Eleonora, Mulas, Antonella, Pitzalis, Maristella, Sidore, Carlo, Zara, Ilenia, Cucca, Francesco, Zoledziewska, Magdalena, Ziegler, Andreas, Hemmer, Bernhard, Müller-Myhsok, Bertram
    Publicado 2016
    “…Our GWAS approach in a defined population with limited genetic substructure detected associations not found in larger, more heterogeneous cohorts, thus providing new clues regarding MS pathogenesis.…”
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    Online Artículo Texto
    Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation
  8. 9208
    “…In addition, the kinematic graphs of median nerve developed in the present study provide new clues for further studies on the pathophysiology of CTS, and alerting smartphone users to establish proper postural habits when using handheld electronic devices.…”
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    Online Artículo Texto
    Development of Kinematic Graphs of Median Nerve during Active Finger Motion: Implications of Smartphone Use
  9. 9209
    “…Our results furthermore provide important clues to the catalytic mechanism and support the notion of inter-domain cross talk. …”
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    Online Artículo Texto
    Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD
  10. 9210
    “…Knowledge of these multiple gene mutation patterns may give clues in exploring interesting accompanying co-occurrence relationship or mutually exclusive relationship between mutated genes, as well as in predicting benefit of all-wild-type patients from anti-EGFR treatment.…”
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    Mutation profiling in chinese patients with metastatic colorectal cancer and its correlation with clinicopathological features and anti-EGFR treatment response
  11. 9211
    “…Overall, our results provide useful information or clues for our understanding of the functional diversity of legume cystatin family proteins in soybean nodulation and nodule development and for finding nodule-specific cysteine proteases in soybean.…”
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    Search for Nodulation and Nodule Development-Related Cystatin Genes in the Genome of Soybean (Glycine max)
  12. 9212
    “…CONCLUSION: This is the first study to report the interaction between the PNPLA3 rs738409 polymorphism and physical activity or sedentary behavior on NAFLD, providing new clues on the function of the PNPLA3 gene, which will also be useful for future risk assessment and personalized treatment of NAFLD. …”
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    Physical activity and sedentary behavior can modulate the effect of the PNPLA3 variant on childhood NAFLD: a case-control study in a Chinese population
  13. 9213
    “…Our study shows the main adaptive pathway of C. tagal in saline environments, under short-term and long-term treatments of salt stress. This provides vital clues as to which genes may be candidates for breeding salt-tolerant crops and clarifying molecular mechanisms of salt tolerance in C. tagal. …”
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    Online Artículo Texto
    Transcriptome Analysis of Ceriops tagal in Saline Environments Using RNA-Sequencing
  14. 9214
    “…Comparisons of these newly determined M1 and μ2 sequences with newly determined M1 and μ2 sequences from nine additional field isolates and a variety of laboratory T3D clones identified conserved features and/or regions that provide clues about μ2 structure and function. CONCLUSIONS: The findings suggest a model for the domain organization of μ2 and provide further evidence for a role of μ2 in viral RNA synthesis. …”
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    Comparisons of the M1 genome segments and encoded μ2 proteins of different reovirus isolates
  15. 9215
    “…CONCLUSIONS: Our summary provides a comprehensive and conveniently structured basis for grounded thinking about the intermediary social determinants of health within segregated Roma communities in Slovakia and beyond. It offers novel clues regarding how certain determinants might vary therein; how they might be contributing to health-deterioration; and how they might be causally inter-linked here. …”
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    Online Artículo Texto
    Health-endangering everyday settings and practices in a rural segregated Roma settlement in Slovakia: A descriptive summary from an exploratory longitudinal case study
  16. 9216
    “…Further, the expression patterns of the five newly identified MIR166s and 12 target genes were examined during seed development and in response to abiotic stresses, which provided important clues for dissecting their functions and isoform specificity. …”
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    Online Artículo Texto
    Conservation and diversification of the miR166 family in soybean and potential roles of newly identified miR166s
  17. 9217
    “…These findings could provide important clues towards further understanding of fish skeletal system and the roles of proteins playing in regulating diverse biological processes in fish. …”
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    Online Artículo Texto
    Comparative proteomics analysis of teleost intermuscular bones and ribs provides insight into their development
  18. 9218
    “…This study provides new clues into the mechanisms underlying pain deficits associated with SIB and deserves further study in patients with ASD.…”
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    Online Artículo Texto
    A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity
  19. 9219
    “…The results not only show the drug-resistance determinants of FGFR1 gatekeeper mutation but also provide valuable implications and provide vital clues for the development of new inhibitors to combat drug resistance.…”
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    Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study
  20. 9220
    “…CONCLUSIONS: The roles of DEMs like hsa-mir-221 in HCC through interactions with DEGs such as ESR1 and CXCL12 may provide new clues for the diagnosis and treatment of HCC patients. …”
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    Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis
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