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  1. 9421
    “…CONCLUSIONS: Our study reveals a novel BR signaling component OsAK3 in the regulation of grain length, and provides novel clues for uncovering the potential functions of OsAK3 in rice growth and development. …”
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    An Adenylate Kinase OsAK3 Involves Brassinosteroid Signaling and Grain Length in Rice (Oryza sativa L.)
  2. 9422
    “…This study aimed to explore the application value and gender difference of ferroptosis in prognosis and immune prediction to provide clues for targeted therapy of gastric cancer. Methods: We comprehensively evaluated the ferroptosis levels of 1,404 gastric cancer samples from six independent GC cohorts based on ferroptosis-related specific genes and systematically correlated ferroptosis with immune cell infiltrating and gender characteristics. …”
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    Characterization of Two Ferroptosis Subtypes With Distinct Immune Infiltration and Gender Difference in Gastric Cancer
  3. 9423
    “…This study provided important clues for finding new therapeutic targets for sepsis.…”
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    lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients
  4. 9424
    “…CONCLUSIONS: The results indicate that each social group can create its means of using the organoleptic characteristics as clues to select new species as medicinal. Furthermore, this study corroborates the main prediction of the Utilitarian Equivalence Model, that people in different environments choose plants with traits in common for the same functions.…”
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    Taste and chemical composition as drives for utilitarian redundancy and equivalence: a case study in local medical systems in Northeastern Brazil
  5. 9425
    “…Furthermore, experimental results showed that MAL2 deletion negatively regulated the proliferation, migration, invasion, and EMT of OC, indicating that MAL2 is a novel oncogene that can activate EMT, significantly promote both the proliferation and migration of OC in vitro and in vivo, and provide new clues for treatment strategies.…”
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    Multi-Omics Analysis of the Therapeutic Value of MAL2 Based on Data Mining in Human Cancers
  6. 9426
    “…In such a situation, a systematic analysis on these genes could provide clues to understand the molecular features of two disorders and their comorbidity. …”
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    A Systematic Analysis on the Genes and Their Interaction Underlying the Comorbidity of Alzheimer's Disease and Major Depressive Disorder
  7. 9427
    “…Meanwhile, MRI and BAEP can also provide early abnormal information for the judgment of central nervous system damage of the children with NHB who have no acute bilirubin encephalopathy (ABE) clinical features, and provide clues for early treatment and early intervention.…”
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    Analysis on the MRI and BAEP Results of Neonatal Brain With Different Levels of Bilirubin
  8. 9428
    “…The findings would not only have repercussions on efforts to precisely evaluate the burden of IHD attributable to PM(2.5), but would also provide novel clues for cardiovascular risk prevention accounting for sex-based differences.…”
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    Sex Differences in Cardiovascular Risk Associated With Long-Term PM(2.5) Exposure: A Systematic Review and Meta-Analysis of Cohort Studies
  9. 9429
    “…We propose that the use of circRNAs to obtain additional clues for forensic investigations and serve as aging indicators for age prediction would become a promising field of interest.…”
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    Circular RNA as a Potential Biomarker for Forensic Age Prediction
  10. 9430
    “…This study aims to analyze the prognostic value of RBM15, and to demonstrate the correlation between RBM15 expression and tumor immunity, as well as to provide clues for further mechanism research. The results showed that RBM15 was mutated or copy number varied in 25 types of cancer. …”
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    N6-Methyladenosine Methylation Regulator RBM15 is a Potential Prognostic Biomarker and Promotes Cell Proliferation in Pancreatic Adenocarcinoma
  11. 9431
    “…Overall, our studies suggested a previously unrecognized role of SAPCD2 in the E2F signaling pathway and a potential therapeutic approach for NB, as well as clues for understanding the differences in subcellular distribution of E2F1 and E2F7 during their nucleocytoplasmic shuttling.…”
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    SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7
  12. 9432
    “…We believe that our obtained chimeric protein resulted from the fusion of GvpA and CsgA proteins with DOPA-containing Mfp proteins, expressed in the methylotrophic yeast, P. pastoris, not only presents a candidate for future biomedical applications but also provides novel biological clues used for high-performance bioinspired biomaterial designation. …”
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    A novel recombinant chimeric bio-adhesive protein consisting of mussel foot protein 3, 5, gas vesicle protein A, and CsgA curli protein expressed in Pichia pastoris
  13. 9433
    “…MS cases in the context of genetic diseases may provide different approaches and clues towards identifying novel genes and pathways involved in MS pathogenesis. …”
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    Familial multiple sclerosis in patients with Von Hippel-Lindau disease
  14. 9434
    “…These results may provide clues for new potential targets for anti-virulence adjuvant therapy on S. aureus infection.…”
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    Insights Into the Impact of Small RNA SprC on the Metabolism and Virulence of Staphylococcus aureus
  15. 9435
    “…CONCLUSIONS: In conclusion, the present study provides evidence of a causal association between diabetes and increased risk of AD, and also useful genetic clues for drug development.…”
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    Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease
  16. 9436
    “…These new findings present clues for effective and functional manipulation of human IDD-related bioremediation and healthcare.…”
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    Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc Degeneration
  17. 9437
    “…Moreover, the differentially abundant miRNA cargo in host EVs associated with S. japonicum infection may also provide valuable clues for identifying novel biomarkers for schistosomiasis diagnosis.…”
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    Characterization of MicroRNA Cargo of Extracellular Vesicles Isolated From the Plasma of Schistosoma japonicum-Infected Mice
  18. 9438
    “…In summary, this study demonstrates that PPC can ameliorate HFD-induced liver steatosis via reprogramming metabolic and inflammatory processes, which inspire clues for further clarifying the intervention mechanism of PPC against NAFLD.…”
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    Polyene Phosphatidylcholine Ameliorates High Fat Diet-Induced Non-alcoholic Fatty Liver Disease via Remodeling Metabolism and Inflammation
  19. 9439
    “…Patterns of genetic overlap between these phenotypes provide clues to uncovering the mechanisms underlying familial co-aggregation.…”
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    Familial co-aggregation and shared heritability between depression, anxiety, obesity and substance use
  20. 9440
    “…In conclusion, our results revealed the molecular basis of LGG, provided valuable clues for our understanding of m5C-related lncRNAs, and filled a gap between epigenetics and tumor microenvironment.…”
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    5-Methylcytosine Related LncRNAs Reveal Immune Characteristics, Predict Prognosis and Oncology Treatment Outcome in Lower-Grade Gliomas
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