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  1. 9821
    por Li, Qian, Zhang, Liyu, Xu, Yuxin
    Publicado 2022
    “…Exploring the mechanism by which oxidative stress and antioxidant stress occur in TM cells will offer clues to aid the development of new treatments. METHODS AND RESULTS: In our study, we cultured TM cells and used H(2)O(2) and SOD to induce and inhibit oxidative stress, respectively. …”
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    Label-free LC–MS/MS proteomics analyses reveal proteomic changes in oxidative stress and the SOD antioxidant strategy in TM cells
  2. 9822
    “…The susceptibility of female fetuses to in utero mother-to-child transmission, especially in the setting of recent maternal infection, is a curiosity that also provides clues to mechanisms by which cure may be achieved, since initial findings are that viral rebound is less frequent among males who interrupt cART. …”
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    Role of Early Life Cytotoxic T Lymphocyte and Natural Killer Cell Immunity in Paediatric HIV Cure/Remission in the Anti-Retroviral Therapy Era
  3. 9823
    “…CONCLUSION: Our study provides a comprehensive landscape of the gut microbiota between OA and KBD patients and provides clues for better understanding the mechanisms underlying the pathogenesis of OA and KBD. …”
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    Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China
  4. 9824
    “…Yet, a better understanding of the inability of parasites to complete their life cycles in less suitable hosts may hold clues for their control. To shed light on the molecular basis of parasite (non-)maturation, we analyzed transcriptomes of thorny-headed worms (Acanthocephala: Pomphorhynchus laevis), and compared developmentally arrested worms excised from European eel (Anguilla anguilla) to developmentally unrestricted worms from barbel (Barbus barbus). …”
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    Host-dependent impairment of parasite development and reproduction in the acanthocephalan model
  5. 9825
    “…DATA EXTRACTION AND SYNTHESIS: Abstracted data included years of publication and study period, country, setting (eg, university vs community hospital), defining criteria and category outcome, structured or nonstructured diagnostic protocol evaluation, sex, temperature threshold and measurement, duration of fever and hospitalization before final diagnoses, and contribution of potential diagnostic clues, biochemical and immunological serologic studies, microbiology cultures, histologic analysis, and imaging studies. …”
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    Prospective Studies Comparing Structured vs Nonstructured Diagnostic Protocol Evaluations Among Patients With Fever of Unknown Origin: A Systematic Review and Meta-analysis
  6. 9826
    “…Likewise, murine single-cell transcriptional atlases of cerebellar development have recently provided further clues into MB subgroup origins, particularly for poorly defined Group 3 and Group 4-MB. …”
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    MEDB-78. Unified rhombic lip origins of Group 3 and Group 4 medulloblastoma
  7. 9827
    “…MAIN TEXT: Recent studies detected several clues of neuroinflammation in PD samples using postmortem human PD brains and various PD animal models. …”
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    The role of Toll-like receptors and neuroinflammation in Parkinson’s disease
  8. 9828
    “…This exploratory evaluation aims at providing clues and concepts for this association to facilitate future larger-scale and longitudinal studies on that aspect. …”
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    Lower limb bone geometry in adult individuals with X-linked hypophosphatemia: an observational study
  9. 9829
    “…Our results also provide clues into species-specific adaptations that enable survival and potential speciation within chemosynthetic ecosystems. …”
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    Genetic diversity and connectivity of chemosynthetic cold seep mussels from the U.S. Atlantic margin
  10. 9830
    “…This study provides cutoff values of MRS to serve as clues in differentiating MSA-C from SCAs.…”
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    Radiological hints for differentiation of cerebellar multiple system atrophy from spinocerebellar ataxia
  11. 9831
    “…These findings may provide clues for future studies to explore early diagnostic imaging markers of cognitive impairment in relation to T2DM.…”
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    Cerebral Small Vessel Disease is Associated with Mild Cognitive Impairment in Type 2 Diabetes Mellitus
  12. 9832
    “…A detailed analysis of subtle historical clues would help promote earlier diagnosis of FD.…”
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    Fabry disease with acute myocardial infarction, left ventricular thrombosis, and pericardial effusion: A case report
  13. 9833
    “…The autostereoscopic dynamic stereopsis assessment device with brighter luminance, lower crosstalk, and higher color restoration degree was more effective than the traditional instrument at displaying dynamic clues for clinical dynamic stereopsis assessment. …”
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    A novel clinical dynamic stereopsis assessment based on autostereoscopic display system
  14. 9834
    “…This work may provide proteomic clues for treating RA by BZXD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12906-022-03663-5.…”
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    Quantitative proteomic analysis of Bi Zhong Xiao decoction against collagen-induced arthritis rats in the early and late stages
  15. 9835
    “…We demonstrate risk factors for incidence and complications to supply clues for future intervention and improve patient prognosis.…”
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    Analysis of Clinical Features and Risk Factors in Pregnant Women With Miliary Pulmonary Tuberculosis After In Vitro Fertilization Embryo Transfer
  16. 9836
    “…Conclusion: Therefore, this study not only confirmed the potential mechanism of CEP in the treatment of COVID-19 at the molecular level, but also found that TNF and IL-17 inhibitors, which are commonly used in the treatment of RA, AS and GA, may also affect the treatment of COVID-19, which provides new clues and theoretical basis for the rapid discovery of effective therapeutic drugs for COVID-19.…”
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    The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19
  17. 9837
    “…We found that hsa-miR-29c-5p was upregulated in an extremely high mammographic density context and potential targets were identified that might provide clues of the relationship between high mammographic density and breast cancer risk. …”
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    Elevated miR-29c-5p Expression in Nipple Aspirate Fluid Is Associated with Extremely High Mammographic Breast Density
  18. 9838
    “…Insights of its cell-specific expression and relevant proinflammatory mechanisms will provide clues for the control of CNS inflammation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13578-022-00867-7.…”
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    D-dopachrome tautomerase drives astroglial inflammation via NF-κB signaling following spinal cord injury
  19. 9839
    “…CONCLUSION: JAKCP exerted regulatory immune functions through multi-component, multi-target and multi-pathway, thereby providing novel ideas and clues for the treatment of AIDS.…”
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    Study on the Mechanism of Improving HIV/AIDS Immune Function with Jian Aikang Concentrated Pill Based on Network Pharmacology Combined with Experimental Validation
  20. 9840
    “…The identified DE miRNAs provided clues on COVID-19 pathogenesis, highlighting signatures of impaired interferon and antiviral responses, inflammation, organ damage and cardiovascular failure as associated with severe disease and death.…”
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    Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients
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