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  1. 9561
    “…CONCLUSION: The present meta-analysis confirmed that SC-EV therapy could improve neuron function and reduce infarct volume in a preclinical rodent ischemic stroke model, providing helpful clues for human clinical trials on SC-EVs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13287-023-03270-2.…”
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    Therapeutic potential of stem cell extracellular vesicles for ischemic stroke in preclinical rodent models: a meta-analysis
  2. 9562
    “…These findings deepen our understanding of regulatory mechanisms involved in the production of polyether ionophores and provide novel clues for the rational design of industrial strains for scaled-up production.…”
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    Comparative and Functional Analyses Reveal Conserved and Variable Regulatory Systems That Control Lasalocid Biosynthesis in Different Streptomyces Species
  3. 9563
    “…In addition, the effectiveness of EVs in treating sepsis must be studied in large animal studies to provide important clues for human clinical trials. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-023-04121-7.…”
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    Protective properties of extracellular vesicles in sepsis models: a systematic review and meta-analysis of preclinical studies
  4. 9564
    “…Phospho-proteome studies provided further clues that decreased phosphorylation of proteins that constitute the Toxoplasma cytoskeleton could be responsible for altered morphology in TgTKL4-deficient parasites. …”
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    TgTKL4 Is a Novel Kinase That Plays an Important Role in Toxoplasma Morphology and Fitness
  5. 9565
    “…Single-cell transcriptome analysis provided valuable clues for further screening of pancreatic endocrine cells and differentiation of pancreatic islet cells. …”
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    Single-cell transcriptome analysis of NEUROG3+ cells during pancreatic endocrine differentiation with small molecules
  6. 9566
    “…There were no significant changes in muscle and bone characteristics except for single clues (femur diameter, bone resorption marker CTX-1). …”
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    Effects of more natural housing conditions on the muscular and skeletal characteristics of female C57BL/6J mice
  7. 9567
    por Fu, Weili, Yang, Runze, Li, Jian
    Publicado 2023
    “…Our results provide new insights into the control of tendinopathy and potential clues to developing novel diagnostic and therapeutic strategies. …”
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    Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathy
  8. 9568
    “…This risk model may serve as a prognostic signature and provide clues for individualized immunotherapy for HNSCC patients.…”
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    Necrotic related-lncRNAs: Prediction of prognosis and differentiation between cold and hot tumors in head and neck squamous cell carcinoma
  9. 9569
    por Shen, Fangfang, Guo, Wei, Song, Xia, Wang, Bei
    Publicado 2023
    “…We also identified new prognostic biomarkers, which could provide potential clues for targeted therapies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13000-023-01349-1.…”
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    Molecular profiling and prognostic biomarkers in chinese non-small cell lung cancer cohort
  10. 9570
    “…Genetic syndromes often show facial features that provide clues for the diagnosis. However, memorizing these features is a challenging task for clinicians. …”
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    Computer-aided facial analysis as a tool to identify patients with Silver–Russell syndrome and Prader–Willi syndrome
  11. 9571
    “…AIM: To explore the relationship between intestinal microbiota and DR among patients in the southeast coast of China, and provide clues for novel ways to prevention and treatment methods of DR. …”
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    Alteration of intestinal microbiota is associated with diabetic retinopathy and its severity: Samples collected from southeast coast Chinese
  12. 9572
    “…Our study shows that determining taxon-specific cell division rates complements omics-based tools and provides unprecedented clues on individual bacterial growth strategies including bottom–up and top–down controls. …”
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    In situ cell division and mortality rates of SAR11, SAR86, Bacteroidetes, and Aurantivirga during phytoplankton blooms reveal differences in population controls
  13. 9573
    “…Studies diving deeper into household dynamics might give us some clues on intra-household behaviors and roles that could be influencing how food access relates to dietary quality.…”
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    Food access, domestic environments, and dietary quality of low-middle income Chilean children during the COVID-19 pandemic
  14. 9574
    “…In addition, in silico characterization of existing and new drugs might offer clues for future investigations and aid in the development of anticancer treatments. …”
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    Exploration of potential molecular mechanisms and genotoxicity of anti-cancer drugs using next generation knowledge discovery methods
  15. 9575
    “…CONCLUSIONS: The results indicated that referral to colposcopy is recommended in managing women with HR-HPV positive, and colposcopic impressions provide key clues for identification CIN2+.…”
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    Detection of cervical high-grade squamous intraepithelial lesions and assessing diagnostic performance of colposcopy among women with oncogenic HPV
  16. 9576
    “…Additionally, we sought to identify the morphometric measurements which might be related to patients' clinical characteristics, thus providing more clues of specific brain regions involved in the mechanism of idiopathic dystonia. …”
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    Cortical and Subcortical Structural Abnormalities in Patients With Idiopathic Cervical and Generalized Dystonia
  17. 9577
    “…CONCLUSIONS: FHB exerts anti-inflammatory and melanogenesis-promoting effects via the effect of multi-component on multi-target, among which the JAK-STAT pathway is a validated FHB-vitiligo target, providing new ideas and clues for the development of vitiligo therapy.…”
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    Combining network pharmacology, molecular docking, molecular dynamics simulation, and experimental verification to examine the efficacy and immunoregulation mechanism of FHB granules on vitiligo
  18. 9578
    “…This study provides new clues about haloarchaeal amino acid metabolism and confirms the convenience and efficiency of endogenous CRISPR-Cas system-based genome editing in haloarchaea.…”
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    Dissecting the Arginine and Lysine Biosynthetic Pathways and Their Relationship in Haloarchaeon Natrinema gari J7-2 via Endogenous CRISPR-Cas System-Based Genome Editing
  19. 9579
    “…Together, the results provide clues to an early endocrine influence on lifetime cruciate ligament survival. …”
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    Correlates of estimated lifetime cruciate ligament survival inform potential rupture risk reduction strategies: findings from the Exceptional Aging in Rottweilers Study
  20. 9580
    “…These results provide clues to the mechanism of LZTR1-deficiency carcinogenesis.…”
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    LZTR1 deficiency exerts high metastatic potential by enhancing sensitivity to EMT induction and controlling KLHL12-mediated collagen secretion
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