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  1. 9741
    “…Taken together, the recombinant version of HcABHD might have further application under field conditions in protecting goats against H. contortus infection, and the integrated immunological pipeline of ES antigen identification, screening and characterization may provide new clues for further development of recombinant subunit vaccines to control H. contortus.…”
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    Protection studies of an excretory–secretory protein HcABHD against Haemonchus contortus infection
  2. 9742
    “…These results provide clues regarding the molecular basis of the replacement of Chrysanthemum morifolium ray florets with normally developed pistils and purple corollas with mutant ray florets with green corollas and vegetative buds. …”
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    Whole-transcriptome analysis of differentially expressed genes in the mutant and normal capitula of Chrysanthemum morifolium
  3. 9743
    “…These findings may provide timely clues and potential directions for better understanding the molecular pathogenesis of COVID-19 and the genetic basis of heterogeneous susceptibility, with potential impact on new therapeutic options. …”
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    Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data
  4. 9744
    “…This study revealed a landscape of RNAs in the intestine of S. schlegelii during E. tarda infection and provided clues for further study on the immune mechanisms and signaling networks based on the circRNA-miRNA-mRNA axis in S. schlegelii.…”
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    Integrated Analysis of circRNA-miRNA-mRNA Regulatory Networks in the Intestine of Sebastes schlegelii Following Edwardsiella tarda Challenge
  5. 9745
    “…CONCLUSIONS: Our research provides new clues for uncovering the mechanisms of lncRNAs in HD and can be used as the focus for further investigation.…”
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    Integrated analysis of differentially expressed genes and construction of a competing endogenous RNA network in human Huntington neural progenitor cells
  6. 9746
    “…Understanding the multifaceted impacts may provide early clues for clinical intervention prior to actual disease presentation. …”
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    Air pollution exposure is linked with methylation of immunoregulatory genes, altered immune cell profiles, and increased blood pressure in children
  7. 9747
    “…Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection, providing clues for therapeutic potentials in treating COVID-19.…”
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    Dynamic blood single-cell immune responses in patients with COVID-19
  8. 9748
    “…Therefore, these results might suggest clues to reveal the early immune response of the canine to B. canis infection, particularly TLR signaling.…”
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    Identification of Dendritic Cell Maturation, TLR, and TREM1 Signaling Pathways in the Brucella canis Infected Canine Macrophage Cells, DH82, Through Transcriptomic Analysis
  9. 9749
    “…These results reveal the mechanisms underlying anti-PD-1 therapy response and offer abundant clues for potential strategies to improve immunotherapy.…”
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    Investigating Mechanisms of Response or Resistance to Immune Checkpoint Inhibitors by Analyzing Cell-Cell Communications in Tumors Before and After Programmed Cell Death-1 (PD-1) Targeted Therapy: An Integrative Analysis Using Single-cell RNA and Bulk-RNA Sequencing Data
  10. 9750
    “…AIM OF REVIEW: We present a mini review about VOCs produced by microorganisms and Malassezia species, and hypothesize about their role in its metabolism, which would reveal clues about host-pathogen interaction. KEY SCIENTIFIC CONCEPTS OF REVIEW: Since living organisms inhabit a similar environment, the interaction processes occur naturally; as a result, a signal and a response from participants of these processes become important in understanding several biological behaviors. …”
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    Learning about microbial language: possible interactions mediated by microbial volatile organic compounds (VOCs) and relevance to understanding Malassezia spp. metabolism
  11. 9751
    “…CONCLUSIONS: As a ceRNA, lncRNA ZEB1-AS1 may play a vital role in inhibiting HCC progression through miR-23c, which will provide new clues and theoretical basis for the HCC diagnosis and treatment.…”
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    LncRNA ZEB1-AS1 regulates hepatocellular carcinoma progression by targeting miR-23c
  12. 9752
    “…The analysis of the expression profiles of diverse tissues under Na(2)SO(4) stress and identification of relevant key hub genes in a network crosstalk will provide a strong foundation and valuable clues for genetic improvements of cotton in response to various salt stresses.…”
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    Transcriptome analysis of upland cotton revealed novel pathways to scavenge reactive oxygen species (ROS) responding to Na(2)SO(4) tolerance
  13. 9753
    “…Predictors may differ for different interventions, suggesting clues to personalize and optimize rehabilitation. …”
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    Predictors of Function, Activity, and Participation of Stroke Patients Undergoing Intensive Rehabilitation: A Multicenter Prospective Observational Study Protocol
  14. 9754
    “…CONCLUSION: These findings may provide new clues for exploring the molecular mechanisms and targeted therapy in OSCC. …”
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    Prognostic biomarkers and therapeutic targets in oral squamous cell carcinoma: a study based on cross-database analysis
  15. 9755
    “…CONCLUSION: To some extent, this survey reflects the shortage of medical talent in China and provides possible clues for solving this problem. In addition, these findings may provide a perspective for understanding the development of health services in developing countries. …”
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    An investigation of the intention and reasons of senior high school students in China to choose medical school
  16. 9756
    “…OBJECTIVE: The aim of the present study was to investigate the protective effects and mechanisms of KLK1 on aging-related prostate alterations and search clues about the application of KLK1 to the treatment of human BPH. …”
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    Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates
  17. 9757
    “…BACKGROUND: We investigated the prognostic effects and their patterns of immune infiltration of hippo pathway core genes in lung squamous cell carcinoma, in order to find some clues for underlying mechanisms of LUSC tumorigenesis and help developing new therapeutic methods. …”
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    Hippo Pathway Core Genes Based Prognostic Signature and Immune Infiltration Patterns in Lung Squamous Cell Carcinoma
  18. 9758
    “…It provides deepening insights into the molecular mechanisms and provides vital clues in seeking novel therapeutic targets for IPAH.…”
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    Essential Genes and MiRNA–mRNA Network Contributing to the Pathogenesis of Idiopathic Pulmonary Arterial Hypertension
  19. 9759
    “…We selected 12400 SARS-CoV-2 tests detected in Wuhan in the first semester of 2020 and made a systematic analysis of them, in order to find some beneficial clue for the consistent prevention and control of COVID-19. …”
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    A retrospective analysis of 12,400 SARS-CoV-2 RNA tests in patients with COVID-19 in Wuhan
  20. 9760
    “…We further used two case studies to demonstrate the detailed functionality of GLEANER and highlighted that it can provide valuable clues to the epigenetic regulation mechanisms in the genetic and epigenetic information transmitted during the germline cycle. …”
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    GLEANER: a web server for GermLine cycle Expression ANalysis and Epigenetic Roadmap visualization
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