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  1. 9601
    “…CONCLUSIONS/SIGNIFICANCE: Taken together, S9 targets both PI3K-Akt-mTOR signaling and microtubule cytoskeleton, which combinatorially contributes its antitumor activity and provides new clues for anticancer drug design and development.…”
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    S9, a Novel Anticancer Agent, Exerts Its Anti-Proliferative Activity by Interfering with Both PI3K-Akt-mTOR Signaling and Microtubule Cytoskeleton
  2. 9602
    “…Moreover, it advances the use of echinoderms in regenerative biology, animals that because of their amazing properties and their key evolutionary position, might provide important clues to the genetic basis of regenerative processes.…”
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    Gene expression profiling of intestinal regeneration in the sea cucumber
  3. 9603
    “…Hierarchical clustering of 105 selected contigs provided clues about stress- responsive candidate genes and their expression profile showed predominance in specific stress-challenged libraries. …”
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    A comprehensive resource of drought- and salinity- responsive ESTs for gene discovery and marker development in chickpea (Cicer arietinum L.)
  4. 9604
    “…Fine mapping of aberrations in gene-enriched subtelomeric regions provides essential clues for localizing critical regions, and provides a strategy for identifying new candidate genes. …”
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    Submicroscopic subtelomeric aberrations in Chinese patients with unexplained developmental delay/mental retardation
  5. 9605
    “…While toxicokinetic modeling did not explain mixture interactions, gene expression profiling and further Gene Ontology-based functional genomics analysis provided clues that the decrement of toxicity may arise from the development of specific toxicodynamics. …”
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    Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment
  6. 9606
    “…DISCUSSION: This study may provide clues to the sensorimotor mechanisms that explain observed functional deficits associated with LBP, as well as the mechanism of action of SM. …”
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    Effect of spinal manipulation on sensorimotor functions in back pain patients: study protocol for a randomised controlled trial
  7. 9607
    “…This study shows that a method exploiting the structure of co-expressions among genes can help identify genomic regions involved in trans regulation of sets of genes and can provide clues for understanding the mechanisms linking genome-wide association loci to disease.…”
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    Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans
  8. 9608
    “…We sought to determine if the transcriptomic profiles of fibroblasts derived from DC-affected palmar fascia, adjacent phenotypically normal palmar fascia, and non-DC palmar fascial tissues might provide mechanistic clues to understanding the puzzle of disease predisposition and recurrence in DC. …”
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    Fibroblasts from phenotypically normal palmar fascia exhibit molecular profiles highly similar to fibroblasts from active disease in Dupuytren's Contracture
  9. 9609
    “…These findings provide new clues for further research in both disorders.…”
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    Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis and hypersensitivity pneumonitis
  10. 9610
    “…Genomic regions specific to each strain provide clues to its lifestyle, ecological adaptation, and physiological role in the rhizosphere.…”
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    Comparative genomic analysis of four representative plant growth-promoting rhizobacteria in Pseudomonas
  11. 9611
    “…Taken together, our study implies the important roles of miRNAs in P signaling and provides clues for deciphering the functions for microRNA/target modules in soybean.…”
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    Genome-wide identification of soybean microRNAs and their targets reveals their organ-specificity and responses to phosphate starvation
  12. 9612
    “…Here, we investigated endogenous ASB10 protein expression in human trabecular meshwork (HTM) cells to provide the first clues to the biologic function of this protein. METHODS: Primary HTM cells were cultured and immunostained with anti-ASB10 and various biomarkers of the ubiquitin-mediated proteasomal and autophagy-lysosomal degradation pathways. …”
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    Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells
  13. 9613
    “…Our findings provide new clues for future functional studies of the role of small RNAs in insect development and evolution.…”
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    RIP-seq of BmAgo2-associated small RNAs reveal various types of small non-coding RNAs in the silkworm, Bombyx mori
  14. 9614
    por Kunze, Gotthard, Gaillardin, Claude, Czernicka, Małgorzata, Durrens, Pascal, Martin, Tiphaine, Böer, Erik, Gabaldón, Toni, Cruz, Jose A, Talla, Emmanuel, Marck, Christian, Goffeau, André, Barbe, Valérie, Baret, Philippe, Baronian, Keith, Beier, Sebastian, Bleykasten, Claudine, Bode, Rüdiger, Casaregola, Serge, Despons, Laurence, Fairhead, Cécile, Giersberg, Martin, Gierski, Przemysław Piotr, Hähnel, Urs, Hartmann, Anja, Jankowska, Dagmara, Jubin, Claire, Jung, Paul, Lafontaine, Ingrid, Leh-Louis, Véronique, Lemaire, Marc, Marcet-Houben, Marina, Mascher, Martin, Morel, Guillaume, Richard, Guy-Franck, Riechen, Jan, Sacerdot, Christine, Sarkar, Anasua, Savel, Guilhem, Schacherer, Joseph, Sherman, David J, Stein, Nils, Straub, Marie-Laure, Thierry, Agnès, Trautwein-Schult, Anke, Vacherie, Benoit, Westhof, Eric, Worch, Sebastian, Dujon, Bernard, Souciet, Jean-Luc, Wincker, Patrick, Scholz, Uwe, Neuvéglise, Cécile
    Publicado 2014
    “…Protein components of different pathways for carbon and nitrogen source utilization were identified, which so far has remained unexplored in yeast, offering clues for further biotechnological developments. …”
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    The complete genome of Blastobotrys (Arxula) adeninivorans LS3 - a yeast of biotechnological interest
  15. 9615
    por Li, Xinguo, Yang, Xiaohui, Wu, Harry X
    Publicado 2013
    “…Interestingly, many genes related to hormone and calcium signalling as well as various environmental stresses were exclusively up-regulated in CW, providing important clues for earlier molecular signatures of reaction wood formation under gravity stimulus. …”
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    Transcriptome profiling of radiata pine branches reveals new insights into reaction wood formation with implications in plant gravitropism
  16. 9616
    “…Our findings elucidate the evolutionary status of the BATV NM/12 strain among different orthobunyavirus strains and may provide some clues to prevent the emergence of BATV infection in cattle and humans.…”
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    Isolation and complete nucleotide sequence of a Batai virus strain in Inner Mongolia, China
  17. 9617
    “…CONCLUSION: Taken together, our findings provide the first clues regarding the role of the miR-143/145 cluster as a tumor suppressor in breast cancer through the inhibition of ERBB3 translation. …”
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    miR-143 and miR-145 synergistically regulate ERBB3 to suppress cell proliferation and invasion in breast cancer
  18. 9618
    “…Our overall findings suggest that impairment of TFIIH-mediated function in transcription in placenta is a likely mechanism leading to preeclampsia and provide etiologic clues which may be translated into therapeutic and preventive measures.…”
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    Nucleotide excision repair/transcription gene defects in the fetus and impaired TFIIH-mediated function in transcription in placenta leading to preeclampsia
  19. 9619
    “…Nevertheless, only a limited number of these genes have been functionally characterized, with few clues consequently available for understanding the molecular control of apomixis. …”
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    PnTgs1-like expression during reproductive development supports a role for RNA methyltransferases in the aposporous pathway
  20. 9620
    “…Therefore, our findings provide valuable clues toward the understanding the of mechanisms of NPC pathogenesis and provide an opportunity to develop new effective clinical therapies in the future. …”
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    MiR-124 suppresses tumor growth and metastasis by targeting Foxq1 in nasopharyngeal carcinoma
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